Psychiatry Research: Neuroimaging
Volume 163, Issue 1 , Pages 84-94 , 30 May 2008

Age-dependent reduction of amygdala volume in bipolar disorder

  • Tracy J. Doty

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    • Center for Cognitive Neuroscience, Duke University Medical Center, Durham, NC 27710, USA
    • ,
  • Martha E. Payne

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    • ,
  • David C. Steffens

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    • ,
  • John L. Beyer

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    • ,
  • K. Ranga R. Krishnan

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    • ,
  • Kevin S. LaBar

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    • Center for Cognitive Neuroscience, Duke University Medical Center, Durham, NC 27710, USA
    • Corresponding Author InformationCorresponding author. Center for Cognitive Neuroscience, Duke University Box 90999, Durham, NC 27708-0999, USA. Tel.: +1 919 681 0664; fax: +1 919 681 0815.

Received 10 August 2006 ,Revised 17 May 2007 ,Accepted 9 August 2007.

References 

  1. Altshuler LL, Bartzokis G, Grieder T, Curran J, Mintz J. Amygdala enlargement in bipolar disorder and hippocampal reduction in Schizophrenia: an MRI study demonstrating neuroanatomic specificity. Archives of General Psychiatry. 1998;55:663–664
  2. Altshuler LL, Bartzokis G, Grieder T, Curran J, Jimenez T, Leight K, et al. An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biological Psychiatry. 2000;48:147–162
  3. Altshuler L, Bookheimer S, Proenza MA, Townsend J, Sabb F, Firestine A, et al. Increased amygdala activation during mania: a function magnetic resonance imaging study. American Journal of Psychiatry. 2005;162:1211–1213
  4. Baldassano CF, Marangell LB, Gyulai L, Ghaemi SN, Joffe H, Kim DR, et al. Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BP participants. Bipolar Disorders. 2005;7:465–470
  5. Bartzokis G, Altshuler LL, Greider T, Curran J, Keen B, Dixon WJ. Reliability of medial temporal lobe volume measurements using reformatted 3D images. Psychiatry Research: Neuroimaging Section. 1998;82:11–24
  6. Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JZ, Gore JC, et al. Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry. 2003;60:1201–1208
  7. Blumberg HP, Donegan NH, Sanislow CA, Collins S, Lacadie C, Skudlarski P, et al. Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder. Psychopharmacology. 2005;183(3):308–313
  8. Bowley MP, Drevets WC, Ongur D, Price JL. Low glial numbers in the amygdala in major depressive disorder. Biological Psychiatry. 2002;52:404–412
  9. Brambilla P, Harenski K, Nicoletti M, Sassi RB, Mallinger AG, Frank E, et al. MRI investigation of temporal lobe structures in bipolar patients. Journal of Psychiatric Research. 2003;37:287–295
  10. Brierley B, Shaw P, David AS. The human amygdala: a systematic review and meta-analysis of volumetric magnetic resonance imaging. Brain Research Reviews. 2002;39:84–105
  11. Campbell S, MacQueen G. An update on regional brain volume differences associated with mood disorders. Current Opinion in Psychiatry. 2006;19:25–33
  12. Cervantes P, Gelber S, Kin FN, Nair VN, Schwartz G. Circadian secretion of cortisol in bipolar disorder. Journal of Psychiatry & Neuroscience. 2001;26(5):411–416
  13. Chang K, Karchemskiy A, Barnea-Goraly N, Garrett A, Simeonova DI, Reiss A. Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 2005;44(6):565–573
  14. Chen BK, Sassi R, Axelson D, Hatch JP, Sanches M, Nicoletti M, et al. Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder. Biological Psychiatry. 2004;56:399–405
  15. Convit A, McHugh P, Wolf OT, de Leon MJ, Bobinski M, De Santi S. MRI volume of the amygdala: a reliable method allowing separation from the hippocampal formation. Psychiatry Research: Neuroimaging. 1999;90:113–123
  16. Davidson RJ, Lewis DA, Alloy LB, Amaral DG, Bush G, Cohen JD, et al. Neural and behavioral substrates of mood and mood regulation. Biological Psychiatry. 2002;52:478–502
  17. DelBello MP, Zimmerman ME, Mills NP, Getz GE, Strakowski SM. Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disorders. 2004;6:43–52
  18. Drevets WC. Neuroimaging abnormalities in the amygdala in mood disorders. Annals of the New York Academy of Sciences. 2003;985:420–444
  19. Duvernoy HM. The Human Brain: Surface, Three-dimensional Surface Anatomy and MRI. New York: Springer-Verlag; 1991;
  20. Frazier JA, Chiu S, Breeze JL, Makris N, Lange N, Kennedy DN, et al. Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. American Journal of Psychiatry. 2005;162:1256–1265
  21. Fu CH, Williams SC, Cleare AJ, Brammer MJ, Walsh ND, Kim J, et al. Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. Archives of General Psychiatry. 2004;61(9):877–889
  22. Holsboer F, von Bardeleben U, Wiedemann K, Müller OA, Stalla GK. Serial assessment of corticotropin-releasing hormone response after dexamethasone in depression: implications for pathophysiology of DST nonsuppression. Biological Psychiatry. 1987;22:228–234
  23. Lawrence NS, Williams AM, Surguladze S, Giampietro V, Brammer MJ, Andrew C, et al. Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biological Psychiatry. 2004;55(6):578–587
  24. Lupien SJ, de Leon M, de Santi S, Convit A, Tarshish C, Thakur M, et al. Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nature Neuroscience. 1998;1(1):69–73
  25. MacFall JR, Byrum CE, Parashos I, Early B, Charles HC, Chittilla V, et al. Relative accuracy and reproducibility of regional MRI brain volumes for point-counting methods. Psychiatry Research: Neuroimaging. 1994;55(3):167–177
  26. Manji HK, Moore GJ, Chen G. Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic–depressive illness. Biological Psychiatry. 2000;48:740–754
  27. Mayberg HS. Limbic–cortical dysregulation: a proposed model of depression. Journal of Neuropsychiatry and Clinical Neurosciences. 1997;9(3):471–481
  28. McEwen BS. Possible mechanisms for atrophy of the human hippocampus. Molecular Psychiatry. 1997;2(3):255–262
  29. Payne ME, Fetzer DL, MacFall JR, Provenzale JM, Byrum CE, Krishnan KRR. Development of a semi-automated method for quantification of MRI gray and white matter lesions in geriatric subjects. Psychiatry Research: Neuroimaging. 2002;115(1–2):63–77
  30. Pearlson GD, Barta PE, Powers RE, Menon RR, Richards SS, Aylward EH, et al. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biological Psychiatry. 1997;41:1–14
  31. Posse S, Fitzgerald D, Gao K, Habel U, Rosenberg D, Moore GJ, et al. Real-time fMRI of temporolimbic regions detects amygdala activation during single-trial self-induced sadness. Neuroimage. 2003;18(3):760–768
  32. Rainnie DG, Bergeron R, Sajdyk TJ, Patil M, Gehlert DR, Shekhar A. Corticotrophin releasing factor-induced synaptic plasticity in the amygdala translates stress into emotional disorders. Journal of Neuroscience. 2004;24:3471–3479
  33. Rodriguez Manzanares PA, Isoardi NA, Carrer HF, Molina VA. Previous stress facilitates fear memory, attenuates GABAergic inhibition, and increases synaptic plasticity in the rat basolateral amygdala. Journal of Neuroscience. 2005;25:8725–8734
  34. Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW. Hippocampal atrophy in recurrent major depression. Proceedings of the National Academy of Sciences of the United States of America. 1996;93:3908–3913
  35. Sheline YI, Barch DM, Donnelly JM, Ollinger JM, Snyder AZ, Mintun MA. Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biological Psychiatry. 2001;50:651–658
  36. Starkman MN, Giordani B, Gebarski SS, Berent S, Schork MA, Schteingart DE. Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing's Disease. Biological Psychiatry. 1999;46:1595–1602
  37. Strakowski SM, DelBello MP, Sax KW, Zimmerman ME, Shear PK, Hawkins JM, et al. Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Archives of General Psychiatry. 1999;56(3):254–260
  38. Swayze VW, Andreasen NC, Alliger RJ, Yuh WTC, Ehrhardt JC. Subcortical and temporal structures in affective disorder and schizophrenia: a magnetic resonance imaging study. Biological Psychiatry. 1992;31:221–240
  39. Tebartz van Elst L, Bäumer D, Ebert D, Trimble MR. Chronic antidopaminergic medication might affect amygdala structure in patients with schizophrenia. Pharmacopsychiatry. 2004;37:217–220
  40. Vyas A, Mitra R, Shankaranarayana R, Chattarji S. Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. Journal of Neuroscience. 2002;22:6810–6818
  41. Wang L, LaBar KS, McCarthy G. Mood alters amygdala activation to sad distractors during an attentional task. Biological Psychiatry. 2006;60:1139–1146
  42. Yurgelun-Todd DA, Gruber SA, Kanayama G, Killgore WD, Baird AA, Young AD. fMRI during affect discrimination in bipolar affective disorder. Bipolar Disorders. 2000;2:237–248

PII: S0925-4927(07)00155-2

doi: 10.1016/j.pscychresns.2007.08.003

Psychiatry Research: Neuroimaging
Volume 163, Issue 1 , Pages 84-94 , 30 May 2008

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