Psychiatry Research: Neuroimaging
Volume 162, Issue 1 , Pages 39-49 , 15 January 2008

Childhood adversity predicts earlier onset of major depression but not reduced hippocampal volume

  • Shannon N. Lenze

      Affiliations

    • Department of Psychology, University of Pittsburgh, 3rd Floor Sennott Square, Pittsburgh, PA 15260, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 412 624 4500; fax: +1 412 624 4428.
    • ,
  • Chengjie Xiong

      Affiliations

    • Department of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA
    • ,
  • Yvette I. Sheline

      Affiliations

    • Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

Received 5 April 2007 ,Accepted 7 April 2007.

References 

  1. Aboitiz F, Scheibel AB, Fisher RS, Zaidel E. Individual differences in brain asymmetries and fiber composition in the human corpus callosum. Brain Research. 1992;598:154–161
  2. Andreasen NC, Flashman L, Flaum M, Arndt S, Swayze V, O'Leary DS, et al. Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. Journal of the American Medical Association. 1994;272:1763–1769
  3. Bartzokis G, Mintz J, Marx P, Osborn D, Gutkind D, Chiang F, et al. Reliability of in vivo volume measures of hippocampus and other brain structures using MRI. Magnetic Resonance Imaging. 1993;11:993–1006
  4. Bernet CZ, Stein MB. Relationship of childhood maltreatment to the onset and course of major depression in adulthood. Depression and Anxiety. 1999;9:169–174
  5. Bifulco A, Brown GW, Harris TO. Childhood Experience of Care and Abuse (CECA): a retrospective interview measure. Journal of Child Psychology and Psychiatry. 1994;55:1419–1435
  6. Bifulco A, Brown GW, Lillie A, Jarvis J. Memories of childhood neglect and abuse: corroboration in a series of sisters. Journal of Child Psychology and Psychiatry. 1997;38:365–374
  7. Bifulco A, Brown GW, Moran P, Ball C, Campbell C. Predicting depression in women: the role of past and present vulnerability. Psychological Medicine. 1998;28:39–50
  8. Brambilla P, Soloff PH, Sala M, Nicoletti MA, Keshavan MS, Soares JC. Anatomical MRI study of borderline personality disorder patients. Psychiatry Research: Neuroimaging. 2004;131:125–133
  9. Bremner JD, Randall P, Vermetten E, Staib L, Bronen RA, Mazure C, et al. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse — a preliminary report. Biological Psychiatry. 1997;41:23–32
  10. Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Nazeer A, et al. MRI and PET study deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. American Journal of Psychiatry. 2003;160:924–932
  11. Brewin CR, Andrews B, Gotlib IH. Psychopathology and early experience: a reappraisal of retrospective reports. Psychological Bulletin. 1993;113:82–98
  12. Briere J, Runtz M. Symptomatology associated with childhood sexual victimization in a non-clinical adult sample. Child Abuse & Neglect. 1988;12:51–59
  13. Brown GR, Anderson B. Psychiatric morbidity in adult inpatients with childhood histories of sexual and physical abuse. American Journal of Psychiatry. 1991;148:55–61
  14. Brown GW, Moran P. Clinical and psychosocial origins of chronic depressive episodes I: A community survey. British Journal of Psychiatry. 1994;165:447–456
  15. Brown GW, Harris TO, Hepworth C, Robinson R. Clinical and psychosocial origins of chronic depressive episodes II: A patient enquiry. British Journal of Psychiatry. 1994;165:457–465
  16. Buss C, Lord C, Wadiwalla M, Hellhammer DH, Lupien SJ, Meaney MJ, et al. Maternal care modulates the relationship between prenatal risk and hippocampal volume in women but not in men. Journal of Neuroscience. 2007;27:2592–2595
  17. Caldji C, Tannenbaum B, Sharma S, Francis D, Plotsky PM, Meany MJ. Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Proceedings of the National Academy of Sciences of the United States of America. 1998;95:5335–5340
  18. Caldji C, Francis D, Sharma S, Plotsky PM, Meany MJ. The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat. Neuropsychopharmacology. 2000;22:219–229
  19. Carlin AS, Kemper K, Ward NG, Sowell H, Gustafson B, Stevens N. The effect of differences in objective and subjective definitions of childhood physical abuse on estimates of its incidence and relationship to psychopathology. Child Abuse & Neglect. 1994;18:393–399
  20. Coplan JD, Andrews MW, Rosenblum LA, Owens MJ, Friedman S, Gorman JM, et al. Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. Proceedings of the National Academy of Sciences of the United States of America. 1996;93:1619–1623
  21. Czeh B, Michaelis T, Watanabe T, Frahm J, de Biurrun G, van Kampen M, et al. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proceedings of the National Academy of Sciences of the United States of America. 2001;98:12796–12801
  22. Dettling AC, Feldon J, Pryce CR. Repeated parental deprivation in the infant common marmoset (Callithrix jacchus, primates) and analysis of its effects on early development. Biological Psychiatry. 2002;52:1037–1046
  23. Driessen M, Herrmann J, Stahl K, Zwaan M, Szilvia M, Hill A, et al. Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization. Archives of General Psychiatry. 2000;57:1115–1122
  24. D'Sa C, Duman RS. Antidepressants and neuroplasticity. Bipolar Disorder. 2002;4:183–194
  25. Dube SR, Anda RF, Felitti VJ, Chapman DP, Williamson DF, Giles WH. Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: findings from the adverse childhood experiences study. Journal of the American Medical Association. 2001;286:3089–3096
  26. Francis DD, Young LJ, Meaney MJ, Insel TR. Naturally occurring differences in maternal care are associated with the expression of oxytocin and vasopressin receptors: gender differences. Journal of Neuroendocrinology. 2002;14:349–353
  27. Frodl T, Meisenzahl EM, Zill P, Baghai T, Rujescu D, Leinsinger G, et al. Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression. Archives of General Psychiatry. 2004;61:177–183
  28. Gilman SE, Kawachi I, Fitzmaurice GM, Buka SL. Socio-economic status, family disruption and residential stability in childhood: relation to onset, recurrence and remission of major depression. Psychological Medicine. 2003;33:1341–1355
  29. Hamilton M. A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry. 1960;23:56–62
  30. Hammen C, Risha H, Daley SE. Depression and sensitization to stressors among young women as a function of childhood adversity. Journal of Consulting and Clinical Psychology. 2000;68:782–787
  31. Harkness KL, Monroe SM. Childhood adversity and the endogenous versus nonendogenous distinction in women with major depression. American Journal of Psychiatry. 2002;159:387–393
  32. Heim C, Nemeroff CB. The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biological Psychiatry. 2001;49:1023–1039
  33. Heim C, Newport DJ, Heit S, Graham YP, Wilcox M, Bonsall R, et al. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. Journal of the American Medical Association. 2000;284:592–597
  34. Heim C, Plotsky PM, Nemeroff CB. Importance of studying the contributions of early adverse experience to neurobiological findings in depression. Neuropsychopharmacology. 2004;29:641–648
  35. Huot RL, Plotsky PM, Lenox RH, Mc Namara RK. Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats. Brain Research. 2002;950:52–63
  36. Jacobs BL, Praag H, Gage FH. Adult brain neurogenesis and psychiatry: a novel theory of depression. Molecular Psychiatry. 2000;5:262–269
  37. Jimenez-Vasquez PA, Mathe AA, Thomas JD, Riley EP, Ehlers CL. Early maternal separation alters neuropeptide Y concentrations in selected brain regions in adult rats. Brain Research and Developmental Brain Research. 2001;131:149–152
  38. Kalbfleisch JD, Prentice RL. The Statistical Analysis of Failure Time Data. New York: John Wiley; 1980;
  39. Kaplan MJ, Klinetob NA. Childhood emotional trauma and chronic posttraumatic stress disorder in adult outpatients with treatment-resistant depression. Journal of Nervous and Mental Disease. 2000;188:596–601
  40. Kessler RC, Magee WJ. Childhood adversities and adult depression: basic patterns of association in a US national survey. Psychological Medicine. 1993;23:679–690
  41. Kessler RC, Davis CG, Kendler KS. Childhood adversity and adult psychiatric disorder in the US National Comorbidity Survey. Psychological Medicine. 1997;27:1101–1119
  42. Ladd CO, Huot RL, Thrivikraman KV, Nemeroff CB, Meaney MJ, Plotsky PM. Long-term behavioral and neuroendocrine adaptations to adverse early experience. Progress in Brain Research. 2000;122:81–103
  43. Lara ME, Klein DN, Kasch KL. Psychosocial predictors of the short-term course and outcome of major depression: A longitudinal study of a nonclinical sample with recent-onset episodes. Journal of Abnormal Psychology. 2000;109:644–650
  44. Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A, et al. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science. 1997;277:1659–1662
  45. Liu D, Caldji C, Sharma S, Plotsky PM, Meaney MJ. Influence of neonatal rearing conditions on stress-induced adrenocorticotropin responses and norepinepherin release in the hypothalamic paraventricular nucleus. Journal of Neuroendocrinology. 2000;12:5–12
  46. Lyons DM, Martel FL, Levine S, Risch NJ, Schatzberg AF. Postnatal experiences and genetic effects on squirrel monkey social affinities and emotional distress. Hormones and Behavior. 1999;36:266–275
  47. Lyons DM, Yang C, Mobley BW, Nickerson JT, Schatzberg AF. Early environmental regulation of glucocorticoid feedback sensitivity in young adult monkeys. Journal of Neuroendocrinology. 2000;12:723–728
  48. Lyons DM, Yang C, Sawyer-Glover AM, Moseley ME, Schatzberg AF. Early life stress and inherited variation in monkey hippocampal volumes. Archives of General Psychiatry. 2001;58:1145–1151
  49. Maestripieri D. The biology of human parenting: insights from nonhuman primates. Neuroscience and Biobehavior Review. 1999;23:411–422
  50. Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. Journal of Neuroscience. 2000;20:9104–9110
  51. Manev H, Uz T, Smallheiser NR, Manev R. Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro. European Journal of Pharmacology. 2001;411:67–70
  52. McHolm AE, MacMillan HL, Jamieson E. The relationship between childhood physical abuse and suicidality among depressed women: results from a community sample. American Journal of Psychiatry. 2003;160:933–938
  53. Meaney MJ, Diorio J, Franci D, Widdowson J, LaPlante P, Caldji C, et al. Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Developmental Neuroscience. 1996;18:49–72
  54. Miliken GA, Johnson DE. Analysis of Messy Data, Volume 3 : Analysis of Covariance. New York: Chapman & Hall/CRC; 2001;
  55. Mintun MA, Sheline YI, Moerlein SM, Vlassenko AG, Huang Y, Snyder AZ. Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F] Altanserin positron emission tomography. Biological Psychiatry. 2004;55:217–224
  56. Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43:2412–2414
  57. Mullen PE, Martin JL, Anderson JC, Romans SE, Herbison GP. The long-term impact of the physical, emotional, and sexual abuse of children: a community study. Child Abuse & Neglect. 1996;20:7–21
  58. Nurnberger JI, Blehar MC, Kauffmann CA, York-Coller C, Simpson SG, Harkavy-Friedman J, et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Archives of General Psychiatry. 1994;51:849–859
  59. O'Brien JT, Lloyd A, McKeith I, Gholkar A, Ferrier N. A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects. American Journal of Psychiatry. 2004;161:2081–2090
  60. Parker G. Parental characteristics in relation to depressive disorders. British Journal of Psychiatry. 1979;134:138–147
  61. Parker G, Hadzi-Pavlovic D, Greenwald S, Weissman M. Low parental care as a risk factor to lifetime depression in a community sample. Journal of Affective Disorders. 1995;33:173–180
  62. Parker G, Roussos J, Hadzi-Pavlovic D, Mitchell P, Wilhelm K, Austin M-P. The development of a refined measure of dysfunctional parenting and assessment of its relevance in patients with affective disorders. Psychological Medicine. 1997;27:1193–1203
  63. Pitman RK, Gilbertson MW, Gurvits TV, May FS, Lasko NB, Metzger LJ, et al. Clarifying the origins of biological abnormality in PTSD through the study of identical twins discordant for combat exposure. Annals of the New York Academy of Sciences. 2006;1071:242–254
  64. Plotsky PM, Meaney MJ. Early postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Molecular Brain Research. 1993;18:195–200
  65. Plotsky PM, Sanchez MM, Levine S. Intrinsic and extrinsic factors modulating physiological coping systems during development. In:  Broom DM editors. Coping with Challenge. Berlin: Dahlem University Press; 2001;p. 169–196
  66. Post RM, Roy-Byrne PP, Uhde TW. Graphic representation of the life course of illness in patients with affective disorder. American Journal of Psychiatry. 1988;145:844–848
  67. Rinne T, de Kloet ER, Wouters L, Goekoop JG, DeRijk RH, van den Brink W. Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse. Biological Psychiatry. 2002;52:1102–1112
  68. Rosenblum LA, Coplan JD, Friedman S, Bassoff T, Gorman JM, Andrews MW. Adverse early experiences affect noradrenergic and serotenergic functioning in adult primates. Biological Psychiatry. 1994;35:221–227
  69. Rosenblum LA, Forger C, Noland S, Trost RC, Coplan JD. Response of adolescent bonnet macaques to an acute fear stimulus as a function of early rearing conditions. Developmental Psychobiology. 2002;39:40–45
  70. Sakado K, Sato T, Uehara T, Sakado M, Someya T. Perceived parenting pattern and response to antidepressants in patients with major depression. Journal of Affective Disorders. 1999;52:59–66
  71. Sedney MA, Brooks B. Factors associated with a history of childhood sexual experience in a nonclinical female population. Journal of the Academy of Child and Adolescent Psychiatry. 1984;23:215–218
  72. Sheline YI. Neuroimaging studies of mood disorder effects on the brain. Biological Psychiatry. 2003;54:338–352
  73. Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MV. Hippocampal atrophy in recurrent major depression. Proceedings of the National Academy of Sciences of the United States of America. 1996;93:3908–3913
  74. Sheline YI, Sanghavi M, Mintun MA, Gado MH. Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent depression. Journal of Neuroscience. 1999;19:5034–5043
  75. Stein MB, Koverola C, Hanna C, Torchia MG, McClarty B. Hippocampal volume in women victimized by childhood sexual abuse. Psychological Medicine. 1997;27:951–959
  76. Taylor WD, Steffens DC, Payne ME, MacFall JR, Marchuk DA, Svenson IK, et al. Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. Archives of General Psychiatry. 2005;62:537–544
  77. Vermetten E, Schmahl C, Lindner S, Loewenstein RJ, Bremner JD. Hippocampal and amygdalar volumes in Dissociative Identity Disorder. American Journal of Psychiatry. 2006;163:630–636
  78. Videbech P, Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. American Journal of Psychiatry. 2004;161:1957–1966
  79. Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R. Childhood trauma associated with smaller hippocampal volume in women with major depression. American Journal of Psychiatry. 2002;159:2072–2080
  80. Vythilingam M, Vermetten E, Anderson GM, Luckenbaugh D, Anderson ER, Snow J, et al. Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biological Psychiatry. 2004;56:101–112
  81. Weiss EL, Longhurst JG, Mazure CM. Childhood sexual abuse as a risk factor for depression in women: psychosocial and neurobiological correlates. American Journal of Psychiatry. 1999;156:816–828
  82. Widom CS, Dumont K, Czaja SJ. A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Archives of General Psychiatry. 2007;64:49–56
  83. Young EA, Abelson JL, Curtis GC, Nesse RM. Childhood adversity and vulnerability to mood and anxiety disorders. Depression and Anxiety. 1997;5:66–72
  84. Zlotnick C, Ryan CE, Miller IW, Keitner GI. Childhood abuse and recovery from major depression. Child Abuse & Neglect. 1995;19:1513–1516

PII: S0925-4927(07)00090-X

doi: 10.1016/j.pscychresns.2007.04.004

Psychiatry Research: Neuroimaging
Volume 162, Issue 1 , Pages 39-49 , 15 January 2008

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