Psychiatry Research: Neuroimaging
Volume 164, Issue 1 , Pages 48-57 , 30 October 2008

Metabolic changes in the brain of patients with late-onset major depression

  • Toshiro Fujimoto

      Affiliations

    • Department Psychiatry of Faculty of Medicine of University of Tokyo, 7–3–1 Hongo, Bunkyo–ku, Tokyo, 113–8655, Japan
    • Corresponding Author InformationCorresponding author. 17–4, Hayasuzu–cho, Miyakonojo, 885-0055, Japan. Tel.: +81 986 25 1313; fax: +81 986 25 3950.
    web address
  • ,
  • Kouzou Takeuchi

      Affiliations

    • Fujimoto Hospital, Yokakai Foundation, 17–4, Hayasuzu–cho, Miyakonojo, 885–0055, Japan
    • Tel.: +81 986 25 1313; fax: +81 986 25 3950.
  • ,
  • Tetsuro Matsumoto

      Affiliations

    • Fujimoto Hospital, Yokakai Foundation, 17–4, Hayasuzu–cho, Miyakonojo, 885–0055, Japan
    • Tel.: +81 986 25 1313; fax: +81 986 25 3950.
  • ,
  • Seigo Fujita

      Affiliations

    • Fujimoto Hospital, Yokakai Foundation, 17–4, Hayasuzu–cho, Miyakonojo, 885–0055, Japan
    • Tel.: +81 986 25 1313; fax: +81 986 25 3950.
  • ,
  • Kenichi Honda

      Affiliations

    • Fujimoto Hospital, Yokakai Foundation, 17–4, Hayasuzu–cho, Miyakonojo, 885–0055, Japan
    • Tel.: +81 986 25 1313; fax: +81 986 25 3950.
  • ,
  • Yuji Higashi

      Affiliations

    • Fujimoto Hospital, Yokakai Foundation, 17–4, Hayasuzu–cho, Miyakonojo, 885–0055, Japan
    • Tel.: +81 986 25 1313; fax: +81 986 25 3950.
  • ,
  • Nobumasa Kato

      Affiliations

    • Department Psychiatry of Faculty of Medicine of University of Tokyo, 7–3–1 Hongo, Bunkyo–ku, Tokyo, 113–8655, Japan

Received 14 July 2006 ,Revised 16 December 2006 ,Accepted 27 March 2007.

References 

  1. Baker SC, Frith CD, Dolan RJ. The interaction between mood and cognitive function studied with PET. Psychological Medicine. 1997;27:565–578
  2. Baxter LR, Schwartz JM, Phelps ME, Mazziotta JC, Guze BH, Selin CE, et al. Reduction of prefrontal cortex glucose metabolism common to three types of depression. Archives of General Psychiatry. 1989;46:243–250
  3. Bench CJ, Friston KJ, Brown RG, Scott LC, Frackowiak RSJ, Dolan RJ. The anatomy of melancholia — focal abnormalities of cerebral blood flow in major depression. Psychological Medicine. 1992;22:607–615
  4. Bench CJ, Friston KJ, Brown RG, Frackowiak RSJ, Dolan RJ. Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions. Psychological Medicine. 1993;23:579–590
  5. Bench CJ, Frackowiak RSJ, Dolan RJ. Changes in regional cerebral blood flow on recovery from depression. Psychological Medicine. 1995;25:247–261
  6. Biver F, Goldman S, Delvenne V, Luxen A, De Maertelaer V, Hubain P, et al. Frontal and parietal metabolic disturbances in unipolar depression. Biological Psychiatry. 1994;36:381–388
  7. Brody AL, Saxena S, Silverman DHS, Alborzian S, Fairbanks LA, Phelps ME, et al. Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine. Psychiatry Research: Neuroimaging. 1999;91:127–139
  8. Bruehl C, Kloiber O, Hossman KA, Dorn T, Witte OW. Regional hypometabolism in an acute model of focal epileptic activity in the rat. European Journal of Neuroscience. 1995;7:192–197
  9. Bruehl C, Wagner U, Huston JP, Witte OW. Thalamocortical circuits causing remote hypometabolism during focal interictal epilepsy. Epilepsy Research. 1998;32:379–387
  10. Buchsbaum MS, DeLisi LE, Holcomb HH, Cappelletti J, King AC, Johnson J, et al. Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Archives of General Psychiatry. 1984;41:1159–1166
  11. Buchsbaum MS, Wu J, DeLisi LE, Holcomb H, Kessler R, Johnson J, et al. Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with [18F]2-deoxyglucose in affective illness. Journal of Affective Disorders. 1986;10:137–152
  12. Buchsbaum MS, Wu J, Siegel BV, Hackett E, Trenary M, Abel L, et al. Effect of sertraline on regional metabolic rate in patients with affective disorder. Biological Psychiatry. 1997;41:15–22
  13. Bush G, Vogt BA, Holmes J, Dale AM, Greve D, Jenike MA, et al. Dorsal anterior cingulate cortex: a role in reward-based decision making. Proceedings of the National Academy of Sciences of the United States of America. 2002;99:523–528
  14. Clark CP, Brown GG, Frank L, Thomas L, Sutherland AN, Gillin JC. Improved anatomic delineation of the antidepressant response to partial sleep deprivation in medial frontal cortex using perfusion-weighted functional MRI. Psychiatry Research: Neuroimaging. 2006;146:213–222
  15. Conway CR, Sheline YI, Chibnall JT, George MS, Fletcher JW, Mintun MA. Cerebral blood flow changes during vagus nerve stimulation for depression. Psychiatry Research: Neuroimaging. 2006;146:179–184
  16. Davidson RJ, Lewis DA, Alloy LB, Amaral DG, Bush G, Cohen JD, et al. Neural and behavioral substrates of mood and mood regulation. Biological Psychiatry. 2002;52:478–502
  17. Devinsky O, Morrell MJ, Vogt BA. Contributions of anterior cingulate cortex to behaviour. Brain. 1995;118:279–306
  18. Dolan RJ, Bench CJ, Brown RG, Scott LC, Friston KJ, Frackowiak RSJ. Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment. Journal of Neurology, Neurosurgery and Psychiatry. 1992;55:768–773
  19. Drevets WC. Functional neuroimaging studies of depression: the anatomy of melancholia. Annual Review of Medicine. 1998;49:341–361
  20. Drevets WC, Charney DS. Anxiety disorders: neuroimaging. In:  Sadock BJ,  Sadock VA editor. Comprehensive Textbook of Psychiatry I. Philadelphia: Lippincott Williams & Wilkins; 2005;p. 1748–1758
  21. Drevets WC, Raichle ME. Neuroanatomical circuits in depression: implications for treatment mechanisms. Psychopharmacology Bulletin. 1992;28:261–274
  22. Drevets WC, Price JL, Simpson JR, Todd RD, Reich T, Vannier M, et al. Subgenual prefrontal cortex abnormalities in mood disorders. Nature. 1997;386:824–827
  23. Dunn RT, Willis MW, Benson BE, Repella JD, Kimbrell TA, Ketter TA, et al. Preliminary findings of uncoupling of flow and metabolism in unipolar compared with bipolar affective illness and normal controls. Psychiatry Research: Neuroimaging. 2005;140:181–198
  24. Ebert D, Ebmeier KP. The role of the cingulate gyrus in depression: from functional anatomy to neurochemistry. Biological Psychiatry. 1996;39:1044–1050
  25. Elliott R, Baker SC, Rogers RD, O'Leary DA, Paykel ES, Frith CD, et al. Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography. Psychological Medicine. 1997;27:931–942
  26. Flor-Henry P. Psychosis and temporal lobe epilepsy: a controlled investigation. Epilepsia. 1969;10:363–395
  27. Flor-Henry P. Hemispheric laterality and disorders of affect. In: Cerebral Basis of Psychopathology. USA: John Wright-PSG Inc.; 1983;p. 39–57
  28. Ketter TA, Kimbrell TA, George MS, Dunn RT, Speer AM, Benson BE, et al. Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder. Biological Psychiatry. 2001;49:97–109
  29. Kimbrell TA, Ketter TA, George MS, Little JT, Benson BE, Willis MW, et al. Regional cerebral glucose utilization in patients with a range of severities of unipolar depression. Biological Psychiatry. 2002;51:237–252
  30. Martinot J-L, Hardy P, Feline A, Huret J-D, Mazoyer B, Attar-Levy D, et al. Left prefrontal glucose hypometabolism in the depressed state: a confirmation. The American Journal of Psychiatry. 1990;147:1313–1317
  31. Mayberg HS, Lewis PJ, Regenold W, Wagner HN. Paralimbic hypoperfusion in unipolar depression. Journal of Nuclear Medicine. 1994;35:929–934
  32. Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, et al. Reciprocal limbic–cortical function and negative mood: converging PET findings in depression and normal sadness. The American Journal of Psychiatry. 1999;156:675–682
  33. Milak MS, Parsey RV, Keilp J, Oquendo MA, Malone KM, Mann JJ. Neuroanatomic correlates of psychopathologic components of major depressive disorder. Archives of General Psychiatry. 2005;62:397–408
  34. Minoshima S. Imaging Alzheimer's disease: clinical applications. Neuroimaging Clinics of North America. 2003;13:769–780
  35. Minoshima S, Koeppe RA, Frey KA, Kuhl DE. Anatomic standardization: linear scaling and nonlinear warping of functional brain images. Journal of Nuclear Medicine. 1994;35:1528–1537
  36. Minoshima S, Frey KA, Koeppe RA, Foster NL, Kuhl DE. A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. Journal of Nuclear Medicine. 1995;36:1238–1248
  37. Post RM, DeLisi LE, Holcomb HH, Uhde TW, Cohen R, Buchsbaum MS. Glucose utilization in the temporal cortex of affectively ill patients: positron emission tomography. Biological Psychiatry. 1987;22:545–553
  38. Smith KA, Ploghaus A, Cowen PJ, McCleery JM, Goodwin GM, Smith S, et al. Cerebellar responses during anticipation of noxious stimuli in subjects recovered from depression. The British Journal of Psychiatry. 2002;181:411–415
  39. Soares JC, Mann JJ. The anatomy of mood disorders—review of structural neuroimaging studies. Biological Psychiatry. 1997;41:86–106
  40. Szuba MP, Baxter LR, Fairbanks LA, Guze BH, Schwartz JM. Effects of partial sleep deprivation on the diurnal variation of mood and motor activity in major depression. Biological Psychiatry. 1991;30:817–829
  41. Talairach J, Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain. New York: Thieme Medical; 1988;
  42. Trimble MR, Ring HA, Schmitz B. Neuropsychiatric aspects of epilepsy. In:  Fogel BS,  Schiffer RB editor. Neuropsychiatry. USA: Williams & Wilkins; 1996;p. 771–803
  43. Vogt BA, Finch DM, Olson CR. Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cerebral Cortex. 1992;2:435–443
  44. Wu JC, Gillin JC, Buchsbaum MS, Hershey T, Johnson JC, Bunney WE. Effect of sleep deprivation on brain metabolism of depressed patients. The American Journal of Psychiatry. 1992;149:538–543
  45. Wu J, Buchsbaum MS, Gillin JC, Tang C, Cadwell S, Wiegand M, et al. Prediction of antidepressant effects of sleep deprivation by metabolic rates in the ventral anterior cingulate and medial prefrontal cortex. The American Journal of Psychiatry. 1999;156:1149–1158
  46. Zobel A, Joe A, Freymann N, Clusmann H, Schramm J, Reinhardt M, et al. Changes in regional cerebral blood flow by therapeutic vagus nerve stimulation in depression: an exploratory approach. Psychiatry Research: Neuroimaging. 2005;139:165–179

PII: S0925-4927(07)00083-2

doi: 10.1016/j.pscychresns.2007.03.010

Psychiatry Research: Neuroimaging
Volume 164, Issue 1 , Pages 48-57 , 30 October 2008