Psychiatry Research: Neuroimaging
Volume 164, Issue 1 , Pages 86-89, 30 October 2008

Medial temporal N-acetyl-aspartate in pediatric major depression

  • Frank P. MacMaster

      Affiliations

    • Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, USA
    • ,
  • Gregory J. Moore

      Affiliations

    • Departments of Psychiatry and Radiology, Penn State College of Medicine, Hershey, PA, 17033, USA
    • ,
  • Aileen Russell

      Affiliations

    • Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, USA
    • ,
  • Yousha Mirza

      Affiliations

    • Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, USA
    • ,
  • S. Preeya Taormina

      Affiliations

    • Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, USA
    • ,
  • Christian Buhagiar

      Affiliations

    • Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, USA
    • ,
  • David R. Rosenberg

      Affiliations

    • Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, USA
    • Department of Psychiatry, Children's Hospital of Michigan, Detroit, MI, 48201, USA
    • Corresponding Author InformationCorresponding author. Psychiatry 9B-UHC; 4201 St. Antoine Boulevard, Detroit, MI 48201, USA. Tel.: +1 313 577 9000; fax: +1 313 577 5900.

Received 27 August 2007; received in revised form 21 December 2007; accepted 22 December 2007.

Abstract 

The medial temporal cortex (MTC) has been implicated in the pathogenesis of pediatric major depressive disorder (MDD). Eleven MDD case-control pairs underwent proton magnetic resonance spectroscopic imaging. N-acetyl-aspartate was lower in the left MTC (27%) in MDD patients versus controls. Lower N-acetyl-aspartate concentrations in MDD patients may reflect reduced neuronal viability.

Keywords: Depression, Hippocampus, N-acetyl-aspartate

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PII: S0925-4927(08)00002-4

doi:10.1016/j.pscychresns.2007.12.022

Psychiatry Research: Neuroimaging
Volume 164, Issue 1 , Pages 86-89, 30 October 2008

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