Psychiatry Research: Neuroimaging
Volume 171, Issue 3 , Pages 199-206 , 31 March 2009

A continuous emotional task activates the left amygdala in healthy volunteers: 18FDG PET study

  • Emilio Fernandez-Egea

      Affiliations

    • Hospital Clinic Schizophrenia Program (PEC), Department of Psychiatry, Institute of Neuroscience, Hospital Clinic, Barcelona, Spain
    • Corresponding Author InformationCorresponding author. Servei de Psiquiatría (G096), Institut Clínic de Neurociències, Hospital Clínic, C/Villarroel, 170, 08036 Barcelona, Spain. Tel.: +34 93 227 55 47; fax: +34 93 227 55 48.
    • ,
  • Eduard Parellada

      Affiliations

    • Hospital Clinic Schizophrenia Program (PEC), Department of Psychiatry, Institute of Neuroscience, Hospital Clinic, Barcelona, Spain
    • Institut d'Investigacions Biomèdiques Augusti Pi i Sunyer (IDIBAPS), Barcelona, Spain
    • ,
  • Francisco Lomeña

      Affiliations

    • Nuclear Medicine, Institut de Diagnostic per Imatge, Hospital Clinic, Barcelona, Spain
    • Institut d'Investigacions Biomèdiques Augusti Pi i Sunyer (IDIBAPS), Barcelona, Spain
    • ,
  • Carles Falcon

      Affiliations

    • Unitat de Biofísica i Bioengineria, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    • Institut d'Investigacions Biomèdiques Augusti Pi i Sunyer (IDIBAPS), Barcelona, Spain
    • Centro de Investigación Biomédica en Red en Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Spain
    • ,
  • Javier Pavia

      Affiliations

    • Nuclear Medicine, Institut de Diagnostic per Imatge, Hospital Clinic, Barcelona, Spain
    • Institut d'Investigacions Biomèdiques Augusti Pi i Sunyer (IDIBAPS), Barcelona, Spain
    • Centro de Investigación Biomédica en Red en Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Spain
    • ,
  • Anna Mane

      Affiliations

    • Hospital Clinic Schizophrenia Program (PEC), Department of Psychiatry, Institute of Neuroscience, Hospital Clinic, Barcelona, Spain
    • ,
  • Gisela Sugranyes

      Affiliations

    • Hospital Clinic Schizophrenia Program (PEC), Department of Psychiatry, Institute of Neuroscience, Hospital Clinic, Barcelona, Spain
    • ,
  • Manuel Valdes

      Affiliations

    • Hospital Clinic Schizophrenia Program (PEC), Department of Psychiatry, Institute of Neuroscience, Hospital Clinic, Barcelona, Spain
    • Institut d'Investigacions Biomèdiques Augusti Pi i Sunyer (IDIBAPS), Barcelona, Spain
    • ,
  • Miguel Bernardo

      Affiliations

    • Hospital Clinic Schizophrenia Program (PEC), Department of Psychiatry, Institute of Neuroscience, Hospital Clinic, Barcelona, Spain
    • Institut d'Investigacions Biomèdiques Augusti Pi i Sunyer (IDIBAPS), Barcelona, Spain

Received 14 May 2007 ,Revised 17 December 2007 ,Accepted 12 January 2008.

References 

  1. Abel KM, Allin MP, Kucharska-Pietura K, David A, Andrew C, Williams S, et al. Ketamine alters neural processing of facial emotion recognition in healthy men: an fMRI study. Neuroreport. 2003;14:387–391
  2. Adolphs R, Tranel D, Damasio H, Damasio A. Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala. Nature. 1994;372:669–672
  3. Baas D, Aleman A, Kahn RS. Lateralization of amygdala activation: a systematic review of functional neuroimaging studies. Brain Research Brain Research Reviews. 2004;45:96–103
  4. Bonson KR, Grant SJ, Contoreggi CS, Links JM, Metcalfe J, Weyl HL, et al. Neural systems and cue-induced cocaine craving. Neuropsychopharmacology. 2002;26:376–386
  5. Breiter HC, Etcoff NL, Whalen PJ, Kennedy WA, Rauch SL, Buckner RL, et al. Response and habituation of the human amygdala during visual processing of facial expression. Neuron. 1996;17:875–887
  6. Buchanan TW, Lutz K, Mirzazade S, Specht K, Shah NJ, Zilles K, et al. Recognition of emotional prosody and verbal components of spoken language: an fMRI study. Brain Research Cognitive Brain Research. 2000;9:227–238
  7. Cahill L, Haier RJ, White NS, Fallon J, Kilpatrick L, Lawrence C, et al. Sex-related difference in amygdala activity during emotionally influenced memory storage. Neurobiology of Learning and Memory. 2001;75:1–9
  8. Calder AJ, Young AW. Understanding the recognition of facial identity and facial expression. Nature Reviews Neuroscience. 2005;6:641–651
  9. Davis M, Whalen PJ. The amygdala: vigilance and emotion. Molecular Psychiatry. 2001;6:13–34
  10. Dolan RJ. Emotion, cognition, and behavior. Science. 2002;298:1191–1194
  11. Edwards J, Jackson HJ, Pattison PE. Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review. Clinical.Psychology Review. 2002;22:789–832
  12. Fischer H, Furmark T, Wik G, Fredrikson M. Brain representation of habituation to repeated complex visual stimulation studied with PET. Neuroreport. 2000;11:123–126
  13. Fitzgerald DA, Angstadt M, Jelsone LM, Nathan PJ, Phan KL. Beyond threat: amygdala reactivity across multiple expressions of facial affect. Neuroimage. 2006;30:1441–1448
  14. Friston KJ, Rotshtein P, Geng JJ, Sterzer P, Henson RN. A critique of functional localisers. Neuroimage. 2006;30:1077–1087
  15. Grant S, London ED, Newlin DB, Villemagne VL, Liu X, Contoreggi C, et al. Activation of memory circuits during cue-elicited cocaine craving. Proceedings of the National Academy of Sciences of the United States of America. 1996;93:12040–12045
  16. Gur RC, Sara R, Hagendoorn M, Marom O, Hughett P, Macy L, et al. A method for obtaining 3-dimensional facial expressions and its standardization for use in neurocognitive studies. Journal of Neuroscience Methods. 2002;115:137–143
  17. Gur RC, Schroeder L, Turner T, McGrath C, Chan RM, Turetsky BI, et al. Brain activation during facial emotion processing. Neuroimage. 2002;16:651–662
  18. Gur RE, McGrath C, Chan RM, Schroeder L, Turner T, Turetsky BI, et al. An fMRI study of facial emotion processing in patients with schizophrenia. American Journal of Psychiatry. 2002;159:1992–1999
  19. Hariri AR, Tessitore A, Mattay VS, Fera F, Weinberger DR. The amygdala response to emotional stimuli: a comparison of faces and scenes. Neuroimage. 2002;17:317–323
  20. Holt DJ, Weiss AP, Rauch SL, Wright CI, Zalesak M, Goff DC, et al. Sustained activation of the hippocampus in response to fearful faces in schizophrenia. Biological Psychiatry. 2005;57:1011–1019
  21. Holt DJ, Titone D, Long LS, Goff DC, Cather C, Rauch SL, et al. The misattribution of salience in delusional patients with schizophrenia. Schizophrenia Research. 2006;83:247–256
  22. Kosaka H, Omori M, Murata T, Iidaka T, Yamada H, Okada T, et al. Differential amygdala response during facial recognition in patients with schizophrenia: an fMRI study. Schizophrenia Research. 2002;57:87–95
  23. Liu J, Harris A, Kanwisher N. Stages of processing in face perception: an MEG study. Nature Neuroscience. 2002;5:910–916
  24. London ED, Stapleton JM, Phillips RL, Grant SJ, Villemagne VL, Liu X, et al. PET studies of cerebral glucose metabolism: acute effects of cocaine and long-term deficits in brains of drug abusers. NIDA Research Monographs. 1996;163:146–158
  25. Mackiewicz KL, Sarinopoulos I, Cleven KL, Nitschke JB. The effect of anticipation and the specificity of sex differences for amygdale and hippocampus function in emotional memory. Proceedings of the National Academy of Sciences of the United States of America. 2006;103:14,200–14,205
  26. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 2003;19:1233–1239
  27. Martin A. Automatic activation of the medial temporal lobe during encoding: lateralized influences of meaning and novelty. Hippocampus. 1999;9:62–70
  28. Minzenberg MJ, Fan J, New AS, Tang CY, Siever LJ. Fronto-limbic dysfunction in response to facial emotion in borderline personality disorder: an event-related fMRI study. Psychiatry Research: Neuroimaging. 2007;155:231–243
  29. Phan KL, Wager T, Taylor SF, Liberzon I. Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. Neuroimage. 2002;16:331–348
  30. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception I: the neural basis of normal emotion perception. Biological.Psychiatry. 2003;54:504–514
  31. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: implications for major psychiatric disorders. Biological Psychiatry. 2003;54:515–528
  32. Reiman EM, Lane RD, Ahern GL, Schwartz GE, Davidson RJ, Friston KJ, et al. Neuroanatomical correlates of externally and internally generated human emotion. American Journal of Psychiatry. 1997;154:918–925
  33. Rilling JK, Winslow JT, Kilts CD. The neural correlates of mate competition in dominant male rhesus macaques. Biological Psychiatry. 2004;56:364–375
  34. Sarro S, Duenas RM, Ramirez N, Arranz B, Martinez R, Sanchez JM, et al. Cross-cultural adaptation and validation of the Spanish version of the Calgary depression scale for schizophrenia. Schizophrenia Research. 2004;68:349–356
  35. Saxe R, Brett M, Kanwisher N. Divide and conquer: a defense of functional localizers. Neuroimage. 2006;30:1088–1096
  36. Sheline YI, Barch DM, Donnelly JM, Ollinger JM, Snyder AZ, Mintun MA. Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biological Psychiatry. 2001;50:651–658
  37. Silver H, Shlomo N, Turner T, Gur RC. Perception of happy and sad facial expressions in chronic schizophrenia: evidence for two evaluative systems. Schizophrenia Research. 2002;55:171–177
  38. Streit M, Dammers J, Simsek-Kraues S, Brinkmeyer J, Wolwer W, Ioannides A. Time course of regional brain activations during facial emotion recognition in humans. Neuroscience Letters. 2003;342:101–104
  39. Takahashi H, Koeda M, Oda K, Matsuda T, Matsushima E, Matsuura M, et al. An fMRI study of differential neural response to affective pictures in schizophrenia. Neuroimage. 2004;22:1247–1254
  40. Takahashi H, Matsuura M, Yahata N, Koeda M, Suhara T, Okubo Y. Men and women show distinct brain activations during imagery of sexual and emotional infidelity. Neuroimage. 2006;32:1299–1307
  41. Taylor SF, Liberzon I, Decker LR, Koeppe RA. A functional anatomic study of emotion in schizophrenia. Schizophrenia Research. 2002;58:159–172
  42. Tulving E, Kapur S, Craik FI, Moscovitch M, Houle S. Hemispheric encoding/retrieval asymmetry in episodic memory: positron emission tomography findings. Proceedings of the National Academy of Sciences of the United States of America. 1994;91:2016–2020
  43. Wedig MM, Rauch SL, Albert MS, Wright CI. Differential amygdala habituation to neutral faces in young and elderly adults. Neuroscience Letters. 2005;385:114–119
  44. Whalen PJ, Shin LM, McInerney SC, Fischer H, Wright CI, Rauch SL. A functional MRI study of human amygdala responses to facial expressions of fear versus anger. Emotion. 2001;1:70–83
  45. Whittaker JF, Deakin JF, Tomenson B. Face processing in schizophrenia: defining the deficit. Psychololical Medicine. 2001;31:499–507
  46. Williams MA, Morris AP, McGlone F, Abbott DF, Mattingley JB. Amygdala responses to fearful and happy facial expressions under conditions of binocular suppression. Journal of Neuroscience. 2004;24:2898–2904
  47. Wright CI, Fischer H, Whalen PJ, McInerney SC, Shin LM, Rauch SL. Differential prefrontal cortex and amygdala habituation to repeatedly presented emotional stimuli. Neuroreport. 2001;12:379–383
  48. Wright CI, Martis B, Schwartz CE, Shin LM, Fischer HH, McMullin K, et al. Novelty responses and differential effects of order in the amygdala, substantia innominata, and inferior temporal cortex. Neuroimage. 2003;18:660–669
  49. Yang TT, Menon V, Eliez S, Blasey C, White CD, Reid AJ, et al. Amygdalar activation associated with positive and negative facial expressions. Neuroreport. 2002;13:1737–1741
  50. Zald DH, Prado JV. Emotion, olfaction, and the human amygdala: amygdala activation during aversive olfactory stimulation. Proceedings of the National Academy of Sciences of the United States of America. 1997;94:4119–4124
  51. Zald DH. The human amygdala and the emotional evaluation of sensory stimuli. Brain Research Reviews. 2003;41:88–123
  52. Zalla T, Koechlin E, Pietrini P, Basso G, Aquino P, Sirigu A, et al. Differential amygdala responses to winning and losing: a functional magnetic resonance imaging study in humans. European Journal of Neuroscience. 2000;12:1764–1770

PII: S0925-4927(08)00023-1

doi: 10.1016/j.pscychresns.2008.01.003

Psychiatry Research: Neuroimaging
Volume 171, Issue 3 , Pages 199-206 , 31 March 2009

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