Psychiatry Research: Neuroimaging
Volume 162, Issue 2 , Pages 167-171, 28 February 2008

Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosis

  • Roberto Roiz-Santiáñez

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain
    • ,
  • Benedicto Crespo-Facorro

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain
    • Corresponding Author InformationCorresponding author. Hospital Universitario Marqués de Valdecilla. Department of Psychiatry, Planta 2a, Edificio 2 de Noviembre. Avda. Valdecilla s/n, 39008, Santander. Spain. Tel.: +34 942 202537; fax: +34 942 203447.
    • ,
  • Rocío Pérez-Iglesias

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain
    • ,
  • José María Pelayo-Terán

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain
    • ,
  • Eugenio Carrasco-Marín

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Immunology, Santander, Spain
    • ,
  • Ignacio Mata

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain
    • ,
  • Elena Sánchez

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Neuroradiology, Santander, Spain
    • ,
  • Francisco Leyva-Cobián

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Immunology, Santander, Spain
    • ,
  • José Luis Vázquez-Barquero

      Affiliations

    • University Hospital Marqués de Valdecilla, Department of Psychiatry. School of Medicine, University of Cantabria., Santander, Spain

Received 18 April 2007; received in revised form 18 July 2007; accepted 10 October 2007.

Abstract 

Studies of schizophrenia that combine imaging and genetic approaches attempt to map structural brain anomalies associated with genetic risk variants. The aim of the present study was to investigate whether variations in the interleukin-1 receptor antagonist (IL-1RN) were associated with structural brain characteristics of 73 minimally medicated first-episode non-affective psychotic patients. We did not find evidence for association between genetic variation in the IL-1RN gene and brain morphometry at early phases of the illness.

Keywords: Structural neuroimaging, MRI, Brain morphometry, Schizophrenia, Gene, Interleukin-1 receptor antagonist genotype

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PII: S0925-4927(07)00197-7

doi:10.1016/j.pscychresns.2007.10.001

Psychiatry Research: Neuroimaging
Volume 162, Issue 2 , Pages 167-171, 28 February 2008

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