Psychiatry Research: Neuroimaging
Volume 164, Issue 3 , Pages 237-244 , 30 December 2008

Pattern of brain atrophy in elderly patients with depression revealed by voxel-based morphometry

  • Karl Egger

      Affiliations

    • Department of Radiology, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Michael Schocke

      Affiliations

    • Department of Radiology, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Elisabeth Weiss

      Affiliations

    • Department of General Psychiatry, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Simone Auffinger

      Affiliations

    • Department of General Psychiatry, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Regina Esterhammer

      Affiliations

    • Department of Radiology, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Georg Goebel

      Affiliations

    • Department of Medical Statistics, Computer Sciences and Health Management, Medical University Innsbruck, Schöpfstraße 41/1, A-6020 Innsbruck, Austria
    • ,
  • Thomas Walch

      Affiliations

    • Department of General Psychiatry, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Sergei Mechtcheriakov

      Affiliations

    • Department of General Psychiatry, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
    • ,
  • Josef Marksteiner

      Affiliations

    • Department of Psychiatry and Psychotherapy, Landeskrankenhaus Klagenfurt, St. Veiter Strasse 47, A-9020 Klagenfurt, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +43 463 538 22970.

Received 7 May 2007 ,Revised 5 November 2007 ,Accepted 22 December 2007.

References 

  1. Alexopoulos GS, Meyers BS, Young RC, Mattis S, Kakuma T. The course of geriatric depression with reversible dementia: a controlled study. American Journal of Psychiatry. 1993;150:1693–1699
  2. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 4th ed.. Washington, DC: APA; 1994;
  3. Ashburner J, Friston KJ. Voxel-based morphometry — the methods. Neuroimage. 2000;11:805–821
  4. Ballmaier M, Toga AW, Blanton RE, Sowell ER, Lavretsky H, Peterson J, et al. Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. American Journal of Psychiatry. 2004;161:99–108
  5. Bell-McGinty S, Butters MA, Meltzer CC, Greer PJ, Reynolds CF, Becker JT. Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration. American Journal of Psychiatry. 2002;159:1424–1427
  6. Boone KB, Lesser I, Miller B, Wohl M, Berman N, Lee A, et al. Cognitive functioning in a mildly to moderately depressed geriatric sample: relationship to chronological age. Journal of Neuropsychiatry and Clinical Neurosciences. 1994;6:267–272
  7. Bremner JD, Vythilingam M, Vermetten E, Nazeer A, Adil J, Khan S, et al. Reduced volume of orbitofrontal cortex in major depression. Biological Psychiatry. 2002;51:273–279
  8. Brenneis C, Wenning GK, Egger KE, Schocke M, Trieb T, Seppi K, et al. Basal forebrain atrophy is a distinctive pattern in dementia with Lewy bodies. Neuroreport. 2004;15:1711–1714
  9. Butters MA, Whyte EM, Nebes RD, Begley AE, Dew MA, Mulsant BH, et al. The nature and determinants of neuropsychological functioning in late-life depression. Archives of General Psychiatry. 2004;61:587–595
  10. Campbell S, Marriott M, Nahmias C, MacQueen GM. Lower hippocampal volume in patients suffering from depression: a meta-analysis. American Journal of Psychiatry. 2004;161:598–607
  11. Cardinal RN, Parkinson JA, Hall J, Everitt BJ. Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neuroscience Biobehavioral Reviews. 2002;26:321–352
  12. Damasio H, Grabowski T, Frank R, Galaburda AM, Damasio AR. The return of Phineas Gage: clues about the brain from the skull of a famous patient. Science. 1994;264:1102–1105
  13. Drevets WC. Neuroimaging abnormalities in the amygdala in mood disorders. Annals of the New York Academy of Sciences. 2003;985:420–444
  14. Egger K, Mueller J, Schocke M, Brenneis C, Rinnerthaler M, Seppi K, et al. Voxel based morphometry reveals specific gray matter changes in primary dystonia. Movement Disorders. 2007;22:1538–1542
  15. Folstein MF, Folstein SE, McHugh PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research. 1975;12:189–198
  16. Frodl T, Meisenzahl E, Zetzsche T, Bottlender R, Born C, Groll C, et al. Enlargement of the amygdala in patients with a first episode of major depression. Biological Psychiatry. 2002;51:708–714
  17. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage. 2001;14:21–36
  18. Hoptman MJ, Gunning-Dixon FM, Murphy CF, Lim KO, Alexopoulos GS. Structural neuroimaging research methods in geriatric depression. American Journal of Geriatric Psychiatry. 2006;14:812–822
  19. Janssen J, Hulshoff Pol HE, de Leeuw FE, Schnack HG, Lampe IK, Kok RM, et al. Hippocampal volume and subcortical white matter lesions in late life depression: comparison of early and late onset depression. Journal of Neurology, Neurosurgery, and Psychiatry. 2007;78:638–640
  20. Jatzko A, Rothenhofer S, Schmitt A, Gaser C, Demirakca T, Weber-Fahr W, et al. Hippocampal volume in chronic posttraumatic stress disorder (PTSD): MRI study using two different evaluation methods. Journal of Affective Disorders. 2006;94:121–126
  21. Lidstone SC, Stoessl AJ. Understanding the placebo effect: contributions from neuroimaging. Molecular Imaging and Biology. 2007;9:176–185
  22. Lockwood KA, Alexopoulos GS, van Gorp WG. Executive dysfunction in geriatric depression. American Journal of Psychiatry. 2002;159:1119–1126
  23. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 2003;19:1233–1239
  24. Mandelli L, Serretti A, Zanardi R, Rossini D, De Ronchi D, Tarricone I, et al. Antidepressant response in the elderly. Psychiatry Research. 2007;152:37–44
  25. Mayberg HS, Brannan SK, Tekell JL, Silva JA, Mahurin RK, McGinnis S, et al. Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biological Psychiatry. 2000;48:830–843
  26. Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. American Journal of Psychiatry. 1999;156:675–682
  27. Mechtcheriakov S, Brenneis C, Egger K, Koppelstaetter F, Schocke M, Marksteiner J. A widespread distinct pattern of cerebral atrophy in patients with alcohol addiction revealed by voxel-based morphometry. Journal of Neurology, Neurosurgery, and Psychiatry. 2007;78:610–614
  28. Meeks TW, Ropacki SA, Jeste DV. The neurobiology of neuropsychiatric syndromes in dementia. Current Opinion in Psychiatry. 2006;19:581–586
  29. Mervaala E, Fohr J, Kononen M, Valkonen-Korhonen M, Vainio P, Partanen K, et al. Quantitative MRI of the hippocampus and amygdala in severe depression. Psychological Medicine. 2000;30:117–125
  30. Miller MD, Paradis CF, Houck PR, Mazumdar S, Stack JA, Rifai AH, et al. Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale. Psychiatry Research. 1992;41:237–248
  31. Oslin DW, Streim J, Katz IR, Edell WS, TenHave T. Change in disability follows inpatient treatment for late life depression. Journal of the American Geriatrics Society. 2000;48:357–362
  32. Rajkowska G. Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells. Biological Psychiatry. 2000;48:766–777
  33. Reitan RM. Validity of the trail making test as an indicator of organic brain damage. Perceptual and Motor Skills. 1958;8:271–276
  34. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. American Journal of Psychiatry. 1984;141:1356–1364
  35. Sheline YI, Gado MH, Price JL. Amygdala core nuclei volumes are decreased in recurrent major depression. Neuroreport. 1998;9:2023–2028
  36. Sheline YI, Sanghavi M, Mintun MA, Gado MH. Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. Journal of Neuroscience. 1999;19:5034–5043
  37. Small GW. Treatment of geriatric depression. Depression and Anxiety. 1998;1:32–42
  38. Spitzer RL, Williams JB, Gibbon M, First MB. The Structured Clinical Interview for DSM-III-R (SCID). I: history, rationale, and description. Archives of General Psychiatry. 1992;49:624–629
  39. Sunderland T, Hill JL, Mellow AM, Lawlor BA, Gundersheimer J, Newhouse PA, et al. Clock drawing in Alzheimer's disease. A novel measure of dementia severity. Journal of the American Geriatrics Society. 1989;37:725–729
  40. Taki Y, Kinomura S, Awata S, Inoue K, Sato K, Ito H, et al. Male elderly subthreshold depression patients have smaller volume of medial part of prefrontal cortex and precentral gyrus compared with age-matched normal subjects: a voxel-based morphometry. Journal of Affective Disorders. 2005;88:313–320
  41. Tang Y, Wang F, Xie G, Liu J, Li L, Su L, et al. Reduced ventral anterior cingulate and amygdala volumes in medication-naive females with major depressive disorder: a voxel-based morphometric magnetic resonance imaging study. Psychiatry Research. Neuroimaging. 2007;156:83–86
  42. Yaffe K, Blackwell T, Gore R, Sands L, Reus V, Browner WS. Depressive symptoms and cognitive decline in nondemented elderly women: a prospective study. Archives of General Psychiatry. 1999;56:425–430
  43. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, et al. Development and validation of a geriatric depression screening scale: a preliminary report. Journal of Psychiatric Research. 1982;17:37–49

PII: S0925-4927(07)00263-6

doi: 10.1016/j.pscychresns.2007.12.018

Psychiatry Research: Neuroimaging
Volume 164, Issue 3 , Pages 237-244 , 30 December 2008

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