A case of anorexia nervosa with Marchiafava–Bignami Disease that responded to high-dose intravenous corticosteroid administration

Tao, Hiroki; Kitagawa, Nobuki; Kako, Yuki; Yamanaka, Hiroyoshi; Ito, Koichi; Denda, Kenzo; Koyama, Tsukasa

doi:10.1016/j.pscychresns.2007.04.013

« Previous Next »Psychiatry Research: Neuroimaging
Volume 156, Issue 2 , Pages 181-184, 15 November 2007

A case of anorexia nervosa with Marchiafava–Bignami Disease that responded to high-dose intravenous corticosteroid administration

Department of Neuropsychiatry, Hokkaido University School of Medicine, Kita 14 Nishi 5, Kitaku, Sapporo, Hokkaido, Japan

Received 15 August 2005; received in revised form 23 January 2007; accepted 23 April 2007.

Abstract

We report the first known case of anorexia nervosa (AN) with Marchiafava–Bignami Disease (MBD) that responded to high-dose intravenous corticosteroid administration. A 16-year-old Japanese female with AN was diagnosed with MBD after rapid weight loss. During the acute stage, she suffered from a sudden onset of coma. After regaining consciousness, she presented with lack of movement, apathy, labile affect, and poverty of speech. On admission, magnetic resonance imaging showed an area of demyelination in the splenium of the corpus callosum. Positron emission tomography obtained 7 days after admission showed areas of hypoperfusion in the medial temporal lobe and in regions anterior and posterior to the central sulcus.

Keywords: Marchiafava-Bignami disease, High-dose intravenous corticosteroid administration, Splenium of corpus callosum