Psychiatry Research: Neuroimaging
Volume 156, Issue 2 , Pages 175-179 , 15 November 2007

Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: A pilot investigation comparing treatment responders and non-responders

  • Mona A. Mohamed

      Affiliations

    • The Johns Hopkins University School of Medicine, Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD, United States
    • FM Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States
    • ,
  • Mari A. Smith

      Affiliations

    • The Johns Hopkins University School of Medicine, Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD, United States
    • FM Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States
    • ,
  • Michael W. Schlund

      Affiliations

    • Department of Behavioral Psychology, Kennedy Krieger Institute, Baltimore, MD, United States
    • The Johns Hopkins University School of Medicine, Department of Psychiatry, 600 N. Wolfe St., Meyer 117, Baltimore, MD 21287, United States
    • Tel.: +1 410 955 6111; fax: +1 410 614 5913.
    • ,
  • Gerald Nestadt

      Affiliations

    • The Johns Hopkins University School of Medicine, Department of Psychiatry, 600 N. Wolfe St., Meyer 117, Baltimore, MD 21287, United States
    • Tel.: +1 410 955 6111; fax: +1 410 614 5913.
    • ,
  • Peter B. Barker

      Affiliations

    • The Johns Hopkins University School of Medicine, Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD, United States
    • FM Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States
    • ,
  • Rudolf Hoehn-Saric

      Affiliations

    • The Johns Hopkins University School of Medicine, Department of Psychiatry, 600 N. Wolfe St., Meyer 117, Baltimore, MD 21287, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 410 955 6111; fax: +1 410 614 5913.

Received 30 March 2007 ,Accepted 7 April 2007.

References 

  1. Barker PB. N-acetyl aspartate—a neuronal marker?. Annals of Neurology. 2001;49:423–424
  2. Bollini P, Pampallona S, Tibaldi G, Kupelnick B, Munizza C. Effectiveness of antidepressants. British Journal of Psychiatry. 1999;174:297–303
  3. Duyn JH, Gillen J, Sobering PC, Van Zijl PCM, Moonen CT. Multisection proton MR spectroscopic imaging of the brain. Radiology. 1993;188:277–282
  4. Gillard J, Waldman A, Barker P. Clinical MR Neuroimaging: Diffusion, Perfusion and Spectroscopy. Cambridge, England: Cambridge University Press; 2005;
  5. Golay X, Gillen J, Van Zijl PCM, Barker PB. Scan time reduction in proton magnetic resonance spectroscopic imaging of the human brain. Magnetic Resonance in Medicine. 2002;47:384–387
  6. Greenberg BD, George MS, Martin JD, Benjamin J, Schlaepfer TE, Altemus M, et al. Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive–compulsive disorder a preliminary study. American Journal of Psychiatry. 1997;154:867–869
  7. Hoehn-Saric R, McLeod DR, Zimmerli WD. Somatic manifestations in women with generalized anxiety disorder. Archives of General Psychiatry. 1989;46:1113–1119
  8. Kent JM, Rauch SL. Neuroimaging studies of anxiety disorders. In:  Charney DS,  Nestler EJ editor. Neurobiology of Mental Illness. New York: Oxford University Press; 2004;p. 639–660
  9. Lippitz B, Mindus P, Meyerson BA, Kihlstrom L, Lindquist C. Obsessive compulsive disorder and the right hemisphere: topographic analysis of lesions after anterior capsulotomy performed with thermocoagulation. Acta Neurochirurgica. 1997;68:61–63(Suppl)
  10. Pigott TA, Seay S. Pharmacotherapy of obsessive compulsive disorder. International Review of Psychiatry. 1997;9:133–147
  11. Rosenberg DR, MacMaster FP, Keshavan MS, Fitzgerald KD, Stewart RNC, Moore GJ. Decrease in caudate glutamate concentrations in pediatric obsessive–compulsive disorder patients taking paroxetine. Journal of the American Academy of Child and Adolescent Psychiatry. 2000;39:1096–1103
  12. Rosenberg DR, Amponsah A, Sullivan A, MacMillan S, Moore GJ. Increased medial thalamic choline in pediatric obsessive–compulsive disorder as detected by quantitative in vivo spectroscopic imaging. Journal of Child Neurology. 2001;16:636–641
  13. Saxena S, Rauch SL. Functional neuroimaging and the neuroanatomy of obsessive–compulsive disorder. Psychiatric Clinics of North America. 2000;23:563–586
  14. Smith EA, Russell A, Lorch E, Banerjee SP, Rose M, Ivey J, et al. Increased medial thalamic choline found in pediatric patients with obsessive–compulsive disorder versus major depression or healthy control subjects: a magnetic resonance spectroscopy study. Biological Psychiatry. 2003;54:1399–1405
  15. Soher BJ, Van Zijl PCM, Duyn JH, Barker PB. Quantitative proton spectroscopic imaging of the human brain. Magnetic Resonance in Medicine. 1996;35:356–363
  16. Sonawalla SB, Renshaw PF, Moore CM, Alpert JE, Nierenberg AA, Rosenbaum JF, et al. Compounds containing cytosolic choline in the basal ganglia: a potential biological marker of true drug response to fluoxetine. American Journal of Psychiatry. 1999;156:1638–1640

PII: S0925-4927(07)00091-1

doi: 10.1016/j.pscychresns.2007.04.002

Psychiatry Research: Neuroimaging
Volume 156, Issue 2 , Pages 175-179 , 15 November 2007

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