Psychiatry Research: Neuroimaging
Volume 156, Issue 3 , Pages 247-250, 15 December 2007

Serotonin-1A receptors in frontotemporal dementia compared with controls

  • Krista L. Lanctôt

      Affiliations

    • Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    • Corresponding Author InformationCorresponding author. 2075 Bayview Avenue Toronto, ON M4N 3M5. Tel.: +1 416 480 6100; fax: +1 416 480 6022.
    • ,
  • Nathan Herrmann

      Affiliations

    • Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    • ,
  • Hooman Ganjavi

      Affiliations

    • Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    • ,
  • Sandra E. Black

      Affiliations

    • Department of Neurology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    • ,
  • Pablo M. Rusjan

      Affiliations

    • Vivian M. Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    • ,
  • Sylvain Houle

      Affiliations

    • Vivian M. Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    • ,
  • Alan A. Wilson

      Affiliations

    • Vivian M. Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

Received 9 July 2007; accepted 17 July 2007.

Abstract 

Using PET neuroimaging, we demonstrated that four frontotemporal lobar dementia (FTLD) patients had significantly decreased serotonin 5-HT1A binding potential (BP) compared with controls in all 10 brain regions examined. These pilot data suggest that profound 5-HT1A BP losses may be present and contribute to symptomatology and treatment response in FTLD.

Keywords: Serotonergic system, Binding potential, PET imaging

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PII: S0925-4927(07)00149-7

doi:10.1016/j.pscychresns.2007.07.003

Psychiatry Research: Neuroimaging
Volume 156, Issue 3 , Pages 247-250, 15 December 2007

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