Psychiatry Research: Neuroimaging
Volume 171, Issue 2 , Pages 94-105 , 28 February 2009

Neural correlates of episodic and semantic memory retrieval in borderline personality disorder: An fMRI study

  • Christoph Mensebach

      Affiliations

    • Department of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Bielefeld, Germany
    • University of Bielefeld, Department of Psychology, Bielefeld, Germany
    • Corresponding Author InformationCorresponding author. Department of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Remterweg 69-71, D-33617 Bielefeld, Germany. Tel.: +49 521 772 78521; fax: +49 521 772 78511.
  • ,
  • Thomas Beblo

      Affiliations

    • Department of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Bielefeld, Germany
    • University of Bielefeld, Department of Psychology, Bielefeld, Germany
  • ,
  • Martin Driessen

      Affiliations

    • Department of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Bielefeld, Germany
    • University of Bielefeld, Department of Psychology, Bielefeld, Germany
    • University Schleswig-Holstein, Campus Luebeck, Germany
  • ,
  • Katja Wingenfeld

      Affiliations

    • Department of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Bielefeld, Germany
  • ,
  • Markus Mertens

      Affiliations

    • MRI Unit, Mara Hospital, Bethel Epilepsy Center, Ev. Hospital Bielefeld, Bielefeld, Germany
  • ,
  • Nina Rullkoetter

      Affiliations

    • Department of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Bielefeld, Germany
    • University of Bielefeld, Department of Psychology, Bielefeld, Germany
  • ,
  • Wolfgang Lange

      Affiliations

    • Department of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Bielefeld, Germany
  • ,
  • Hans J. Markowitsch

      Affiliations

    • University of Bielefeld, Department of Psychology, Bielefeld, Germany
  • ,
  • Isabella Ollech

      Affiliations

    • MRI Unit, Mara Hospital, Bethel Epilepsy Center, Ev. Hospital Bielefeld, Bielefeld, Germany
  • ,
  • Anamaria Silva Saveedra

      Affiliations

    • Department of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Bielefeld, Germany
    • University of Bielefeld, Department of Psychology, Bielefeld, Germany
  • ,
  • Harald Rau

      Affiliations

    • Department of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Bielefeld, Germany
  • ,
  • Friedrich G. Woermann

      Affiliations

    • MRI Unit, Mara Hospital, Bethel Epilepsy Center, Ev. Hospital Bielefeld, Bielefeld, Germany

Received 1 February 2006 ,Revised 24 April 2007 ,Accepted 18 February 2008.

References 

  1. Beblo T, Silva Saavedra A, Mensebach C, Driessen M. Psychophysiological and neuropsychological deviations in trauma-related disorders: borderline personality disorder and posttraumatic stress disorder. In:  Corales TA editors. Focus on Posttraumatic Stress Disorder Research. Hauppauge, NY: Nova Publishers; 2004;p. 51–70
  2. Beblo T, Driessen M, Mertens M, Wingenfeld K, Piefke M, Rullkoetter N, et al. fMRI correlates of the recall of unresolved life events in borderline personality disorder. Psychological Medicine. 2006;36:845–854
  3. Beblo T, Silva Saavedra A, Mensebach C, Lange W, Markowitsch HJ, Rau H, et al. Deficits in visual functions and neuropsychological inconsistency in borderline personality disorder. Psychiatry Research. 2006;145:127–135
  4. Beck AT, Steer RA. Beck-Depressions-Inventar (BDI): Testhandbuch. Bern: Huber; 1994;
  5. Brambilla P, Soloff PH, Sala M, Nicoletti MA, Keshavan MS, Soares JC. Anatomical MRI study of borderline personality disorder patients. Psychiatry Research. Neuroimaging. 2004;131:125–133
  6. Buckner RL. Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. Neuron. 2004;44:195–208
  7. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences. 2000;4:215–222
  8. Cabeza R, Nyberg L. Imaging cognition II: an empirical review of 275 PET and fMRI studies. Journal of Cognitive Neuroscience. 2000;12:1–47
  9. Cabeza R, Anderson ND, Locantore JK, McIntosh AR. Aging gracefully: compensatory brain activity in high-performing older adults. Neuroimage. 2002;17:1394–1402
  10. Cabeza R, Dolcos F, Prince SE, Rice HJ, Weissman DH, Nyberg L. Attention-related activity during episodic memory retrieval: a cross-function fMRI study. Neuropsychologia. 2003;41:390–399
  11. Chein JM, Ravizza SM, Fiez JA. Using neuroimaging to evaluate models of working memory and their implications for language processing. Journal of Neurolinguistics. 2003;16:315–339
  12. De La Fuente JM, Goldman S, Stanus E, Vizuete C, Morlan I, Bobes J, et al. Brain glucose metabolism in borderline personality disorder. Journal of Psychiatric Research. 1997;31:531–541
  13. Donegan NH, Sanislow CA, Blumberg HP, Fulbright RK, Lacadie C, Skudlarski P, et al. Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation. Biological Psychiatry. 2003;54:1284–1293
  14. Driessen M, Herrmann J, Stahl K, Zwaan M, Meier S, Hill A, et al. Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization. Archives of General Psychiatry. 2000;57:1115–1122
  15. Driessen M, Beblo T, Mertens M, Piefke M, Rullkoetter N, Silva-Saavedra A, et al. Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder. Biological Psychiatry. 2004;55:603–611
  16. Fertuck EA, Lenzenweger MF, Clarkin JF, Hoermann S, Stanley B. Executive neurocognition, memory systems, and borderline personality disorder. Clinical Psychology Review. 2006;26:346–375
  17. Fletcher PC, Frith CD, Grasby PM, Shallice T, Frackowiak RS, Dolan RJ. Brain systems for encoding and retrieval of auditory-verbal memory. An in vivo study in humans. Brain. 1995;118:401–416
  18. Friederici AD, Ruschemeyer SA, Hahne A, Fiebach CJ. The role of left inferior frontal and superior temporal cortex in sentence comprehension: localizing syntactic and semantic processes. Cerebral Cortex. 2003;13:170–177
  19. Friston KJ, Holmes AP, Worsley KJ. How many subjects constitute a study?. Neuroimage. 1999;10:1–5
  20. Gazzaniga MS, Ivry RB, Mangun GR. Cognitive Neuroscience. New York: W.W. Norton and Company; 1998;
  21. Hamilton M. Hamilton depression scale. In:  Scalarum CIP editors. Internationale Skalen für die Psychiatrie. Beltz, Göttingen. 1996;
  22. Hazlett EA, New AS, Newmark R, Haznedar MM, Lo JN, Speiser LJ, et al. Reduced anterior and posterior cingulate gray matter in borderline personality disorder. Biological Psychiatry. 2005;58:614–623
  23. Helmstaedter C, Lendt M, Lux S. Verbaler Lern- und Merkfaehigkeitstest. Goettingen: Beltz; 2003;
  24. Herpertz SC, Dietrich TM, Wenning B, Krings T, Erberich SG, Willmes K, et al. Evidence of abnormal amygdala functioning in borderline personality disorder: a functional MRI study. Biological Psychiatry. 2001;50:292–298
  25. Irle E, Lange C, Sachsse U. Reduced size and abnormal asymmetry of parietal cortex in women with borderline personality disorder. Biological Psychiatry. 2005;57:173–182
  26. Juengling FD, Schmahl C, Hesslinger B, Ebert D, Bremner JD, Gostomzyk J, et al. Positron emission tomography in female patients with borderline personality disorder. Journal of Psychiatric Research. 2003;37:109–115
  27. Kernberg OF, Dulz B, Sachsse U. Handbuch der Borderline-Stoerungen. Stuttgart: Schattauer; 2000;
  28. Kobayashi Y, Amaral DG. Macaque monkey retrosplenial cortex: II. Cortical afferents. Journal of Comparative Neurology. 2003;466:48–79
  29. Kunert HJ, Druecke HW, Sass H, Herpertz SC. Frontal lobe dysfunctions in borderline personality disorder? Neuropsychological findings. Journal of Personality Disorders. 2003;17:497–509
  30. Lange C, Kracht L, Herholz K, Sachsse U, Irle E. Reduced glucose metabolism in temporo-parietal cortices of women with borderline personality disorder. Psychiatry Research. Neuroimaging. 2005;139:115–126
  31. Lezak MD. Neuropsychological Assessment. New York: Oxford University Press; 1995;
  32. Lyoo IK, Han MH, Cho DY. A brain MRI study in subjects with borderline personality disorder. Journal of Affective Disorders. 1998;50:235–243
  33. Maercker A, Schuetzwohl M. Erfassung von psychischen Belastungsfolgen: Die Impact of Event Skala - revidierte Version (IES-R). Diagnostica. 1998;44:130–141
  34. Markowitsch HJ. Memory and amnesia. In:  Mesulam M-M editors. Principles of cognitive and behavioural neurology. New York: Oxford University Press; 2000;p. 257–293
  35. Markowitsch HJ. The neuroanatomy of memory. In:  Halligan P,  Wade P editor. The effectiveness of rehabilitation for cognitive deficits. Oxford: Oxford University Press; 2005;p. 105–114
  36. Monarch ES, Saykin AJ, Flashman LA. Neuropsychological impairment in borderline personality disorder. The Psychiatric Clinics of North America. 2004;27:67–82viii-ix
  37. Mummery CJ, Patterson K, Hodges JR, Price CJ. Functional neuroanatomy of the semantic system: divisible by what?. Journal of Cognitive Neuroscience. 1998;10:766–777
  38. Naghavi HR, Nyberg L. Common fronto-parietal activity in attention, memory, and consciousness: shared demands on integration?. Consciousness and Cognition. 2005;14:390–425
  39. O'Leary KM, Brouwers P, Gardner DL, Cowdry RW. Neuropsychological testing of patients with borderline personality disorder. American Journal of Psychiatry. 1991;148:106–111
  40. Paris J. The diagnoses of borderline personality disorder: problematic but better than the alternatives. Annals of Clinical Psychiatry. 2005;17:41–46
  41. Piefke M, Weiss PH, Zilles K, Markowitsch HJ, Fink GR. Differential remoteness and emotional tone modulate the neural correlates of autobiographical memory. Brain. 2003;126:650–668
  42. Price CJ. The anatomy of language: contributions from functional neuroimaging. Journal of Anatomy. 2000;197:335–359
  43. Ravizza SM, Delgado MR, Chein JM, Becker JT, Fiez JA. Functional dissociations within the inferior parietal cortex in verbal working memory. Neuroimage. 2004;22:562–573
  44. Reinhold N, Brand M, Markowitsch HJ. Functional neuroimaging in memory and memory disturbences. Current Medical Imaging Reviews. 2006;2:35–57
  45. Ruocco AC. The neuropsychology of borderline personality disorder: a meta-analysis and review. Psychiatry Research. 2005;137:191–202
  46. Rusch N, van Elst LT, Ludaescher P, Wilke M, Huppertz HJ, Thiel T, et al. A voxel-based morphometric MRI study in female patients with borderline personality disorder. Neuroimage. 2003;20:385–392
  47. Schmahl CG, Bremner JD. Neuroimaging in borderline personality disorder. Journal of Psychiatric Research. 2006;14:419–427
  48. Schmahl CG, Elzinga BM, Vermetten E, Sanislow C, McGlashan TH, Bremner JD. Neural correlates of memories of abandonment in women with and without borderline personality disorder. Biological Psychiatry. 2003;54:142–151
  49. Schmahl CG, Vermetten E, Elzinga BM, Bremner JD. Magnetic resonance imaging of hippocampal and amygdala volume in women with childhood abuse and borderline personality disorder. Psychiatry Research. Neuroimaging. 2003;122:193–198
  50. Schmahl CG, Vermetten E, Elzinga BM, Bremner JD. A positron emission tomography study of memories of childhood abuse in borderline personality disorder. Biological Psychiatry. 2004;55:759–765
  51. Schmithorst VJ, Holland SK, Plante E. Cognitive modules utilized for narrative comprehension in children: a functional magnetic resonance imaging study. Neuroimage. 2006;29:254–266
  52. Shivde G, Thompson-Schill SL. Dissociating semantic and phonological maintenance using fMRI. Cognitive, Affective, and Behavioral Neuroscience. 2004;4:10–19
  53. Soloff PH, Meltzer CC, Becker C, Greer PJ, Kelly TM, Constantine D. Impulsivity and prefrontal hypometabolism in borderline personality disorder. Psychiatry Research. Neuroimaging. 2003;123:153–163
  54. Sprock J, Rader TJ, Kendall JP, Yoder CY. Neuropsychological functioning in patients with borderline personality disorder. Journal of Clinical Psychology. 2000;56:1587–1600
  55. Sternbach SE, Judd PH, Sabo AN, McGlashan T, Gunderson JG. Cognitive and perceptual distortions in borderline personality disorder and schizotypal personality disorder in a vignette sample. Comprehensive Psychiatry. 1992;33:186–189
  56. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. In: 3-dimensional proportional system: An approach to cerebral imaging. Stuttgart: Thieme; 1988;
  57. Takayama Y, Kinomoto K, Nakamura K. Selective impairment of the auditory-verbal short-term memory due to a lesion of the superior temporal gyrus. European Neurology. 2004;51:115–117
  58. Tebartz van Elst L, Hesslinger B, Thiel T, Geiger E, Haegele K, Lemieux L, et al. Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study. Biological Psychiatry. 2003;54:163–171
  59. Thompson-Schill SL. Neuroimaging studies of semantic memory: inferring “how” from “where”. Neuropsychologia. 2003;41:280–292
  60. Valenstein E, Bowers D, Verfaellie M, Heilman KM, Day A, Watson RT. Retrosplenial amnesia. Brain. 1987;110:1631–1646
  61. Vogt BA, Finch DM, Olson CR. Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cerebral Cortex. 1992;2:435–443
  62. Vogt BA, Vogt L, Laureys S. Cytology and functionally correlated circuits of the human posterior cingulate areas. Neuroimage. 2006;29:452–466
  63. Vollm B, Richardson P, Stirling J, Elliott R, Dolan M, Chaudhry I, et al. Neurobiological substrates of antisocial and borderline personality disorder: preliminary results of a functional fMRI study. Criminal Behaviour and Mental Health. 2004;14:39–54
  64. Wagner AD, Desmond JE, Glover GH, Gabrieli JD. Prefrontal cortex and recognition memory. Functional-MRI evidence for context-dependent retrieval processes. Brain. 1998;121:1985–2002
  65. Wagner AD, Shannon BJ, Kahn I, Buckner RL. Parietal lobe contributions to episodic memory retrieval. Trends in Cognitive Sciences. 2005;9:445–453
  66. Wittchen HU, Zaudig M, Fydrich T. SKID - Strukturiertes Klinisches Interview fuer DSM-IV. In: Achse I und II. Handanweisungen. Goettingen: Hogrefe-Verlag; 1997;
  67. Zanarini MC, Gunderson JG, Frankenburg FR. Cognitive features of borderline personality disorder. American Journal of Psychiatry. 1990;147:57–63

PII: S0925-4927(08)00043-7

doi: 10.1016/j.pscychresns.2008.02.006

Psychiatry Research: Neuroimaging
Volume 171, Issue 2 , Pages 94-105 , 28 February 2009