Psychiatry Research: Neuroimaging
Volume 171, Issue 2 , Pages 82-93 , 28 February 2009

Reduced language lateralization in first-episode schizophrenia: An fMRI index of functional asymmetry

  • Maya Bleich-Cohen

      Affiliations

    • Functional Brain Imaging Unit, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Israel
    • Levi-Edersheim-Gitter Institute for Human Brain Mapping, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Corresponding Author InformationCorresponding author. Functional Brain Imaging Unit, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel. Tel.: +972 3 6973094; fax: +972 3 6973080.
    • The authors contributed equally.
    • ,
  • Talma Hendler

      Affiliations

    • Functional Brain Imaging Unit, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Israel
    • Levi-Edersheim-Gitter Institute for Human Brain Mapping, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • The authors contributed equally.
    • ,
  • Moshe Kotler

      Affiliations

    • Beer Yaakov Mental Health Center, Beer Yaakov, Sackler Faculty of Medicine, Tel Aviv University, Israel
    • ,
  • Rael D. Strous

      Affiliations

    • Beer Yaakov Mental Health Center, Beer Yaakov, Sackler Faculty of Medicine, Tel Aviv University, Israel

Received 20 May 2007 ,Revised 18 December 2007 ,Accepted 4 March 2008.

References 

  1. Andreasen NC, Dennert JW, Olsen SA, Damasio AR. Hemispheric asymmetries and schizophrenia. American Journal of Psychiatry. 1982;139:427–430
  2. Annett M. Parallels between asymmetries of planum temporale and of hand skill. Neuropsychologia. 1992;30:951–962
  3. Barta PE, Pearlson GD, Brill LB, Royall R, McGilchrist IK, Pulver AE, et al. Planum temporale asymmetry reversal in schizophrenia: replication and relationship to gray matter abnormalities. American Journal of Psychiatry. 1997;154:661–667
  4. Bilder RM, Wu H, Bogerts B, Degreef G, Ashtari M, Alvir JM, et al. Absence of regional hemispheric volume asymmetries in first-episode schizophrenia. American Journal of Psychiatry. 1994;151:1437–1447
  5. Bruder G, Rabinowicz E, Towey J, Brown A, Kaufmann CA, Amador X, et al. Smaller right ear (left hemisphere) advantage for dichotic fused words in patients with schizophrenia. American Journal of Psychiatry. 1995;152:932–935
  6. Crespo-Facorro B, Kim JJ, Chemerinski E, Magnotta V, Andreasen NC, Nopoulos P. Morphometry of the superior temporal plane in schizophrenia: relationship to clinical correlates. Journal of Neuropsychiatry and Clinical Neuroscience. 2004;16:284–294
  7. Crow TJ, Colter N, Frith CD, Johnstone EC, Owens DG. Developmental arrest of cerebral asymmetries in early onset schizophrenia. Psychiatry Research. 1989;29:247–253
  8. Crow TJ, Done DJ, Sacker A. Cerebral lateralization is delayed in children who later develop schizophrenia. Schizophrenia Research. 1996;22:181–185
  9. Desmond JE, Sum JM, Wagner AD, Demb JB, Shear PK, Glover GH, et al. Functional MRI measurement of language lateralization in Wada-tested patients. Brain. 1995;118:1411–1419
  10. Dollfus S, Razafimandimby A, Delamillieure P, Brazo P, Joliot M, Mazoyer B, et al. Atypical hemispheric specialization for language in right-handed schizophrenia patients. Biological Psychiatry. 2005;57:1020–1028
  11. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition (SCID-P), Version 2. New York State Psychiatric Institute, New York: Biometrics Research; 1994;
  12. Falkai P, Bogerts B. Neurodevelopmental abnormalities in schizophrenia. Clin Neuropharmacological Supplementary. 1992;1(Pt A):498A–499A
  13. Falkai P, Bogerts B, Schneider T, Greve B, Pfeiffer U, Pilz K, et al. Disturbed planum temporale asymmetry in schizophrenia. A quantitative post-mortem study. Schizophrenia Research. 1995;14:161–176
  14. Grosh ES, Docherty NM, Wexler BE. Abnormal laterality in schizophrenias and their parents. Schizophrenia Research. 1995;14:155–160
  15. Guy W. ECDEU Assessment Manual for Psychopharmacology. In: U.S. Department of Health, Education, and Welfare Publication (ADM) 76-338. Rockville MD: National Institute of Mental Health; 1976;p. 218–222
  16. Hirayasu Y, McCarley RW, Salisbury DF, Tanaka S, Kwon JS, Frumin M, et al. Planum temporale and Heschl gyrus volume reduction in schizophrenia: a magnetic resonance imaging study of first-episode patients. Archives of General Psychiatry. 2000;57:692–699
  17. Hutsler J, Galuske RA. Hemispheric asymmetries in cerebral cortical networks. Trends in Neuroscience. 2003;26:429–435
  18. Jernigan TL, Zatz LM, Moses JA, Cardellino JP. Computed tomography in schizophrenias and normal volunteers. II. Cranial asymmetry. Archives of General Psychiatry. 1982;39:771–773
  19. Kasai K, Shenton ME, Salisbury DF, Hirayasu Y, Lee CU, Ciszewski AA, et al. Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia. American Journal of Psychiatry. 2003;160:156–164
  20. Kay S, Fiszbein A, Opler LA. The positive and negative syndrome scale for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  21. Kloppel S, Buchel C. Alternatives to the Wada test: a critical view of functional magnetic resonance imaging in preoperative use. Current Opinion in Neurology. 2005;18:418–423
  22. Leitman DI, Hoptman MJ, Foxe JJ, Saccente E, Wylie GR, Nierenberg J, et al. The neural substrates of impaired prosodic detection in schizophrenia and its sensorial antecedents. American Journal of Psychiatry. 2007;164:474–482
  23. Luchins DJ, Morihisa JM, Weinberger DR, Wyatt RJ. Cerebral asymmetry and cerebellar atrophy in schizophrenia: a controlled postmortem study. American Journal of Psychiatry. 1981;138:1501–1503
  24. Matsumoto H, Simmons A, Williams S, Hadjulis M, Pipe R, Murray R, et al. Superior temporal gyrus abnormalities in early-onset schizophrenia: similarities and differences with adult-onset schizophrenia. American Journal of Psychiatry. 2001;158:1299–1304
  25. McGuire PK, Quested DJ, Spence SA, Murray RM, Frith CD, Liddle PF. Pathophysiology of ‘positive’ thought disorder in schizophrenia. British Journal of Psychiatry. 1998;173:231–235
  26. Shenton ME, Kikinis R, Jolesz FA, Pollak SD, LeMay M, Wible CG, et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. New England Journal of Medicine. 1992;27:604–612
  27. Sommer I, Ramsey N, Kahn R, Aleman A, Bouma A. Handedness, language lateralisation and anatomical asymmetry in schizophrenia: meta-analysis. British Journal of Psychiatry. 2001;178:344–351
  28. Sommer IE, Ramsey NF, Kahn RS. Language lateralization in schizophrenia, an fMRI study. Schizophrenia Research. 2001;52:57–67
  29. Sommer IE, Ramsey NF, Mandl RC, Kahn RS. Language lateralization in female patients with schizophrenia: an fMRI study. Schizophrenia Research. 2003;60:183–190
  30. Sumich A, Chitnis XA, Fannon DG, O'Ceallaigh S, Doku VC, Falrowicz A, et al. Temporal lobe abnormalities in first-episode psychosis. American Journal of Psychiatry. 2002;159:1232–1235
  31. Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry. 1987;44:660–669
  32. Weiss EM, Hofer A, Golaszewski S, Siedentopf C, Brinkhoff C, Kremser C, et al. Brain activation patterns during a verbal fluency test—a functional MRI study in healthy volunteers and patients with schizophrenia. Schizophrenia Research. 2004;70:287–291
  33. Weiss EM, Hofer A, Golaszewski S, Siedentopf C, Felber S, Fleischhacker WW. Language lateralization in unmedicated patients during an acute episode of schizophrenia: a functional MRI study. Psychiatry Research: Neuroimaging. 2006;146:185–190
  34. Wexler BE, Giller EL, Southwick S. Cerebral laterality, symptoms, and diagnosis in psychotic patients. Biological Psychiatry. 1991;29:103–116
  35. Yan SM, Flor-Henry P, Chen DY, Li TG, Qi SG, Ma ZX. Imbalance of hemispheric functions in the major psychosis: a study of handedness in the People's Republic of China. Biological Psychiatry. 1985;20:906–917

PII: S0925-4927(08)00046-2

doi: 10.1016/j.pscychresns.2008.03.002

Psychiatry Research: Neuroimaging
Volume 171, Issue 2 , Pages 82-93 , 28 February 2009

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