Psychiatry Research: Neuroimaging
Volume 156, Issue 3 , Pages 185-197 , 15 December 2007

Hippocampus and amygdala volumes in a random community-based sample of 60–64 year olds and their relationship to cognition

  • Jerome J. Maller

      Affiliations

    • Centre for Mental Health Research, The Australian National University, Canberra, Australia
    • Corresponding Author InformationCorresponding author. Centre for Mental Health Research, Building 63, Eggleston Road, Australian National University, Acton ACT 0200, Australia. Tel.: +61 2 6125 1030; fax: +61 2 6125 0733.
    • ,
  • Kaarin J. Anstey

      Affiliations

    • Centre for Mental Health Research, The Australian National University, Canberra, Australia
    • ,
  • Chantal Réglade-Meslin

      Affiliations

    • Centre for Mental Health Research, The Australian National University, Canberra, Australia
    • ,
  • Helen Christensen

      Affiliations

    • Centre for Mental Health Research, The Australian National University, Canberra, Australia
    • ,
  • Wei Wen

      Affiliations

    • School of Psychiatry, University of New South Wales, and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
    • ,
  • Perminder Sachdev

      Affiliations

    • School of Psychiatry, University of New South Wales, and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia

Received 5 May 2005 ,Revised 8 December 2005 ,Accepted 21 June 2007.

References 

  1. Aartsen MJ, Martin M, Zimprich D. Gender differences in level and change in cognitive functioning. Gerontology. 2004;50:35–38
  2. Abe K. Modulation of hippocampal long-term potentiation by the amygdala: a synaptic mechanism linking emotion and memory. Japanese Journal of Pharmacology. 2001;86:18–22
  3. Anstey KJ, Maller JJ. The role of volumetric MRI in understanding mild cognitive impairment and similar classifications. Aging and Mental Health. 2003;7:238–250
  4. Anstey KJ, Maller JJ, Meslin C, Christensen H, Jorm AF, Wen W, et al. Hippocampal and amygdalar volumes in relation to handedness in adults aged 60–64. Neuroreport. 2004;15:2825–2829
  5. Atchley WR, Gaskins CT, Anderson D. Statistical properties of ratios. I. Empirical results. Systematic Zoology. 1976;25:137–148
  6. Baddeley A, Emslie H, Nimmo-Smith I. The Spot-the-Word Test. Bury St Edmunds (England): Thames Valley Test Company; 1992;
  7. Basso M, Yang J, Warren L, MacAvoy MG, Varma P, Bronen RA, et al. Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease. Psychiatry Research. 2006;146:251–261
  8. Bartres-Faz D, Junque C, Clemente IC, Serra-Grabulosa JM, Guardi J, Lopez-Alomar A, et al. MRI and genetic correlates of cognitive function in elders with memory impairment. Neurobiology of Aging. 2001;22:449–459
  9. Bilir E, Craven W, Hugg J, Gilliam F, Martin R, Faught E, et al. Volumetric MRI of the limbic system: anatomic determinants. Neuroradiology. 1998;40:138–144
  10. Bobinski M, Wegiel J, Wisniewski HM, Tarnawski M, Reisberg B, Mlodzik B, et al. Atrophy of hippocampal formation subdivisions correlates with stage and duration of Alzheimer disease. Dementia. 1995;6:205–210
  11. Braak, H., Braak, E., 1997. Staging of Alzheimer-related cortical destruction. International Psychogeriatrics 9 (Suppl. 1), 257-261; Discussion 269-272.
  12. Brewer JB, Moghekar A. Imaging the medial temporal lobe: exploring new dimensions. Trends in Cognitive Sciences. 2002;6:217–223
  13. Brierly B, Shaw P, David AS. The human amygdala: a systematic review and meta-analysis of volumetric magnetic resonance imaging. Brain Research Brain. 2002;39:84–105
  14. Cahill L, Haier RJ, Fallon J, Alkire MT, Tang C, Keator D, et al. Amygdala activity at encoding correlated with long-term, free-recall of emotional information. Proceedings of the National Academy of Sciences of the United States of America. 1996;93:8016–8021
  15. Chantome M, Perruchet P, Hasboun D, Dormont D, Sahel M, Sourour N, et al. Is there a negative correlation between explicit memory and hippocampal volume?. NeuroImage. 1999;10:589–595
  16. Convit A, McHugh P, Wolf OT, de Leon MJ, Bobinski M, De Santi S, et al. MRI volume of the amygdala: a reliable method allowing separation from the hippocampal formation. Psychiatry Research: Neuroimaging. 1999;90:113–123
  17. Convit A, de Asis J, de Leon MJ, Tarshish CY, De Santi S, Rusinek H. Atrophy of the medial occipitotemporal, inferior, and middle temporal gyri in non-demented elderly predict decline to Alzheimer's disease. Neurobiology of Aging. 2000;21:19–26
  18. Convit A, Wolf OT, Tarshish C, de Leon MJ. Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. Proceedings of the National Academy of Sciences of the United States of America. 2003;100:2019–2022
  19. DeCarli C. Mild cognitive impairment: prevalence, prognosis, aetiology, and treatment. Lancet Neurology. 2003;2:15–21
  20. Delis DC, Kramer JH, Kaplan E, Ober BA. California Verbal Learning Test. San Antonio: Psychological Corporation, Harcourt Brace Jovanovich; 1987;
  21. den Heijer T, Oudkerk M, Launer LJ, van Duijn CM, Hofman A, Breteler MM. Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes. Neurology. 2002;59:746–748
  22. Duchesne S, Pruessner J, Collins DL. Appearance-based segmentation of medial temporal lobe structures. Neuroimage. 2002;17:515–531
  23. Duvernoy HM. The Human Brain. 2nd edition. New York: Springer; 1999;
  24. Filipek PA, Richelme C, Kennedy DN, Caviness VS. The young adult human brain: an MRI-based morphometric analysis. Cerebral Cortex. 1994;4:344–360
  25. Folstein MF, Folstein SE, McHugh PR. Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research. 1975;12:189–198
  26. Garcia R. Stress, synaptic plasticity, and psychopathology. Reviews in the Neurosciences. 2002;13:195–208
  27. Giedd JN, Vaituzis AC, Hamburger SD, Lange N, Rajapakse JC, Kaysen D, et al. Quantitative MRI of the temporal lobe, amygdala, and hippocampus in normal human development: ages 4–18 years. Journal of Comparative Neurology. 1996;366:223–230
  28. Goldman WP, Morris JC. Evidence that age-associated memory impairment is not a normal variant of aging. Alzheimer Disease and Associated Disorders. 2001;15:72–79
  29. Goldberg D, Bridges K, Duncan-Jones P, Grayson D. Detecting anxiety and depression in general medical settings. British Medical Journal. 1988;297:897–899
  30. Goldstein JM, Seidman LJ, Horton NJ, Makris N, Kennedy DN, Caviness VS, et al. Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cerebral Cortex. 2001;11:490–497
  31. Golebiowski M, Barcikowska M, Pfeffer A. Magnetic resonance imaging-based hippocampal volumetry in patients with dementia of the Alzheimer type. Dementia and Geriatric Cognitive Disorders. 1999;10:284–288
  32. Gur RC, Gunning-Dixon F, Bilker WB, Gur RE. Sex differences in temporo-limbic and frontal brain volumes of healthy adults. Cerebral Cortex. 2002;12:998–1003
  33. Hackert VH, den Heijer T, Oudkerk M, Koudstaal PJ, Hofman A, Breteler MM. Hippocampal head size associated with verbal memory performance in nondemented elderly. Neuroimage. 2002;17:1365–1372
  34. Jack CR. MRI-based hippocampal volume measurements in epilepsy. Epilepsia. 1994;35:S21–S29
  35. Jenkins R, Fox NC, Rossor AM, Harvey R, Rossor MN. Intracranial volume and Alzheimer disease. Archives in Neurology. 2000;57:220–224
  36. Kobayashi S, Okada K, Koide H, Bokura H, Yamaguchi S. Subcortical silent brain infarction as a risk factor for clinical stroke. Stroke. 1997;28:1932–1939
  37. Kramer JH, Delis DC, Daniel M. Sex differences in verbal learning. Journal of Clinical Psychology. 1998;44:907–915
  38. Krasuski JS, Alexander GE, Horwitz B, Daly EM, Murphy DG, Rapoport SI, et al. Volumes of medial temporal lobe structures in patients with Alzheimer's disease and mild cognitive impairment (and in healthy controls). Biological Psychiatry. 1998;43:60–68
  39. Laakso MP. Structural imaging in cognitive impairment and the dementias: an update. Current Opinion in Neurology. 2002;15:415–421
  40. Laakso MP, Juottonen K, Partanen K, Vainio P, Soininen H. MRI volumetry of the hippocampus: the effect of slice thickness on volume formation. Magnetic Resonance Imaging. 1997;15:263–265
  41. Lange N, Giedd JN, Castellanos FX, Vaituzis AC, Rapoport JL. Variability of human brain structure size: ages 4–20 years. Psychiatry Research: Neuroimaging. 1997;74:1–12
  42. Larrabee GJ, Crook TC. Do men show more rapid age-associated decline in simulated everyday verbal memory than do women?. Psychology and Aging. 1993;8:68–71
  43. Luft AR, Skalej M, Welte D, Kolb R, Klose U. Reliability and exactness of MRI-based volumetry: a phantom study. Journal of Magnetic Resonance Imaging. 1996;6:700–704
  44. Lye TC, Piguet O, Grayson DA, Creasey H, Ridley LR, Bennett HP, et al. Hippocampal size and memory function in the ninth and tenth decades of life: the Sydney Older Persons Study. Journal of Neurology, Neurosurgery and Psychiatry. 2004;75:548–554
  45. Mackay CE, Roberts N, Mayes AR, Downes JJ, Foster JK, Mann D. An exploratory study of the relationship between face recognition memory and the volume of medial temporal lobe structures in healthy young males. Behavioral Neurology. 1998;11:3–20
  46. MacLullich AMJ, Ferguson KJ, Deary LJ, Seckl JR, Starr JM, Wardlaw JM. Intracranial capacity and brain volumes are associated with cognition in healthy elderly men. Neurology,. 2002;59:169–174
  47. Maller, J.J., Anstey, K.J., Jorm, A.F., Christensen, H., Meslin, C., Wen, W., Sachdev, P., submitted for publication. Association between intracranial volume, cognition and education in a community sample of 60 to 64 year olds. Neuropsychology.
  48. Mega MS, Small GW, Xu ML, Felix J, Manese M, Tran NP, et al. Hippocampal atrophy in persons with age-associated memory impairment: volumetry within a common space. Psychosomatic Medicine. 2002;64:487–492
  49. Montaldi D, Mayes AR, Barnes A, Hadley DM, Patterson J, Wyper DJ. Effects of level of retrieval success on recall-related frontal and medial temporal lobe activations. Behavioural Neurology. 2002;13:123–131
  50. Nelson MD, Saykin AJ, Flashman LA, Riordan HJ. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Archives of General Psychiatry. 1998;55:433–440
  51. Pedraza O, Bowers D, Gilmore R. Asymmetry of the hippocampus and amygdala in MRI volumetric measurements of normal adults. Journal of the International Neuropsychological Society. 2004;10:664–678
  52. Phelps EA, Anderson AK. Emotional memory: what does the amygdala do?. Current Biology. 1997;7:R311–R314
  53. Preston AR, Gabrieli JDE. Different functions for different medial temporal lobe structures?. Learning and Memory. 2002;9:215–217
  54. Pruessner JC, Li LM, Serles W, Pruessner M, Collins DL, Kabani N, et al. Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories. Cerebral Cortex. 2000;10:433–442
  55. Raz N, Gunning FM, Head D, Dupuis JH, McQuain J, Briggs SD, et al. Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. Cerebral Cortex. 1997;7:268–282
  56. Reber PJ, Siwiec RM, Gitleman DR, Parrish TB, Mesulam MM, Paller K. Neural correlates of successful encoding identified using functional magnetic resonance imaging. Journal of Neuroscience. 2002;22:9541–9548
  57. Reber PJ, Wong EC, Buxton RB. Encoding activity in the medial temporal lobe examined with anatomically constrained fMRI analysis. Hippocampus. 2002;12:363–376
  58. Reynolds MD, Johnston JM, Dodge HH, DeKosky ST, Ganguli M. Small head size is related to low Mini-Mental State Examination scores in a community sample of nondemented older adults. Neurology. 1999;53:228–229
  59. Rubin EH, Storandt M, Miller JP, Kinscherf DA, Grant EA, Morris JC, et al. A prospective study of cognitive function and onset of dementia in cognitively healthy elders. Archives of Neurology. 1998;55:395–401
  60. Sachdev P, Parslow R, Salonikas C, Lux O, Wen W, Maller JJ, et al. Homocysteine and the brain in midadult life: evidence for an increased risk of leukoaraiosis in men. Archives of Neurology. 2004;61:1369–1376
  61. Seab JP, Jagust WJ, Wong ST, Roos MS, Reed BR, Budinger TF. Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease. Magnetic Resonance in Medicine. 1988;8:200–208
  62. Shastri L. Episodic memory and cortico-hippocampal interactions. Trends in Cognitive Sciences. 2002;6:162–168
  63. Shrout P, Fleiss JL. Intraclass correlation: uses in assessing rater reliability. Psychological Bulletin. 1979;86:420–428
  64. Smith A. Symbol Digit Modalities Test (SDMT) Manual. Los Angeles: Western Psychological Services; 1982;
  65. Squire LR. Memory systems of the brain: a brief history and current perspective. Neurobiology of Learning and Memory. 2004;82:171–177
  66. Statistical Package for the Social Sciences. SPSS Inc, Chicago, IL.
  67. Statistical Parametric Modelling. Wellcome, UK. http://www.fil.ion.ucl.ac.uk/spm/spm99.html
  68. Strange BA, Fletcher PC, Henson RNA, Friston KJ, Dolan RJ. Segregating the functions of the human hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 1999;96:4034–4039
  69. Sullivan EV, Marsh L, Mathalon DH, Lim KO, Pfefferbaum A. Age-related decline in MRI volumes of temporal lobe gray matter but not hippocampus. Neurobiology of Aging. 1995;16:591–606
  70. Thoenissen D, Zilles K, Toni I. Differential involvement of parietal and precentral regions in movement preparation and motor intention. Journal of Neuroscience. 2002;22:9024–9034
  71. Unverzagt FW, Gao S, Baiyewu O, Ogunniyi AO, Gureje O, Perkins A, et al. Neurology. 2001;57:1655–1662
  72. van Petten C. Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: review and meta-analysis. Neuropsychologia. 2004;42:1313–1345
  73. van Petten C, Plante E, Davidson PSR, Kuo TY, Bajuscak L, Glisky EL. Memory and executive function in older adults: relationships with temporal and prefrontal gray matter volumes and white matter hyperintensities. Neuropsychologia. 2004;42:1313–1335
  74. Watson C, Jack CR, Cendes F. Volumetric magnetic resonance imaging. Clinical applications and contributions to the understanding of temporal lobe epilepsy. Archives of Neurology. 1997;54:1521–1531
  75. Wechsler D. A standardized memory scale for clinical use. Journal of Psychology. 1945;19:87–95
  76. Wen W, Sachdev PS. Extent and distribution of white matter hyperintensities in stroke patients: the Sydney Stroke Study. Stroke. 2004;35:2813–2819
  77. Wilson RS, Beckett LA, Bennett DA, Albert MS, Evans DA. Change in cognitive function in older persons from a community population: relation to age and Alzheimer disease. Archives of Neurology. 1999;56:1274–1279
  78. Xu J, Kobayashi S, Yamaguchi S, Iijima K, Okada K, Yamashita K. Gender effects on age-related changes in brain structure. American Journal of Neuroradiology. 2000;21:112–118
  79. Yurgekun-Todd DA, Killgore WDS, Cintron CB. Cognitive correlates of medial temporal lobe development across adolescence: a magnetic resonance imaging study. Perceptual and Motor Skills. 2003;96:3–17

PII: S0925-4927(07)00144-8

doi: 10.1016/j.pscychresns.2007.06.005

Psychiatry Research: Neuroimaging
Volume 156, Issue 3 , Pages 185-197 , 15 December 2007

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