Increased extent of object-selective cortex in schizophrenia

Wynn, Jonathan K.; Green, Michael F.; Engel, Stephen; Korb, Alex; Lee, Junghee; Glahn, David; Nuechterlein, Keith H.; Cohen, Mark S.

doi:10.1016/j.pscychresns.2008.01.005

« Previous Next »Psychiatry Research: Neuroimaging
Volume 164, Issue 2 , Pages 97-105, 30 November 2008

Increased extent of object-selective cortex in schizophrenia

Jonathan K. Wynn
- Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
- VA Greater Los Angeles Healthcare System; Los Angeles, CA, USA
- Corresponding author. VA Greater Los Angeles Healthcare System, MIRECC, Bldg. 210, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA. Tel.: +1 310 478 3711x44957; fax: +1 310 268 4056.
Michael F. Green
- Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
- VA Greater Los Angeles Healthcare System; Los Angeles, CA, USA
Stephen Engel
- Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA
Alex Korb
- Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
Junghee Lee
- Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
- VA Greater Los Angeles Healthcare System; Los Angeles, CA, USA
David Glahn
- Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Keith H. Nuechterlein
- Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
- Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA
Mark S. Cohen
- Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
- Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA

Received 25 May 2007; received in revised form 26 November 2007; accepted 8 January 2008.

Abstract

Schizophrenia patients exhibit deficits in various stages of visual information processing. Despite recent informative efforts to examine visual processing in schizophrenia with functional magnetic resonance imaging (fMRI), much remains unknown about the basic function, structure, and organization of key early visual processing areas in schizophrenia. This study examined magnitude and topography of regional brain activity in three early visual processing areas: early retinotopically organized areas (V1-V4), motion-sensitive areas (human area MT, hMT+), and object-recognition areas (lateral occipital complex, LO). Using visual stimuli that are known to preferentially activate each respective region, we compared responses in these areas in 22 schizophrenia patients and 19 normal controls. Activity in all three regions was of similar amplitude in schizophrenia patients and normal controls. Activity in retinotopically organized areas and hMT+ showed good spatial overlap between groups. However, activation of LO was more widely distributed in patients compared with normal controls. The findings of abnormal spatial organization of LO in schizophrenia patients may converge with behavioral evidence of deficits in schizophrenia patients for object-recognition tasks that are believed to be mediated by LO activity.

Keywords: Schizophrenia, visual processing, functional MRI, object processing