Psychiatry Research: Neuroimaging
Volume 164, Issue 3 , Pages 185-197 , 30 December 2008

Atypical modulation of cognitive control by arousal in autism

  • Gabriel S. Dichter

      Affiliations

    • Department of Psychiatry and Neurodevelopmental Disorders Research Center, University of North Carolina at Chapel Hill School of Medicine, CB# 3366, 101 Manning Drive, Chapel Hill, NC 27599-7160, United States
    • Duke-UNC Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, 27710, United States
    • ,
  • Aysenil Belger

      Affiliations

    • Department of Psychiatry and Neurodevelopmental Disorders Research Center, University of North Carolina at Chapel Hill School of Medicine, CB# 3366, 101 Manning Drive, Chapel Hill, NC 27599-7160, United States
    • Duke-UNC Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, 27710, United States
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, University of North Carolina School of Medicine, CB# 7160, 101 Manning Drive, Chapel Hill, NC 27599-7160, United States.

Received 24 May 2007 ,Revised 27 September 2007 ,Accepted 18 December 2007.

References 

  1. American Psychiatric Association . Diagnostic and statistical manual of mental disorders: DSM-IV. 4th ed.. Washington, DC: American Psychiatric Association; 1994;
  2. Baron-Cohen S, Belmonte MK. Autism: a window onto the development of the social and the analytic brain. Annual Review of Neuroscience. 2005;28:109–126
  3. Baron-Cohen S, Ring HA, Wheelwright S, Bullmore ET, Brammer MJ, Simmons A, et al. Social intelligence in the normal and autistic brain: an fMRI study. European Journal of Neuroscience. 1999;11(6):1891–1898
  4. Belmonte MK, Yurgelun-Todd DA. Functional anatomy of impaired selective attention and compensatory processing in autism. Brain Research.. Cognitive Brain Research. 2003;17(3):651–664
  5. Bradshaw, J.L. (2001). Developmental disorders of the frontostriatal system: neuropsychological, neuropsychiatric, and evolutionary perspectives. East Sussex, Philadelphia, Pa.: Psychology Press Ltd.; Taylor & Francis Inc.
  6. Burack JA, Enns JT, Stauder JEA, Mottron L, Randolph B. Attention and autism: behavioral and electrophysiological evidence. In:  Cohen DJ,  Volkmar F editor. Handbook of Autism and Pervasive Developmental Disorders. 2nd ed.. New York: Wiley; 1997;p. 226–247
  7. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences. 2000;4(6):215–222
  8. Callejas A, Lupianez J, Funes MJ, Tudela P. Modulations among the alerting, orienting and executive control networks. Experimental Brain Research. 2005;167(1):27–37
  9. Castelli F, Frith C, Happe F, Frith U. Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain. 2002;125(Pt 8):1839–1849
  10. Ciesielski KT, Courchesne E, Elmasian R. Effects of focused selective attention tasks on event-related potentials in autistic and normal individuals. Electroencephalography and Clinical Neurophysiology. 1990;75(3):207–220
  11. Cohen RM, Semple WE, Gross M, Holcomb HJ, Dowling SM, Nordahl TE. Functional localization of sustained attention. Neuropsychiatry, Neuropsychology, and Behavioral Neurology. 1988;1:3–20
  12. Courchesne E, Lincoln AJ, Yeung-Courchesne R, Elmasian R, Grillon C. Pathophysiologic findings in nonretarded autism and receptive developmental language disorder. Journal of Autism and Developmental Disorders. 1989;19(1):1–17
  13. Dalton KM, Nacewicz BM, Johnstone T, Schaefer HS, Gernsbacher MA, Goldsmith HH, et al. Gaze fixation and the neural circuitry of face processing in autism. Nature Neuroscience. 2005;8(4):519–526
  14. Dichter GS, Belger A. Social stimuli interfere with cognitive control in autism. NeuroImage. 2007;35(3):1219–1230
  15. Dolcos F, Miller B, Kragel P, Jha A, McCarthy G. Regional brain differences in the effect of distraction during the delay interval of a working memory task. Brain Research. 2007;1152:171–181
  16. Fan J, Posner M. Human attentional networks. Psychiatry Prax. 2004;31(Suppl 2):S210–S214
  17. Fan J, McCandliss BD, Sommer T, Raz A, Posner MI. Testing the efficiency and independence of attentional networks. Journal of Cognitive Neuroscience. 2002;14(3):340–347
  18. Fan J, McCandliss BD, Fossella J, Flombaum JI, Posner MI. The activation of attentional networks. NeuroImage. 2005;26(2):471–479
  19. Frith U. Autism: Explaining the enigma. Oxford: Blackwell; 1989;
  20. Frith C, Done DJ. Stereotyped behavior in madness and in health. In:  Cooper SJ,  Dourish CT editor. Neurobiology of stereotyped behavior. Oxford: Clarendon Press; 1990;
  21. Genovese CR, Lazar NA, Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. NeuroImage. 2002;15(4):870–878
  22. Glover GH, Law CS. Spiral-in/out BOLD fMRI for increased SNR and reduced susceptibility artifacts. Magnetic Resonance in Medicine. 2001;46(3):515–522
  23. Goldstein G, Johnson CR, Minshew NJ. Attentional processes in autism. Journal of Autism and Developmental Disorders. 2001;31(4):433–440
  24. Gomot M, Bernard FA, Davis MH, Belmonte MK, Ashwin C, Bullmore ET, et al. Change detection in children with autism: an auditory event-related fMRI study. NeuroImage. 2006;29:475–484
  25. Happe F, Ehlers S, Fletcher P, Frith U, Johansson M, Gillberg C, et al. ‘Theory of mind’ in the brain. Evidence from a PET scan study of Asperger syndrome. NeuroReport. 1996;8(1):197–201
  26. Hill EL. Executive dysfunction in autism. Trends in Cognitive Sciences. 2004;8(1):26–32
  27. Hubl D, Bolte S, Feineis-Matthews S, Lanfermann H, Federspiel A, Strik W, et al. Functional imbalance of visual pathways indicates alternative face processing strategies in autism. Neurology. 2003;61(9):1232–1237
  28. Hughes C, Russell J, Robbins TW. Evidence for executive dysfunction in autism. Neuropsychologia. 1994;32(4):477–492
  29. Just MA, Cherkassky VL, Keller TA, Kana RK, Minshew NJ. Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry. Cerebral Cortex. 2007;17:951–961
  30. Kana RK, Keller TA, Minshew NJ, Just MA. Inhibitory control in high-functioning autism: decreased activation and underconnectivity in inhibition networks. Biological Psychiatry. 2007;62(3):198–206
  31. Kirino E, Belger A, Goldman-Rakic P, McCarthy G. Prefrontal activation evoked by infrequent target and novel stimuli in a visual target detection task: an event-related functional magnetic resonance imaging study. Journal of Neuroscience. 2000;20(17):6612–6618
  32. Lang, P.J., Bradley, M.M., Cuthbert, B.N. (1997). International Affective Picture System (IAPS): Technical manual and affective ratings.Unpublished manuscript.
  33. Lang PJ, Bradley MM, Cuthbert BN. Emotion, motivation, and anxiety: Brain mechanisms and psychophysiology. Biological Psychiatry. 1998;44(12):1248–1263
  34. Lang PJ, Bradley MM, Cuthbert BN. International Affective Picture System (IAPS): Instruction Manual and Affective Ratings, Technical Report A-4. Gainesville, Florida: The Center for Research in Psychophysiology; 1999;
  35. Lopez BR, Lincoln AJ, Ozonoff S, Lai Z. Examining the Relationship between Executive Functions and Restricted, Repetitive Symptoms of Autistic Disorder. Journal of Autism and Developmental Disorders. 2005;35(4):445–460
  36. Lord C, Rutter M, Le Couteur A. Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders. 1994;24:659–685
  37. Lord C, Risi S, Lambrecht L, Cook EH, Leventhal BL, DiLavore PC, et al. The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders. 2000;30(3):205–223
  38. MacDonald AW, Cohen JD, Stenger VA, Carter CS. Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science. 2000;288(5472):1835–1838
  39. McCarthy G, Luby M, Gore J, Goldman-Rakic P. Infrequent events transiently activate human prefrontal and parietal cortex as measured by functional MRI. Journal of Neurophysiology. 1997;77(3):1630–1634
  40. Minshew NJ, Goldstein G. The pattern of intact and impaired memory functions in autism. Journal of Child Psychology and Psychiatry. 2001;42(8):1095–1101
  41. Mottron L, Dawson M, Soulieres I, Hubert B, Burack J. Enhanced perceptual functioning in autism: an update, and eight principles of autistic perception. Journal of Autism and Developmental Disorders. 2006;36(1):27–43
  42. Ozonoff S, Pennington BF, Rogers SJ. Executive function deficits in high-functioning autistic individuals: relationship to theory of mind. Journal of Child Psychology and Psychiatry. 1991;32(7):1081–1105
  43. Pelphrey KA, Morris JP, McCarthy G. Neural basis of eye gaze processing deficits in autism. Brain. 2005;128(Pt 5):1038–1048
  44. Pierce K, Muller RA, Ambrose J, Allen G, Courchesne E. Face processing occurs outside the fusiform ‘face area’ in autism: evidence from functional MRI. Brain. 2001;124(Pt 10):2059–2073
  45. Plaisted K, O'Riordan M, Baron-Cohen S. Enhanced visual search for a conjunctive target in autism: a research note. Journal of Child Psychology and Psychiatry. 1998;39(5):777–783
  46. Posner MI. Attention: the mechanisms of consciousness. Proceedings of the National Academy of Sciences of the United States of America. 1994;91(16):7398–7403
  47. Ring HA, Baron-Cohen S, Wheelwright S, Williams SC, Brammer M, Andrew C, et al. Cerebral correlates of preserved cognitive skills in autism: a functional MRI study of embedded figures task performance. Brain. 1999;122(Pt 7):1305–1315
  48. Russell J. Autism as an executive disorder. Oxford: Oxford University Press; 1997;
  49. Sabatinelli D, Flaisch T, Bradley MM, Fitzsimmons JR, Lang PJ. Affective picture perception: gender differences in visual cortex?. NeuroReport. 2004;15(7):1109–1112
  50. Sabatinelli D, Bradley MM, Fitzsimmons JR, Lang PJ. Parallel amygdala and inferotemporal activation reflect emotional intensity and fear relevance. NeuroImage. 2005;24(4):1265–1270
  51. Schmitz N, Rubia K, Daly E, Smith A, Williams S, Murphy DG. Neural correlates of executive function in autistic spectrum disorders. Biological Psychiatry. 2006;59(1):7–16
  52. Schultz RT, Gauthier I, Klin A, Fulbright RK, Anderson AW, Volkmar F, et al. Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome. Archives of General Psychiatry. 2000;57(4):331–340
  53. Shafritz K, Dichter GS, Baranek G, Belger A. The neural circuitry mediating shifts in behavioral response and cognitive set in autism. Biological Psychiatry. 2008;63:974–980
  54. Shah A, Frith U. An islet of ability in autistic children: a research note. Journal of Child Psychology and Psychiatry. 1983;24(4):613–620
  55. Tager-Flusberg H. The conceptual basis for referential word meaning in children with autism. Child Development. 1985;56(5):1167–1178
  56. Tager-Flusberg H. Semantic processing in the free recall of autistic children: Further evidence of a cognitive deficit. British Journal of Developmental Psychology. 1991;9:417–430
  57. Turner M. Towards an Executive Dysfunction Account of Repetitive Behaviour in Autism. In:  Russell J editors. Autism as an executive disorder. Oxford: Oxford University Press; 1997;p. 57–100
  58. Turner M. Annotation: Repetitive behaviour in autism: a review of psychological research. Journal of Child Psychology and Psychiatry. 1999;40(6):839–849
  59. Webb SJ, Dawson G, Bernier R, Panagiotides H. ERP evidence of atypical face processing in young children with autism. Journal of Autism and Developmental Disorders. 2006;36(7):881–890
  60. Wechsler D. Wechsler Abbreviated Scale of Intelligence (WASI). San Antonio, TX: Harcourt Assessment; 1999;
  61. Williams JH, Waiter GD, Gilchrist A, Perrett DI, Murray AD, Whiten A. Neural mechanisms of imitation and 'mirror neuron' functioning in autistic spectrum disorder. Neuropsychologia. 2006;44(4):610–621
  62. Wing L, Gould J. Severe impairments of social interaction and associated abnormalities in children: epidemiology and classification. Journal of Autism and Developmental Disorders. 1979;9(1):11–29
  63. Yucel G, McCarthy G, Belger A. fMRI reveals that involuntary visual deviance processing is resource limited. NeuroImage. 2007;34(3):1245–1252

PII: S0925-4927(07)00252-1

doi: 10.1016/j.pscychresns.2007.12.005

Psychiatry Research: Neuroimaging
Volume 164, Issue 3 , Pages 185-197 , 30 December 2008

Article Tools

* Image Usage & Resolution