Psychiatry Research: Neuroimaging
Volume 162, Issue 2 , Pages 167-171 , 28 February 2008

Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosis

  • Roberto Roiz-Santiáñez

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain
    • ,
  • Benedicto Crespo-Facorro

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain
    • Corresponding Author InformationCorresponding author. Hospital Universitario Marqués de Valdecilla. Department of Psychiatry, Planta 2a, Edificio 2 de Noviembre. Avda. Valdecilla s/n, 39008, Santander. Spain. Tel.: +34 942 202537; fax: +34 942 203447.
    • ,
  • Rocío Pérez-Iglesias

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain
    • ,
  • José María Pelayo-Terán

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain
    • ,
  • Eugenio Carrasco-Marín

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Immunology, Santander, Spain
    • ,
  • Ignacio Mata

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain
    • ,
  • Elena Sánchez

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Neuroradiology, Santander, Spain
    • ,
  • Francisco Leyva-Cobián

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Immunology, Santander, Spain
    • ,
  • José Luis Vázquez-Barquero

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain

Received 18 April 2007 ,Revised 18 July 2007 ,Accepted 10 October 2007.

References 

  1. Andreasen NC. The Scale for the Assessment of Negative Symptoms (SANS). Iowa City: University of Iowa; 1983;
  2. Andreasen NC. The Scale for the Assessment of Positive Symptoms (SAPS). Iowa City: University of Iowa; 1984;
  3. Andreasen NC, Cohen G, Harris G, Cizadlo T, Parkkinen J, Rezai K, et al. Image processing for the study of brain structure and function: problems and programs. The Journal of Neuropsychiatry and Clinical Neurosciences. 1992;4:125–133
  4. Andreasen NC, Cizadlo T, Harris G, Swayze V, O'Leary DS, Cohen G, et al. Voxel processing techniques for the antemortem study of neuroanatomy and neuropathology using magnetic resonance imaging. The Journal of Neuropsychiatry and Clinical Neurosciences. 1993;5:121–130
  5. Andreasen NC, Rajarethinam R, Cizadlo T, Arndt S, Swayze VW, Flashman LA, et al. Automatic atlas-based volume estimation of human brain regions from MR images. Journal of Computer Assisted Tomography. 1996;20:98–106
  6. Callicott JH, Straub RE, Pezawas L, Egan MF, Mattay VS, Hariri AR, et al. Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 2005;102:8627–8632
  7. Cohen G, Andreasen NC, Alliger R, Arndt S, Kuan J, Yuh WT, et al. Segmentation techniques for the classification of brain tissue using magnetic resonance imaging. Psychiatry Research. Neuroimaging. 1992;45:33–51
  8. Crespo-Facorro B, Perez-Iglesias R, Ramirez-Bonilla M, Martinez-Garcia O, Llorca J, Luis Vazquez-Barquero J. A practical clinical trial comparing haloperidol, risperidone, and olanzapine for the acute treatment of first-episode nonaffective psychosis. The Journal of Clinical Psychiatry. 2006;67:1511–1521
  9. Crespo-Facorro B, Roiz-Santianez R, Pelayo-Teran JM, Gonzalez-Blanch C, Perez-Iglesias R, Gutierrez A, et al. Caudate nucleus volume and its clinical and cognitive correlations in first episode schizophrenia. Schizophrenia Research. 2007;91:87–96
  10. Danis VA, Millington M, Hyland VJ, Grennan D. Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism. Clinical and Experimental Immunology. 1995;99:303–310
  11. Hadjigeorgiou GM, Paterakis K, Dardiotis E, Dardioti M, Aggelakis K, Tasiou A, et al. IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury. Neurology. 2005;65:1077–1082
  12. Harris G, Andreasen NC, Cizadlo T, Bailey JM, Bockholt HJ, Magnotta VA, et al. Improving tissue classification in MRI: a three-dimensional multispectral discriminant analysis method with automated training class selection. Journal of Computer Assisted Tomography. 1999;23:144–154
  13. Katila H, Hanninen K, Hurme M. Polymorphisms of the interleukin-1 gene complex in schizophrenia. Molecular Psychiatry. 1999;4:179–181
  14. Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia. American Journal of Human Genetics. 2003;73:34–48
  15. Magnotta VA, Harris G, Andreasen NC, O'Leary DS, Yuh WT, Heckel D. Structural MR image processing using the BRAINS2 toolbox. Computerized Medical Imaging and Graphics. 2002;26:251–264
  16. Mata I, Crespo-Facorro B, Perez-Iglesias R, Carrasco-Marin E, Arranz MJ, Pelayo-Teran JM, et al. Association between the interleukin-1 receptor antagonist gene and negative symptom improvement during antipsychotic treatment. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 2006;141:939–943
  17. Meyer-Lindenberg, A., Nichols, T., Callicott, J.H., Ding, J., Kolachana, B., Buckholtz, J., Mattay, V. S., Egan, M., Weinberger, D.R., 2006. Impact of complex genetic variation in COMT on human brain function. Molecular Psychiatry 11, 867–877, 797.
  18. Papiol S, Molina V, Desco M, Rosa A, Reig S, Gispert JD, et al. Ventricular enlargement in schizophrenia is associated with a genetic polymorphism at the interleukin-1 receptor antagonist gene. NeuroImage. 2005;27:1002–1006
  19. Schrijver HM, van As J, Crusius JB, Dijkstra CD, Uitdehaag BM. Interleukin (IL)-1 gene polymorphisms: relevance of disease severity associated alleles with IL-1beta and IL-1ra production in multiple sclerosis. Mediators of Inflammation. 2003;12:89–94
  20. Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Archives of General Psychiatry. 2003;60:1187–1192
  21. Tarlow JK, Blakemore AI, Lennard A, Solari R, Hughes HN, Steinkasserer A, et al. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Human Genetics. 1993;9:403–404

PII: S0925-4927(07)00197-7

doi: 10.1016/j.pscychresns.2007.10.001

Psychiatry Research: Neuroimaging
Volume 162, Issue 2 , Pages 167-171 , 28 February 2008

Article Tools