Psychiatry Research: Neuroimaging
Volume 171, Issue 3 , Pages 155-165 , 31 March 2009

Medial prefrontal default-mode hypoactivity affecting trait physical anhedonia in schizophrenia

  • Il Ho Park

      Affiliations

    • Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea
    • ,
  • Jae-Jin Kim

      Affiliations

    • Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea
    • Corresponding Author InformationCorresponding author. Severance Mental Health Hospital, 696-6 Tanbul-dong, Gwangju-si, Gyeonggi-do, South Korea 464-100. Tel.: +82 31 760 9402; fax: +82 31 761 7582.
    • ,
  • Jiwon Chun

      Affiliations

    • Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea
    • ,
  • Young Chul Jung

      Affiliations

    • Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea
    • ,
  • Jeong Ho Seok

      Affiliations

    • Department of Psychiatry, Hallym University Sacred Heart Hospital, Anyang, South Korea
    • ,
  • Hae-Jeong Park

      Affiliations

    • Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul, South Korea
    • ,
  • Jong Doo Lee

      Affiliations

    • Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul, South Korea

Received 11 August 2007 ,Revised 13 February 2008 ,Accepted 30 March 2008.

References 

  1. Andreasen NC. A unitary model of schizophrenia: Bleuler's “fragmented phrene” as schizencephaly. Archives of General Psychiatry. 1999;56:781–787
  2. Andreasen NC, Rezai K, Alliger R, Swayze VW, Flaum M, Kirchner P, et al. Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophreniaAssessment with xenon 133 single-photon emission computed tomography and the Tower of London. Archives of General Psychiatry. 1992;49:943–958
  3. Andreasen NC, Arndt S, Miller D, Flaum M, Nopoulos P. Correlational studies of the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms: an overview and update. Psychopathology. 1995;28:7–17
  4. Andreasen NC, O'Leary DS, Flaum M, Nopoulos P, Watkins GL, Boles PL, et al. Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naive patients. Lancet. 1997;349:1730–1734
  5. Blanchard JJ, Mueser KT, Bellack AS. Anhedonia, positive and negative affect, and social functioning in schizophrenia. Schizophrenia Bulletin. 1998;24:413–424
  6. Buchsbaum MS, Potkin SG, Siegel BV, Lohr J, Katz M, Gottschalk LA, et al. Striatal metabolic rate and clinical responses to neuroleptics in schizophrenia. Archives of General Psychiatry. 1992;49:966–974
  7. Carpenter WT, Heinrichs MD, Wagman A. Deficit and nondeficit forms of schizophrenia: the concept. American Journal of Psychiatry. 1988;145:578–583
  8. Chapman LJ, Chapman JP, Raulin ML. Scale for physical and social anhedonia. Journal of Abnormal Psychology. 1976;85:374–382
  9. Crespo-Facorro B, Paradiso S, Andreasen NC, O'Leary DS, Watkins GL, Ponto LLB, et al. Neural mechanisms of anhedonia in schizophrenia: a PET study of response to unpleasant and pleasant odors. JAMA. 2001;286:427–435
  10. D'Argembeau A, Collette F, Van der Linden M, Laureys S, Del Fiore G, Degueldre C, et al. Self-referential reflective activity and its relationship with rest: a PET study. Neuroimage. 2005;25:616–624
  11. Davis CE, Jeste DV, Eyler LT. Review of longitudinal functional neuroimaging studies of drug treatments in patients with schizophrenia. Schizophrenia Research. 2005;78:45–60
  12. Dollfus S, Everitt B, Ribeyre JM, Assouly-Besse F, Sharp C, Petit M. Identifying subtypes of schizophrenia by cluster analyses. Schizophrenia Bulletin. 1996;22:545–555
  13. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders. New York State Psychiatric Institute, Biometric Research, New York. 1996;
  14. Fransson P. Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis. Human Brain Mapping. 2005;26:15–29
  15. Greicius MD, Krasnow B, Reiss AL, Menon V. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proceedings of the National Academy of Sciences of the United States of America. 2003;100:253–258
  16. Gur RC, Gur RE. Hypofrontality in schizophrenia: RIP. Lancet. 1995;345:1383–1384
  17. Gusnard DA, Akbdak E, Shulman GL, Raichle ME. Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America. 2001;98:4259–4264
  18. Gusnard DA, Raichle ME. Searching for a baseline: functional imaging and the resting human brain. Nature Reviews. Neuroscience. 2001;2:685–694
  19. Herbener ES, Harrow M, Hill SK. Change in the relationship between anhedonia and functional deficits over a 20-year period in individuals with schizophrenia. Schizophrenia Research. 2005;75:97–105
  20. Hill K, Mann L, Laws KR, Stephenson CM, Nimmo-Smith I, McKenna PJ. Hypofrontality in schizophrenia: a meta-analysis of functional imaging studies. Acta Psychiatrica Scandinavica. 2004;110:243–256
  21. Horan WP, Kring AM, Blanchard JJ. Anhedonia in schizophrenia: a review of assessment strategies. Schizophrenia Bulletin. 2006;32:259–276
  22. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  23. Kim JJ, Mohamed S, Andreasen NC, O'Leary DS, Watkins GL, Ponto LLB, et al. Regional neural dysfunctions in chronic schizophrenia studied with positron emission tomography. American Journal of Psychiatry. 2000;157:542–548
  24. Kircher TT, Liddle PF, Brammer MJ, Williams SC, Murray RM, McGuire PK. Neural correlates of formal thought disorder in schizophrenia: preliminary findings from a functional magnetic resonance imaging study. Archives of General Psychiatry. 2001;58:769–774
  25. Kirkpatrick B, Buchanan RW. Anhedonia and the deficit syndrome of schizophrenia. Psychiatry Research. 1990;31:25–30
  26. Kringelbach ML, Rolls ET. The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. Progress in Neurobiology. 2004;72:341–372
  27. Lahti AC, Holcomb HH, Weiler MA, Medoff DR, Tamminga CA. Functional effects of antipsychotic drugs: comparing clozapine with haloperidol. Biological Psychiatry. 2003;53:601–608
  28. Levitt JJ, McCarley RW, Nestor PG, Petrescu C, Donnino R, Hirayasu Y, et al. Quantitative volumetric MRI study of the cerebellum and vermis in schizophrenia: clinical and cognitive correlates. American Journal of Psychiatry. 1999;156:1105–1107
  29. Loas G, Noisette C, Legrand A, Boyer P. Is anhedonia a specific dimension in chronic schizophrenia?. Schizophrenia Bulletin. 2000;26:495–506
  30. Meehl PE. Schizotaxia, schizotypy, and schizophrenia. American Psychologist. 1962;17:827–838
  31. Mesulam M. From sensation to cognition. Brain. 1998;121:1013–1052
  32. Molina V, Gispert JD, Reig S, Sanz J, Pascau J, Santos A, et al. Cerebral metabolic changes induced by clozapine in schizophrenia and related to clinical improvement. Psychopharmacology. 2005;178:17–26
  33. Potkin SG, Alva G, Fleming K, Anand R, Keator D, Carreon D, et al. A PET study of the pathophysiology of negative symptoms in schizophrenia. American Journal of Psychiatry. 2002;159:227–237
  34. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America. 2001;98:676–682
  35. Rocher AB, Chapon F, Blaizot X, Baron J-C, Chavoix C. Resting-state brain glucose utilization as measured by PET is directly related to regional synaptophysin levels: a study in baboons. Neuroimage. 2003;20:1894–1898
  36. Schmahmann JD. Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. The Journal of Neuropsychiatry and Clinical Neurosciences. 2004;16:367–378
  37. Siegel BV, Buchsbaum MS, Bunney WE, Gottschalk LA, Haier RJ, Lohr JB, et al. Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients. American Journal of Psychiatry. 1993;150:1325–1336
  38. Swinkels A, Giuliano TA. The measurement of conceptualization of mood awareness: monitoring and labeling one's mood states. Personality and Social Psychology Bulletin. 1995;21:934–949
  39. Volkow ND, Wolf AP, Van Gelder P, Brodie JD, Overall JE, Cancro R, et al. Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia. American Journal of Psychiatry. 1987;144:151–158
  40. Weinberger DR, Berman KF. Prefrontal function in schizophrenia: confounds and controversies. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 1996;351:1495–1503
  41. Wild B, Rodden FA, Grodd W, Ruch W. Neural correlates of laughter and humour. Brain. 2003;126:2121–2138
  42. Wise RA. Neuroleptics and operant behavior: the anhedonia hypothesis. Behavioral and Brain Sciences. 1982;5:39–87
  43. Wolkin A, Sanfilipo M, Wolf AP, Angrist B, Brodie JD, Rotrosen J. Negative symptoms and hypofrontality in chronic schizophrenia. Archives of General Psychiatry. 1992;49:959–965

PII: S0925-4927(08)00055-3

doi: 10.1016/j.pscychresns.2008.03.010

Psychiatry Research: Neuroimaging
Volume 171, Issue 3 , Pages 155-165 , 31 March 2009

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