Psychiatry Research: Neuroimaging
Volume 164, Issue 1 , Pages 73-76, 30 October 2008

The MAO-A genotype does not modulate resting brain metabolism in adults

  • Nelly Alia-Klein

      Affiliations

    • Medical Department, Brookhaven National Laboratory, Upton, New York, 11973, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 631 344 8104.
    • ,
  • Aarti Kriplani

      Affiliations

    • Medical Department, Brookhaven National Laboratory, Upton, New York, 11973, United States
    • ,
  • Kith Pradhan

      Affiliations

    • Medical Department, Brookhaven National Laboratory, Upton, New York, 11973, United States
    • ,
  • Jim Yeming Ma

      Affiliations

    • Medical Department, Brookhaven National Laboratory, Upton, New York, 11973, United States
    • ,
  • Jean Logan

      Affiliations

    • Medical Department, Brookhaven National Laboratory, Upton, New York, 11973, United States
    • ,
  • Benjamin Williams

      Affiliations

    • Kings College, London, SE5 8AF Department of Psychiatry, UK
    • ,
  • Ian W. Craig

      Affiliations

    • Kings College, London, SE5 8AF Department of Psychiatry, UK
    • ,
  • Frank Telang

      Affiliations

    • Medical Department, Brookhaven National Laboratory, Upton, New York, 11973, United States
    • ,
  • Dardo Tomasi

      Affiliations

    • Medical Department, Brookhaven National Laboratory, Upton, New York, 11973, United States
    • ,
  • Rita Z. Goldstein

      Affiliations

    • Medical Department, Brookhaven National Laboratory, Upton, New York, 11973, United States
    • ,
  • Gene-Jack Wang

      Affiliations

    • Medical Department, Brookhaven National Laboratory, Upton, New York, 11973, United States
    • Mount Sinai School of Medicine, New York, NY 10029, United States
    • ,
  • Nora D. Volkow

      Affiliations

    • National Institute on Drug Abuse, Bethesda MD 20892, United States
    • ,
  • Joanna S. Fowler

      Affiliations

    • Medical Department, Brookhaven National Laboratory, Upton, New York, 11973, United States
    • Mount Sinai School of Medicine, New York, NY 10029, United States

Received 23 July 2007; received in revised form 5 December 2007; accepted 22 December 2007.

Abstract 

Variation in the monoamine-oxidase-A (MAO-A) gene has been associated with volumetric changes in corticolimbic regions with differences in their response to relevant emotional tasks. Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype.

Keywords: MAO-A, FDG, Baseline

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PII: S0925-4927(07)00262-4

doi:10.1016/j.pscychresns.2007.12.010

Psychiatry Research: Neuroimaging
Volume 164, Issue 1 , Pages 73-76, 30 October 2008

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