Psychiatry Research: Neuroimaging
Volume 162, Issue 3 , Pages 214-220 , 15 April 2008

123I-ADAM SPECT imaging of serotonin transporter binding in patients with Night Eating Syndrome: A preliminary report

  • Jennifer D. Lundgren

      Affiliations

    • Center for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    • Currently at the Department of Psychology, University of Missouri-Kansas City, Kansas City, MO, USA.
    • ,
  • Andrew B. Newberg

      Affiliations

    • Department of Radiology, Division of Nuclear Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    • ,
  • Kelly C. Allison

      Affiliations

    • Center for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    • ,
  • Nancy A. Wintering

      Affiliations

    • Department of Radiology, Division of Nuclear Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    • ,
  • Karl Ploessl

      Affiliations

    • Department of Radiology, Division of Nuclear Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    • ,
  • Albert J. Stunkard

      Affiliations

    • Center for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    • Corresponding Author InformationCorresponding author: 3535 Market Street, Ste. 3025, Philadelphia, PA 19104-3309, USA. Tel.: +1 215 898 7413; fax: +1 215 898 2878.

Received 25 October 2006 ,Revised 3 July 2007 ,Accepted 16 July 2007.

References 

  1. Acton PD, Choi S-R, Hou C, Ploessl K, Kung H. Quantification of serotonin transporters in nonhuman primates using 123I-ADAM and SPECT. Journal of Nuclear Medicine. 2001;42:1556–1562
  2. Allison KC, Grilo CM, Masheb RM, Stunkard AJ. Binge eating disorder and night eating syndrome: a comparative study of disordered eating. Journal of Consulting and Clinical Psychology. 2005;73:1107–1115
  3. Allison KC, Lundgren JD, O'Reardon JP, Martino NS, Sarwer DB, Wadden TA, et al. The Night Eating Questionnaire (NEQ): psychometric properties of a measure of severity of the night eating syndrome. Eating Behaviors. 2008;9:62–72
  4. Beck AT. The Beck Depression Inventory. San Antonio: Harcourt Brace; 1996;
  5. Catafau AM, Perez V, Plaza P, Pascual JC, Bullich S, Suarez M, et al. Serotonin transporter occupancy induced by paroxetine in patients with major depression disorder: a 123I-ADAM SPECT study. Psychopharmacology. 2006;189:145–153
  6. Catafau AM, Pérez V, Penengo M, Bullich S, Danús M, Puigdemont D, et al. SPECT of serotonin transporters using the 123I-ADAM: optimal imaging time after bolus injection and long-term test–retest in health volunteers. Journal of Nuclear Medicine. 2005;46:1301–1309
  7. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders—Patient Ed. (SCID-I/P with Psychotic Screen, Version 2.0). New York State Psychiatric Institute: Biometrics Research Department; 1996;
  8. Herold N, Uebelhack K, Franke L, Amthauer H, Luedemann L, Bruhn H, et al. Imaging of serotonin transporters and its blockade by citalopram inpatients with major depression using a novel SPECT ligand [123I]-ADAM. Journal of Neural Transmission. 2006;113:659–670
  9. Ichimiya T, Suhara T, Sudo Y, Okubo Y, Nakayama K, Nankai M, et al. Serotonin transporter binding in patients with mood disorders: a PET study with [11c](+)McN5652. Biological Psychiatry. 2002;51:715–722
  10. Jacobsen LK, Staley JK, Malison RT, Zoghbi SS, Seibyl JP, Kosten TR, et al. Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients. American Journal of Psychiatry. 2000;157:1134–1140
  11. Klein N, Sacher J, Geiss-Granadia T, Attarbaschi T, Mossaheb N, Lanzenberger R, et al. In vivo imaging of serotonin transporter occupancy by means of SPECT and [123I]ADAM in healthy subjects administered different doses of escitalopram or citalopram. Psychopharmacology. 2006;188:263–272
  12. Kuikka JT, Tammela L, Karhunen L, Rissanen A, Bergström KA, Naukkarinen H, et al. Reduced serotonin transporter binding in binge eating women. Psychopharmacology. 2001;155:310–314
  13. Lin KJ, Liu CY, Wey SP, Hsiao IT, Wu J, Fu YK, et al. Brain SPECT imaging and whole-body biodistribution with [(123)I]ADAM— a serotonin transporter radiotracer in healthy human subjects. Nuclear Medicine and Biology. 2006;33:193–202
  14. Lundgren JD, Allison KC, Crow S, O'Reardon JP, Berg KC, Galbraith J, et al. Prevalence of the night eating syndrome in a psychiatric population. American Journal of Psychiatry. 2006;163:156–158
  15. Malison RT, Price LH, Berman R, van Dyck CH, Pelton GH, Carpenter L, et al. Reduced brain serotonin transporter availability in major depression and measured by [123I]-2β-carbomethoxy-3β-(4-iodephenyl) tropane and single photon emission computed tomography. Biological Psychiatry. 1998;44:1090–1098
  16. Mash DC, Staley JK, Izenwasser S, Basile M, Ruttenber AJ. Serotonin transporters upregulate with chronic cocaine use. Journal of Chemical Neuroanatomy. 2000;20:271–280
  17. Meyer JH, Houle S, Sagrati S, Carella A, Hussey DF, Ginovart N, et al. Brain serotonin transporter binding potential measured with carbon 11-labelled DASB positron emission tomography. Archives of General Psychiatry. 2004;61:1271–1279
  18. Miyaoka T, Yasukawa R, Tsubouchi K, Miura S, Shimizu Y, Sukegawa T, et al. Successful treatment of nocturnal eating/drinking syndrome with selective serotonin reuptake inhibitors. International Clinical Psychopharmacology. 2003;18:175–177
  19. Newberg AB, Amsterdam JD, Wintering N, Ploessl K, Swanson RL, Shults J, et al. 123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study. Journal of Nuclear Medicine. 2005;46:973–977
  20. O'Reardon JP, Ringel BL, Dinges DF, Allison KC, Rogers NL, Martino NS, et al. Circadian eating and sleeping patterns in the night eating syndrome. Obesity Research. 2004;12:1789–1796
  21. O'Reardon JP, Stunkard AJ, Allison KC. Clinical trial of sertraline in the treatment of night eating syndrome. International Journal of Eating Disorders. 2004;35:16–26
  22. O'Reardon JP, Allison KC, Martino NS, Lundgren JD, Heo M, Stunkard AJ. A randomized placebo-controlled trial of sertraline in the treatment of the night eating syndrome. American Journal of Psychiatry. 2006;163:893–898
  23. Pogarell O, Hamann C, Pöpperl G, Juckel G, Choukèr M, Zaudig M, et al. Elevated brain serotonin transporter availability in patients with obsessive–compulsive disorder. Biological Psychiatry. 2003;54:1406–1413
  24. Resnick SM, Karp JS, Turetsky BI, Gur RE. Comparison of anatomically defined versus physiologically based regional localization: effects on PET–FDG quantitation. Journal of Nuclear Medicine. 1993;34:201–208
  25. Stengler-Wenzke K, Müller U, Angermeyer MC, Sabri O, Hesse S. Reduced serotonin transporter availability in obsessive–compulsive disorder (OCD). European Archives of Psychiatry and Clinical Neuroscience. 2004;254:252–255
  26. Stockmeier CA. Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. Journal of Psychiatric Research. 2003;37:357–373
  27. Stunkard AJ, Grace WJ, Wolff HG. The night-eating syndrome: a pattern of food intake among certain obese patients. American Journal of Medicine. 1955;9:78–86
  28. Stunkard AJ, Allison KC, Lundgren JD, Martino NS, Heo M, Etemad B, et al. A paradigm for facilitating pharmacotherapy research at a distance: treatment of the night eating syndrome. Journal of Clinical Psychiatry. 2006;67:1568–1572
  29. Tauscher J, Pirker W, Willeit M, deZwaan M, Bailer U, Neumeister A, et al. [123I]-β-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa. Biological Psychiatry. 2001;49:326–332
  30. Tolmunen T, Joensuu M, Saarinen PI, Mussalo H, Ahola P, Vanninen R, et al. Elevated midbrain serotonin transporter availability in mixed mania: a case report. BMC Psychiatry. 2004;4:27
  31. Vaswani M, Linda FK, Ramish S. Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review. Progress in Neuro-psychopharmacology & Biological Psychiatry. 2003;27:85–102
  32. Willeit M, Praschak-Rieder N, Neumeister A, Pirker W, Asenbaum S, Vitouch O, et al. [123I]-β-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug-free depressed patients with seasonal affective disorder. Biological Psychiatry. 2000;47:482–489

PII: S0925-4927(07)00147-3

doi: 10.1016/j.pscychresns.2007.07.006

Psychiatry Research: Neuroimaging
Volume 162, Issue 3 , Pages 214-220 , 15 April 2008

Article Tools

* Image Usage & Resolution