Psychiatry Research: Neuroimaging
Volume 164, Issue 2 , Pages 106-113 , 30 November 2008

Fronto-limbic circuitry in euthymic bipolar disorder: Evidence for prefrontal hyperactivation

  • Jennifer L. Robinson

      Affiliations

    • Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    • ,
  • E. Serap Monkul

      Affiliations

    • Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    • ,
  • Diana Tordesillas-Gutiérrez

      Affiliations

    • Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    • ,
  • Crystal Franklin

      Affiliations

    • Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    • ,
  • Carrie E. Bearden

      Affiliations

    • Departments of Psychiatry & Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior; University of California Los Angeles, CA, USA
    • ,
  • Peter T. Fox

      Affiliations

    • Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    • ,
  • David C. Glahn

      Affiliations

    • Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    • Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, The University of Texas Health Science Center at San Antonio, Mail Code 7792, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA. Tel.: +1 210 567 5508; fax: +1 210 567 1291.

Received 2 July 2007 ,Revised 4 October 2007 ,Accepted 18 December 2007.

References 

  1. Adler CM, Hollan SK, Schmithorst V, Tuchfarber MJ, Strakowski SM. Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task. Bipolar Disorders. 2004;6:540–549
  2. Altshuler L, Bookheimer S, Proenza MA, Townsend J, Sabb F, Firestine A, et al. Increased amygdala activation during mania: a functional magnetic resonance imaging study. American Journal of Psychiatry. 2005;162:1211–1213
  3. Altshuler LL, Bookheimer SY, Townsend J, Proenza MA, Eisenberger N, Sabb F. Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study. Biological Psychiatry. 2005;58:763–769
  4. Amaral DG, Price JL. Amygdalo-cortical projections in the monkey (Macaca fascicularis). The Journal of Comparative Neurology. 1984;230:465–496
  5. Barbas H, De Olmos J. Projections from the amygdala to basoventral and mediodorsal prefrontal regions in the rhesus monkey. The Journal of Comparative Neurology. 1990;300:549–571
  6. Baxter LR, Schwartz JM, Phelps ME, Mazziotta JC, Guze BH, Selin CE, et al. Reduction of prefrontal cortex glucose metabolism common to three types of depression. Archives of General Psychiatry. 1989;46:243–250
  7. Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, et al. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Archives of General Psychiatry. 2003;60:601–609
  8. First MG, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Non-Patient Edition. New York: Biometrics Research Department, New York State Psychiatric Institute; 1998;
  9. First MG, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Patient Edition. New York: Biometrics Research Department, New York State Psychiatric Institute; 1998;
  10. Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC. Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold. Magnetic Resonance in Medicine. 1995;33:636–647
  11. Friston KJ, Holmes AP, Worsley KJ. How many subjects constitute a study?. NeuroImage. 1999;10:1–5
  12. Ghashghaei HT, Barbas H. Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey. Neuroscience. 2002;115:1261–1279
  13. Hamilton M. A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry. 1960;23:56–62
  14. Hariri AR, Tessitore A, Mattay VS, Fera F, Weinberger DR. The amygdala response to emotional stimuli: a comparison of faces and scenes. NeuroImage. 2002;17(1):317–323
  15. Ketter TA, Kimbrell TA, George MS, Dunn RT, Speer AM, Benson BE, et al. Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder. Biological Psychiatry. 2001;49(2):97–109
  16. Krettek JE, Price JL. The cortical projections of the mediodorsal nucleus and adjacent thalamic nuclei in the rat. The Journal of Comparative Neurology. 1977;171:157–191
  17. Lane RD, Reiman EM, Ahern GL, Schwartz GE, Davidson RJ. Neuroanatomical correlates of happiness, sadness, and disgust. American Journal of Psychiatry. 1997;154:926–933
  18. Lane RD, Reiman EM, Bradley MM, Lang PJ, Ahern GL, Davidson RJ, et al. Neuroanatomical correlates of pleasant and unpleasant emotion. Neuropsychologia. 1997;35:1437–1444
  19. Lawrence NS, Williams AM, Surguladze S, Giampietro V, Brammer MJ, Andrew C, et al. Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biological Psychiatry. 2004;55:578–587
  20. Lieberman MD, Eisenberger NI, Crockett MJ, Tom SM, Pfeifer JH, Way BM. Putting feelings into words: affect labeling disrupts amygdala activity in response to affective stimuli. Psychological Science. 2007;18:421–428
  21. MacDonald AWI, Cohen JD, Stenger VA, Carter CS. Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science. 2000;288:1835–1838
  22. Malhi GS, Lagopoulos J, Sachdev PS, Ivanovski B, Shnier R. An emotional Stroop functional MRI study of euthymic bipolar disorder. Bipolar Disorders. 2005;7(Supplement 5):58
  23. Malhi GS, Ivanovski B, Hadzi-Pavlovic D, Mitchell PB, Vieta E, Sachdev P. Neuropsychological deficits and functional impairment in bipolar depression, hypomania and euthymia. Bipolar Disorders. 2007;9:114–125
  24. McDonald AJ. Organization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat. Neuroscience. 1991;44:1–14
  25. Phelps EA, Delgado MR, Nearing KI, LeDoux JE. Extinction learning in humans: role of the amygdala and vmPFC. Neuron. 2004;43:897–905
  26. Quirk GJ, Likhtik E, Pelletier JG, Pare D. Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons. Journal of Neuroscience. 2003;23:8800–8807
  27. Robbins TW. Shifting and stopping: fronto-striatal substrates, neurochemical modulation and clinical implications. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 2007;362:917–932
  28. Robinson LJ, Thompson JM, Gallagher P, Goswami U, Young AH, Ferrier IN. A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. Journal of Affective Disorders. 2006;93:105
  29. Rolls ET, Cowey A, Bruce V. Neurophysiological mechanisms underlying face processing within and beyond the temporal cortical visual areas. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 1992;335:11–21
  30. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, et al. Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage. 2004;23(Supplement 1):S208–S219
  31. Stein JL, Wiedholz LM, Bassett DS, Weinberger DR, Zink CF, Mattay VS, et al. A validated network of effective amygdala connectivity. NeuroImage. 2007;36:736–745
  32. Strakowski SM, Adler CM, Holland SK, Mills N, DelBello MP. A preliminary FMRI study of sustained attention in euthymic, unmedicated bipolar disorder. Neuropsychopharmacology. 2004;29:1734–1740
  33. Strakowski SM, Adler CM, Holland SK, Mills NP, DelBello MP, Eliassen JC. Abnormal fMRI brain activation in euthymic bipolar disorder patients during a counting Stroop interference task. American Journal of Psychiatry. 2005;162:1697–1705
  34. Strakowski SM, Delbello MP, Adler CM. The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Molecular Psychiatry. 2005;10:105–116
  35. Wessa M, Houenou J, Paillere-Martinot ML, Berthoz S, Artiges E, Leboyer M, et al. Fronto-striatal overactivation in euthymic bipolar patients during an emotional Go/NoGo task. American Journal of Psychiatry. 2007;164:638–646
  36. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. British Journal of Psychiatry. 1978;133(3):429–435
  37. Yurgelun-Todd DA, Gruber SA, Kanayama G, Killgore WD, Baird AA, Young AD. fMRI during affect discrimination in bipolar affective disorder. Bipolar Disorders. 2000;2(3):237–248(Part 2)

PII: S0925-4927(07)00250-8

doi: 10.1016/j.pscychresns.2007.12.004

Psychiatry Research: Neuroimaging
Volume 164, Issue 2 , Pages 106-113 , 30 November 2008

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