Psychiatry Research: Neuroimaging
Volume 162, Issue 1 , Pages 1-9 , 15 January 2008

Cortical dopamine D1 receptors in type 1 and type 2 alcoholics measured with human whole hemisphere autoradiography

  • Erkki Tupala

      Affiliations

    • Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Finland
    • Department of Pharmacology and Toxicology, University of Kuopio, Finland
    • Deceased.
  • ,
  • Jari Tiihonen

      Affiliations

    • Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Finland
    • Department of Clinical Physiology, Kuopio University Hospital, Finland
    • Corresponding Author InformationCorresponding author. University of Kuopio, Department of Forensic Psychiatry, Niuvanniemi Hospital, FI-70240 Kuopio, Finland. Tel.: +358 17 203 111; fax: +358 17 203 494.

Received 2 May 2005 ,Revised 14 August 2006 ,Accepted 21 August 2006.

References 

  1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 3rd ed, revised. Washington, DC: American Psychiatric Press; 1987;
  2. Bechara A, Damasio AR, Damasio H, Anderson SW. Insensitivity to future consequences following damage to human prefrontal cortex. Cognition. 1994;50:7–15
  3. Cloninger CR. The psychobiological regulation of social co-operation. Nature Medicine. 1995;1:623–624
  4. Cloninger CR, Bohman M, Sigvardsson S. Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. Archives of General Psychiatry. 1981;38:861–868
  5. Cohen J. A coefficient of agreement for nominal scales. Educational and Psychological Measurement. 1960;XX:37–46
  6. Cohen J. Statistical Power Analysis for the Behavioural Sciences. 2nd ed.. Hillsdale, New Jersey: Lawrence Erlbaum Associates, Publishers; 1988;
  7. Damasio AR, Van Hoesen GW. Emotional disturbances associated with focal lesions of the limbic frontal lobe. In:  Heilman KM,  Satz P editor. Neuropsychology of Human Emotion. New York, NY: The Guilford Press; 1983;p. 85–110
  8. Damasio H, Grabowski T, Randall F, Galaburda AM, Damasio AR. The return of Phineas Gage: clues about the brain from the skull of a famous patient. Science. 1994;264:1102–1105
  9. Davidson RJ, Putnam KM, Larson CL. Dysfunction in the neural circuitry of emotion regulation—a possible prelude to violence. Science. 2000;289:591–594
  10. de Montis MG, Gambarana C, Gessa GL, Meloni D, Tagliamonte A, Stefanini F. Reduced [3H]SCH 23390 binding and DA-sensitive adenylyl cyclase in the limbic system of ethanol-preferring rats. Alcohol and Alcoholism. 1993;28:397–400
  11. Devinsky O, Morrell MJ, Vogt BA. Contributions of anterior cingulate cortex to behaviour. Brain. 1995;118:279–306
  12. di Chiara G, Imperato A. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proceedings of the National Academy of Sciences of the United States of America. 1988;85:5274–5278
  13. Dyr W, McBride WJ, Lumeng L, Li TK, Murphy JM. Effects of D1 and D2 dopamine receptor agents on ethanol consumption in the high-alcohol-drinking (HAD) line of rats. Alcohol. 1993;10:207–212
  14. Eiler WJ, Seyoum R, Foster KL, Mailey C, June HL. D1 dopamine receptor regulates alcohol-motivated behaviors in the bed nucleus of the stria terminalis in alcohol-preferring (P) rats. Synapse. 2003;48:45–56
  15. El-Ghundi M, George SR, Drago J, Fletcher PJ, Fan T, Nguyen T, et al. Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behavior. European Journal of Pharmacology. 1998;353:149–158
  16. Hall H. Dopamine receptors: radioligands for pharmacological and biochemical characterization. In:  Niznik HB editors. Dopamine Receptors and Transporters. New York: Marcel Dekker Inc. Publisher; 1994;p. 345–399
  17. Hall H, Sedvall G, Magnusson O, Kopp J, Halldin C, Farde L. Distribution of D1 and D2-dopamine receptors and dopamine and its metabolites in the human brain. Neuropsychopharmacology. 1994;4:245–256
  18. Hall H, Farde L, Halldin C, Hurd YL, Pauli S, Sedvall G. Autoradiographic localization of extra-striatal D2-dopamine receptors in the human brain using [125I]Epidepride. Synapse. 1996;23:115–123
  19. Hall H, Halldin C, Dijkstra D, Wikström H, Wise LD, Pugsley TA, et al. Autoradiographic localization of D3-dopamine receptors in the human brain using the selective D3-dopamine receptor agonist (+)-[3H]PD 128 907. Psychopharmacology. 1996;128:240–247
  20. Hall H, Halldin C, Guilloteau D, Chalon S, Emond P, Besnard J-C, et al. Visualization of the dopamine transporter in the human brain postmortem with the new selective ligand [125I]PE2I. NeuroImage. 1999;9:108–116
  21. Hartman DS, Lanau F. Diversity of dopamine receptors: new molecular and pharmacological developments. Poland Journal of Pharmacology. 1997;49:191–199
  22. Hietala J, West C, Syvälahti E, Någren K, Lehikoinen P, Sonninen P, et al. Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence. Psychopharmacology (Berlin). 1994;116:285–290
  23. Hodge CW, Samson HH, Chappelle AM. Alcohol self-administration: further examination of the role of dopamine receptors in the nucleus accumbens. Alcoholism, Clinical and Experimental Research. 1997;21:1083–1091
  24. Joyce JN, Murray A. Distribution of D1- and D2-like dopamine receptors in human brain. In:  Niznik HB editors. Dopamine Receptors and Transporters. New York: Marcel Dekker Inc. Publisher; 1994;p. 345–381
  25. Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–174
  26. Mantere T, Tupala E, Hall H, Särkioja T, Räsänen P, Bergström K, et al. Serotonin transporter distribution and density in the cerebral cortex of alcoholic and nonalcoholic comparison subjects: a whole-hemisphere autoradiography study. American Journal of Psychiatry. 2002;159:599–606
  27. McBride WJ, Chernet E, Russell RN, Chamberlain JK, Lumeng L, Li T-K. Regional CNS densities of serotonin and dopamine receptors in high alcohol-drinking (HAD) and low-alcohol drinking (LAD) rats. Alcohol. 1997;14:603–609
  28. McBride WJ, Chernet E, Russell RN, Wong DT, Guan XM, Lumeng L, et al. Regional CNS densities of monoamine receptors in alcohol naive alcohol-preferring P and -nonpreferring NP rats. Alcohol. 1997;14:141–148
  29. Mogenson GJ, Jones DL, Yim CY. From motivation to action: functional interface between the limbic system and the motor system. Progress in Neurobiology. 1980;14:69–97
  30. Ng GY, O'Dowd BF, George SR. Genotypic differences in brain dopamine receptor function in the DBA/2J and C57BL/6J inbred mouse strains. European Journal of Pharmacology. 1994;269:349–364
  31. Niewenhuys R, Voogd J, vanHuijzen C. The Human Central Nervous System: a Synopsis and Atlas. 3rd ed.. Berlin, Heidelberg: Springer-Verlag; 1988;
  32. Repo E, Kuikka JT, Bergström KA, Karhu J, Hiltunen J, Tiihonen J. Dopamine transporter and D2-receptor density in late onset alcoholism. Psychopharmacology. 1999;147:314–318
  33. Quadros IM, Nobrega JN, Hipolide DC, de Lucca EM, Souza-Formigoni ML. Differential propensity to ethanol sensitization is not associated with altered binding to D1 receptors or dopamine transporters in mouse brain. Addiction Biology. 2002;7:291–299
  34. Shapiro SS, Wilk MB, Chen HJ. A comparative study of various tests for normality. Journal of the American Statistical Association. 1968;63:1343–1372
  35. Short JL, Rezvani A, Lawrence AJ. [3H]Dopamine release and dopamine receptor autoradiography in alcohol preferring rats. Proceedings of the Australian Neuroscience Society. 1998;9:81
  36. Silvestre JS, O'Neill MF, Fernandez AG, Palacios JM. Effects of a range of dopamine receptor agonists and antagonists on ethanol intake in the rat. European Journal of Pharmacology. 1996;318:257–265
  37. Syvälahti EKG, Pohjalainen T, Korpi ER, Pälvimäki E-P, Ovaska T, Kuoppamäki M, et al. Dopamine D2 receptor gene expression in rat lines selected for differences in voluntary alcohol consumption. Alcoholism, Clinical and Experimental Research. 1994;18:1029–1031
  38. Tiihonen J, Kuikka J, Bergström K, Hakola P, Karhu J, Ryynänen O-P, et al. Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics. Nature Medicine. 1995;7:654–657
  39. Tomic M, Vukosavic S, Joksimovic J. Acute amphetamine and/or phencyclidine effects on the dopamine receptor specific binding in the rat brain. European Neuropsychopharmacology. 1997;7:295–301
  40. Träskman-Bendz L. Whole brain serotonin- and dopamine transporters in suicide attempters and controls. Iceland Medical Journal. 2003;48:22
  41. Tupala E, Tiihonen J. Dopamine and alcoholism: neurobiological basis of ethanol abuse. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2004;28:1221–1247
  42. Tupala E, Tiihonen J. Striatal dopamine D1 receptors in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography. Brain Research. 2005;1031:20–29
  43. Tupala E, Hall H, Särkioja T, Räsänen P, Tiihonen J. Dopamine transporter density in nucleus accumbens of type-1 alcoholics. Lancet. 2000;355:380
  44. Tupala E, Hall H, Bergström K, Särkioja T, Räsänen P, Mantere T, et al. Dopamine D2/D3-receptor and transporter densities in nucleus accumbens and amygdala of type 1 and 2 alcoholics. Molecular Psychiatry. 2001;6:261–267
  45. Tupala E, Kuikka JT, Hall H, Bergström KA, Särkioja T, Räsänen P, et al. Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography. NeuroImage. 2001;14:87–94
  46. Tupala E, Hall H, Bergström K, Mantere T, Räsänen P, Särkioja T, et al. Striatal dopamine D2 receptors and transporters in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography. Human Brain Mapping. 2003;20:91–102
  47. Tupala E, Hall H, Mantere T, Räsänen P, Särkioja T, Tiihonen J. Dopamine receptors and transporters in the brain reward circuits of type 1 and 2 alcoholics measured with whole hemisphere autoradiography. NeuroImage. 2003;19:145–155
  48. Tupala E, Hall H, Mantere T, Räsänen P, Särkioja T, Tiihonen J. Cortical dopamine D2 receptors in type 1 and 2 alcoholism measured with human whole hemisphere autoradiography. Synapse. 2004;54:129–137
  49. Tupala E, Hall H, Tiihonen J. Visualization of the cortical dopamine D3 receptors in alcoholics and controls with human whole hemisphere autoradiography. Psychopharmacology. 2005;181:412–413
  50. Tupala E, Halonen P, Tiihonen J. Visualization of the cortical dopamine transporter in type 1 and 2 alcoholic with human whole hemisphere autoradiography. European Neuropsychopharmacology. 2006;16:552–560
  51. Volkow ND, Wang GJ, Fowler JS, Logan J, Hitzemann R, Ding YS, et al. Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcoholism, Clinical and Experimental Research. 1996;20:1594–1598
  52. Worsley JN, Moszczynska A, Falardeau P, Kalasinsky KS, Schmunk G, Guttman M, et al. Dopamine D1 receptor protein is elevated in nucleus accumbens of human, chronic methamphetamine users. Molecular Psychiatry. 2000;5:664–672
  53. Zar JH. Biostatistical Analysis. 2nd ed.. Englewood Cliffs, New Jersey: Prentice-Hall Inc.; 1984;

PII: S0925-4927(07)00064-9

doi: 10.1016/j.pscychresns.2006.08.007

Psychiatry Research: Neuroimaging
Volume 162, Issue 1 , Pages 1-9 , 15 January 2008