Psychiatry Research: Neuroimaging
Volume 156, Issue 3 , Pages 257-261 , 15 December 2007

Pituitary volume in teenagers with first-presentation borderline personality disorder

  • Belinda Garner

      Affiliations

    • ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
  • ,
  • Andrew M. Chanen

      Affiliations

    • ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    • ORYGEN Youth Health, Northwestern Mental Health, Melbourne, Australia
    • Corresponding Author InformationCorresponding author. ORYGEN Research Centre, Locked Bag 10, Parkville, Victoria 3052, Australia. Tel.: +61 3 9342 2800; fax: +61 3 9387 3003.
  • ,
  • Lisa Phillips

      Affiliations

    • School of Behavioural Sciences, The University of Melbourne, Melbourne, Australia
  • ,
  • Dennis Velakoulis

      Affiliations

    • Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, and Melbourne Health, Melbourne, Australia
  • ,
  • Stephen J. Wood

      Affiliations

    • Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, and Melbourne Health, Melbourne, Australia
    • Brain Research Institute, Austin and Repatriation Medical Centre, Melbourne, Australia
  • ,
  • Henry J. Jackson

      Affiliations

    • ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    • School of Behavioural Sciences, The University of Melbourne, Melbourne, Australia
  • ,
  • Christos Pantelis

      Affiliations

    • Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, and Melbourne Health, Melbourne, Australia
  • ,
  • Patrick D. McGorry

      Affiliations

    • ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    • ORYGEN Youth Health, Northwestern Mental Health, Melbourne, Australia

Received 16 January 2007 ,Revised 30 March 2007 ,Accepted 2 May 2007.

References 

  1. Axelson DA, Doraiswamy PM, Boyko OB, Rodrigo Escalona P, McDonald WM, Ritchie JC, et al. In vivo assessment of pituitary volume with magnetic resonance imaging and systematic stereology: relationship to dexamethasone suppression test results in patients. Psychiatry Research. 1992;44:63–70
  2. Baxter L, Edell W, Gerner R, Fairbanks L, Gwirtsman H. Dexamethasone suppression test and axis I diagnoses of inpatients with DSM-III borderline personality disorder. Journal of Clinical Psychiatry. 1984;45:150–153
  3. Carrasco JL, Diaz-Marsa M, Ignacio Pastrana J, Molina R, Brotons L, Horcajadas C. Enhanced suppression of cortisol after dexamethasone in borderline personality disorder. A pilot study. Actas Espanolas de Psiquiatria: Acepsi. 2003;31:138–141
  4. Chanen AM, Jovev M, Jackson HJ. Adaptive functioning and psychiatric symptoms in adolescents with borderline personality disorder. Journal of Clinical Psychiatry. 2007;68:297–306
  5. De la Fuente JM, Mendlewicz J. TRH stimulation and dexamethasone suppression in borderline personality disorder. Biological Psychiatry. 1996;40:412–418
  6. De la Fuente JM, Bobes J, Vizuete C, Mendlewicz J. Biological nature of depressive symptoms in borderline personality disorder: endocrine comparison to recurrent brief and major depression. Journal of Psychiatric Research. 2002;36:137–145
  7. Dilsaver SC, Greden JF. The DST in borderline patients. American Journal of Psychiatry. 1983;140:1540–1541
  8. Doraiswamy PM, Krishnan KR, Figiel GS, Husain MM, Boyko OB, Rockwell WJ, et al. A brain magnetic resonance imaging study of pituitary gland morphology in anorexia nervosa and bulimia. Biological Psychiatry. 1990;28:110–116
  9. First MB, Gibbon M, Spitzer RL, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders — Patient Version (SCID-I/p). New York: Biometrics Research Department, New York State Psychiatric Institute; 1996;
  10. First MB, Gibbon M, Spitzer RL, Williams JBW, Benjamin LS. User's Guide for the Structured Clinical Interview for DSM-IV Axis II Personality Disorders. Washington, DC: American Psychiatric Press; 1997;
  11. Garner B, Pariante CM, Wood SJ, Velakoulis D, Phillips L, Soulsby B, et al. Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosis. Biological Psychiatry. 2005;58:417–423
  12. Gertz BJ, Contreras LN, McComb DJ, Kovacs K, Tyrrell JB, Dallman MF. Chronic administration of corticotropin-releasing factor increases pituitary corticotroph number. Endocrinology. 1987;120:381–388
  13. Grossman R, Yehuda R, New A, Schmeidler J, Silverman J, Mitropoulou V, et al. Dexamethasone suppression test findings in subjects with personality disorders: associations with posttraumatic stress disorder and major depression. American Journal of Psychiatry. 2003;160:1291–1298
  14. Heim C, Nemeroff CB. Neurobiology of early life stress: clinical studies. Seminars in Clinical Neuropsychiatry. 2002;7:147–159
  15. Kontaxakis V, Markianos M, Vaslamatzis G, Markidis M, Kanellos P, Stefanis C. Multiple neuroendocrinological responses in borderline personality disorder patients. Acta Psychiatrica Scandinavica. 1987;76:593–597
  16. Krishnan KR, Doraiswamy PM, Lurie SN, Figiel GS, Husain MM, Boyko OB, et al. Pituitary size in depression. Journal of Clinical Endocrinology and Metabolism. 1991;72:256–259
  17. Lahmeyer HW, Val E, Gaviria FM, Prasad RB, Pandey GN, Rodgers P, et al. EEG sleep, lithium transport, dexamethasone suppression, monoamine oxidase activity in borderline personality disorder. Psychiatry Research. 1988;25:19–30
  18. Lange W, Wulff H, Berea C, Beblo T, Saavedra AS, Mensebach C, et al. Dexamethasone suppression test in borderline personality disorder—effects of posttraumatic stress disorder. Psychoneuroendocrinology. 2005;30:919–923
  19. Lieb K, Rexhausen JE, Kahl KG, Schweiger U, Philipsen A, Hellhammer DH, et al. Increased diurnal salivary cortisol in women with borderline personality disorder. Journal of Psychiatric Research. 2004;38:559
  20. Macmaster FP, Russell A, Mirza Y, Keshavan MS, Banerjee SP, Bhandari R, et al. Pituitary volume in pediatric obsessive-compulsive disorder. Biological Psychiatry. 2006;59:252–257
  21. Macmaster FP, Russell A, Mirza Y, Keshavan MS, Taormina SP, Bhandari R, et al. Pituitary volume in treatment-naive pediatric major depressive disorder. Biological Psychiatry. 2006;60:862–866
  22. Pariante CM, Vassilopoulou K, Velakoulis D, Phillips L, Soulsby B, Wood SJ, et al. Pituitary volume in psychosis. British Journal of Psychiatry. 2004;185:5–10
  23. Rinne T, De Kloet E, Wouters L, Goekoop JG, DeRijk RH, van den Brink W. Hyperresponsiveness of hypothalamic–pituitary–adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse. Biological Psychiatry. 2002;52:1102–1112
  24. Sanchez MM, Ladd CO, Plotsky PM. Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models. Development and Psychopathology. 2001;13:419–449
  25. Sassi RB, Nicoletti M, Brambilla P, Harenski K, Mallinger AG, Frank E, et al. Decreased pituitary volume in patients with bipolar disorder. Biological Psychiatry. 2001;50:271–280
  26. Soloff PH, George A, Nathan RS. The dexamethasone suppression test in patients with borderline personality disorders. American Journal of Psychiatry. 1982;139:1621–1623
  27. Velakoulis D, Wood SJ, Wong MT, McGorry PD, Yung A, Phillips L, et al. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, ultra-high-risk individuals. Archives of General Psychiatry. 2006;63:139–149
  28. Westlund KN, Aguilera G, Childs GV. Quantification of morphological changes in pituitary corticotropes produced by in vivo corticotropin-releasing factor stimulation and adrenalectomy. Endocrinology. 1985;116:439–445
  29. Zanarini MC, Frankenburg FR, Dubo ED, Sickel AE, Trikha A, Levin A, et al. Axis I comorbidity of borderline personality disorder. American Journal of Psychiatry. 1998;155:1733–1739

PII: S0925-4927(07)00102-3

doi: 10.1016/j.pscychresns.2007.05.001

Psychiatry Research: Neuroimaging
Volume 156, Issue 3 , Pages 257-261 , 15 December 2007