Psychiatry Research: Neuroimaging
Volume 171, Issue 1 , Pages 10-19 , 30 January 2009

Prefrontal myo-inositol concentration and visuospatial functioning among diabetic depressed patients

  • Ebrahim Haroon

      Affiliations

    • Semel Institute of Neurosciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024-1759, USA
    • Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    • ,
  • Kecia Watari

      Affiliations

    • Semel Institute of Neurosciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024-1759, USA
    • ,
  • Albert Thomas

      Affiliations

    • Department of Radiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90024-1759, USA
    • ,
  • Olusola Ajilore

      Affiliations

    • Semel Institute of Neurosciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024-1759, USA
    • ,
  • Jim Mintz

      Affiliations

    • Semel Institute of Neurosciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024-1759, USA
    • ,
  • Virginia Elderkin-Thompson

      Affiliations

    • Semel Institute of Neurosciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024-1759, USA
    • ,
  • Christine Darwin

      Affiliations

    • Department of Clinical Epidemiology and Preventive Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    • ,
  • Senthil Kumaran

      Affiliations

    • Department of Radiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90024-1759, USA
    • ,
  • Anand Kumar

      Affiliations

    • Semel Institute of Neurosciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024-1759, USA
    • Corresponding Author InformationCorresponding author. 760 Westwood Plaza, Rm. C9-938, Los Angeles, CA 90024-1759, USA. Tel.: +1 310 206 4405.

Received 8 August 2007 ,Revised 12 January 2008 ,Accepted 8 March 2008.

References 

  1. Ajilore O, Haroon E, Kumaran S, Darwin C, Binesh N, Mintz J, et al. Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy. Neuropsychopharmacology. 2007;32:1224–1231
  2. Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001;24:1069–1078
  3. Arvanitakis Z, Wilson RS, Bienias JL, Evans DA, Bennett DA. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Archives of Neurology. 2004;61:661–666
  4. Ashwal S, Holshouser B, Tong K, Serna T, Osterdock R, Gross M, et al. Proton spectroscopy detected myoinositol in children with traumatic brain injury. Pediatric.Research. 2004;56:630–638
  5. Beacher F, Simmons A, Daly E, Prasher V, Adams C, Margallo-Lana ML, et al. Hippocampal myo-inositol and cognitive ability in adults with Down syndrome: an in vivo proton magnetic resonance spectroscopy study. Archives of General Psychiatry. 2005;62:1360–1365
  6. Bottomley PA. Spatial localization in NMR spectroscopy in vivo. Annals of New York Academy of Sciences. 1987;508:333–348
  7. Brand A, Richter-Landsberg C, Leibfritz D. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Developmental Neuroscience. 1993;15:289–298
  8. Coupland NJ, Ogilvie CJ, Hegadoren KM, Seres P, Hanstock CC, Allen PS. Decreased prefrontal Myo-inositol in major depressive disorder. Biological.Psychiatry. 2005;57:1526–1534
  9. D'Agostino RB, Wolf PA, Belanger AJ, Kannel WB. Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study. Stroke. 1994;25:40–43
  10. Elderkin-Thompson V, Thomas MA, Binesh N, Mintz J, Haroon E, Dunkin JJ, et al. Brain metabolites and cognitive function among older depressed and healthy individuals using 2D MR spectroscopy. Neuropsychopharmacology. 2004;29:2251–2257
  11. Elderkin-Thompson V, Kumar A, Mintz J, Boone K, Bahng E, Lavretsky H. Executive dysfunction and visuospatial ability among depressed elders in a community setting. Archives of Clinical Neuropsychology. 2004;19:597–611
  12. Haase A, Frahm J, Hanicke W, Matthaei D. 1H NMR chemical shift selective (CHESS) imaging. Physics in Medicine and Biology. 1985;30:341–344
  13. Hassing LB, Grant MD, Hofer SM, Pedersen NL, Nilsson SE, Berg S, et al. Type 2 diabetes mellitus contributes to cognitive decline in old age: a longitudinal population-based study. Journal of International Neuropsychological Society. 2004;10:599–607
  14. Henson R. A mini-review of fMRI studies of human medial temporal lobe activity associated with recognition memory. The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology. 2005;58:340–360
  15. Jones RS, Waldman AD. 1H-MRS evaluation of metabolism in Alzheimer's disease and vascular dementia. Neurological Research. 2004;26:488–495
  16. Kim H, McGrath BM, Silverstone PH. A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI-cycle) to psychiatric disorders-focus on magnetic resonance spectroscopy (MRS) studies. Human Psychopharmacology. 2005;20:309–326
  17. Klose U. In vivo proton spectroscopy in presence of eddy currents. Magnetic Resonance in Medicine. 1990;14:26–30
  18. Kollokia V. Performance analysis of automatic techniques for tissue classification in magnetic resonance images of the human brain. Master's Degree. Concordia University, Montreal: Department of Computer Science; 1996;
  19. Kumar A, Thomas A, Lavretsky H, Yue K, Huda A, Curran J, et al. Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy. American Journal of Psychiatry. 2002;159:630–636
  20. Kumari M, Marmot M. Diabetes and cognitive function in a middle-aged cohort: findings from the Whitehall II study. Neurology. 2005;65:1597–1603
  21. Launer LJ. Epidemiology of white matter lesions. Topics in Magnetic Resonance Imaging: TMRI. 2004;15:365–367
  22. Lesser IM, Boone KB, Mehringer CM, Wohl MA, Miller BL, Berman NG. Cognition and white matter hyperintensities in older depressed patients. American Journal of Psychiatry. 1996;153:1280–1287
  23. Linn BJ, Linn BW, Gurel L. Cumulative Illness Rating Scale. Journal of American Geriatrics Society. 1968;16:622–626
  24. Lucas, J.A., 2005. Disorders of memory. Psychiatric Clinics of North America 28, 581–97, 594.
  25. Luchsinger JA, Tang MX, Stern Y, Shea S, Mayeux R. Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort. American Journal of Epidemiology. 2001;154:635–641
  26. Lustman PJ, Anderson RJ, Freedland KE, de GM, Carney RM, Clouse RE. Depression and poor glycemic control: a meta-analytic review of the literature. Diabetes Care. 2000;23:934–942
  27. Meyers JL, Meyers KR. Rey complex figure. Test and recognition trial (RCFT), Professional Manual. Florida: Psychological Assessment Resources; 1996;
  28. Nguyen TT, Wong TY, Islam FM, Hubbard L, Miller J, Haroon E, et al. Is depression associated with microvascular disease in patients with type 2 diabetes?. Depression and Anxiety. 2008;25(11):E158–E162
  29. Osterrieth PA. Le test de copie dune figure complexe. Archives de Psycghologie. 1944;30:206–356
  30. Oz G, Tkac I, Charnas LR, Choi IY, Bjoraker KJ, Shapiro EG, et al. Assessment of adrenoleukodystrophy lesions by high field MRS in non-sedated pediatric patients. Neurology. 2005;64:434–441
  31. Provencher SW. Estimations of metabolite concentrations from localized in vivo proton NMR spectra. Magnetic Resonance in Medicine. 1993;30:672–679
  32. Ranganath C. Working memory for visual objects: complementary roles of inferior temporal, medial temporal, and prefrontal cortex. Neuroscience. 2006;139:277–289
  33. Rey A. L'examen psychologique dans les cas d'encephalopathie traumatique. Archives de Psychologie. 1941;28:286–340
  34. Robertson NJ, Lewis RH, Cowan FM, Allsop JM, Counsell SJ, Edwards AD, et al. Early increases in brain myo-inositol measured by proton magnetic resonance spectroscopy in term infants with neonatal encephalopathy. Pediatric Research. 2001;50:692–700
  35. Schupf N, Tang MX, Albert SM, Costa R, Andrews H, Lee JH, et al. Decline in cognitive and functional skills increases mortality risk in nondemented elderly. Neurology. 2005;65:1218–1226
  36. Strachan MW, Deary IJ, Ewing FM, Frier BM. Is type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies. Diabetes Care. 1997;20:438–445
  37. Thomas MA, Yue K, Binesh N, Davanzo P, Kumar A, Siegel B, et al. Localized two-dimensional shift correlated MR spectroscopy of human brain. Magnetic Resonance in Medicine. 2001;46:58–67
  38. van der Graaf M, Janssen SW, van Asten JJ, Hermus AR, Sweep CG, Pikkemaat JA, et al. Metabolic profile of the hippocampus of Zucker diabetic fatty rats assessed by in vivo 1H magnetic resonance spectroscopy. NMR in Biomedicine. 2004;17:405–410
  39. Watari K, Letamendi A, Elderkin-Thompson V, Haroon E, Miller J, Darwin C, et al. Cognitive function in adults with type 2 diabetes and major depression. Archives of Clinical Neuropsychology. 2006;21:787–796

PII: S0925-4927(08)00049-8

doi: 10.1016/j.pscychresns.2008.03.006

Psychiatry Research: Neuroimaging
Volume 171, Issue 1 , Pages 10-19 , 30 January 2009

Article Tools

* Image Usage & Resolution