Hippocampal volumes and depression subtypes

Greenberg, Daniel L.; Payne, Martha E.; MacFall, James R.; Steffens, David C.; Krishnan, Ranga R.

doi:10.1016/j.pscychresns.2007.12.009

« Previous Next »Psychiatry Research: Neuroimaging
Volume 163, Issue 2 , Pages 126-132, 15 July 2008

Hippocampal volumes and depression subtypes

Daniel L. Greenberg
- Psychology Research, VA Boston Healthcare System, Boston, MA, USA
- Corresponding author. Psychology Research (151-A), 150 South Huntington Avenue, Boston, MA 02130, USA. Tel.: +1 818 926 0421.
Martha E. Payne
- Psychiatry Department, Duke University Medical Center, Durham, NC, USA
- Neuropsychiatric Imaging Research Laboratory, Duke University Medical Center, Durham, NC, USA
James R. MacFall
- Radiology Department, Duke University Medical Center, Durham, NC, USA
- Neuropsychiatric Imaging Research Laboratory, Duke University Medical Center, Durham, NC, USA
David C. Steffens
- Psychiatry Department, Duke University Medical Center, Durham, NC, USA
Ranga R. Krishnan
- Psychiatry Department, Duke University Medical Center, Durham, NC, USA

Received 25 March 2007; received in revised form 25 September 2007; accepted 22 December 2007.

Abstract

Studies of depression and hippocampal volume have yielded inconsistent results. This inconsistency could stem from the heterogeneity of depressive disorders. We conducted cross-sectional and longitudinal analyses of hippocampal volumes in atypical depressive, melancholic depressive, and control subjects. We found no effect of depression subtype on hippocampal volume or memory performance.

Keywords: Depression, Hippocampus, Morphometry