Psychiatry Research: Neuroimaging
Volume 156, Issue 1 , Pages 83-86 , 15 October 2007

Reduced ventral anterior cingulate and amygdala volumes in medication-naïve females with major depressive disorder: A voxel-based morphometric magnetic resonance imaging study

  • Yanqing Tang

      Affiliations

    • Department of Psychiatry, The Second Xiangya Hospital, Central South University, 86, Mid-Renmin Road, Changsha, Hunan 410011, PR China
    • Department of Psychiatry, The First Affiliated Hospital, China Medical University, 92, Second-North Road, District Heping, Shenyang, Liaoning 110001, PR China
    • Y. Tang and F. Wang co-first authors.
    • ,
  • Fei Wang

      Affiliations

    • Institute of Mental Health, Peking University, 38 Xue Yuan Road, Beijing 100083, PR China
    • Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, United States
    • Department of Veterans Affairs, West Haven, CT 06516, United States
    • Y. Tang and F. Wang co-first authors.
    • ,
  • Guangrong Xie

      Affiliations

    • Department of Psychiatry, The Second Xiangya Hospital, Central South University, 86, Mid-Renmin Road, Changsha, Hunan 410011, PR China
    • Corresponding Author InformationCorresponding author. Tel.: +86 731 529 2160.
    • ,
  • Jun Liu

      Affiliations

    • Department of Radiology, The Second Xiangya Hospital, Central South University, 86, Mid-Renmin Road, Changsha, Hunan 410011, PR China
    • ,
  • Lehua Li

      Affiliations

    • Department of Psychiatry, The Second Xiangya Hospital, Central South University, 86, Mid-Renmin Road, Changsha, Hunan 410011, PR China
    • ,
  • Linyan Su

      Affiliations

    • Department of Psychiatry, The Second Xiangya Hospital, Central South University, 86, Mid-Renmin Road, Changsha, Hunan 410011, PR China
    • ,
  • Ying Liu

      Affiliations

    • Department of Psychiatry, The First Affiliated Hospital, China Medical University, 92, Second-North Road, District Heping, Shenyang, Liaoning 110001, PR China
    • ,
  • Xian Hu

      Affiliations

    • Department of Psychiatry, The First Affiliated Hospital, China Medical University, 92, Second-North Road, District Heping, Shenyang, Liaoning 110001, PR China
    • ,
  • Zhong He

      Affiliations

    • Department of Psychiatry, The Second Xiangya Hospital, Central South University, 86, Mid-Renmin Road, Changsha, Hunan 410011, PR China
    • ,
  • Hilary P. Blumberg

      Affiliations

    • Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, United States
    • Department of Veterans Affairs, West Haven, CT 06516, United States

Received 22 June 2006 ,Revised 26 January 2007 ,Accepted 14 March 2007.

References 

  1. Anand A, Li Y, Wang Y, Wu J, Gao S, Bukhari L, et al. Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biological Psychiatry. 2005;57:1079–1088
  2. Ashburner J, Friston KJ. Voxel-based morphometry—the methods. NeuroImage. 2000;11:805–821
  3. Ashburner J, Friston KJ. Unified segmentation. NeuroImage. 2005;26:839–851
  4. Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, et al. Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study. Biological Psychiatry. 2006;59:611–618
  5. Botteron KN, Raichle ME, Drevets WC, Heath AC, Todd RD. Volumetric reduction in left subgenual prefrontal cortex in early onset depression. Biological Psychiatry. 2002;51:342–344
  6. Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS. Hippocampal volume reduction in major depression. American Journal of Psychiatry. 2000;157:115–118
  7. Bremner JD, Vythilingam M, Vermetten E, Nazeer A, Adil J, Khan S, et al. Reduced volume of orbitofrontal cortex in major depression. Biological Psychiatry. 2002;51:273–279
  8. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences. 2000;4:215–222
  9. Chang K, Karchemskiy A, Barnea-Goraly N, Garrett A, Simeonova DI, Reiss A. Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 2005;44:565–573
  10. Cunningham MG, Bhattacharyya S, Benes FM. Amygdalo-cortical sprouting continues into early adulthood: implications for the development of normal and abnormal function during adolescence. Journal of Comparative Neurology. 2002;453:116–130
  11. Drevets WC. Prefrontal cortical–amygdalar metabolism in major depression. Annals of the New York Academy of Sciences. 1999;877:614–637
  12. Drevets WC, Price JL, Simpson JR, Todd RD, Reich T, Vannier M, et al. Subgenual prefrontal cortex abnormalities in mood disorders. Nature. 1997;386:824–827
  13. Duman RS, Malberg J, Thome J. Neural plasticity to stress and antidepressant treatment. Biological Psychiatry. 1999;46:1181–1191
  14. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I and II Disorders (Version 2.0). New York: New York State Psychiatric Institute, Biometrics Research Department; 1996;
  15. Frodl T, Meisenzahl EM, Zetzsche T, Born C, Jager M, Groll C, et al. Larger amygdala volumes in first depressive episode as compared to recurrent major depression and healthy control subjects. Biological Psychiatry. 2003;53:338–344
  16. Hamidi M, Drevets WC, Price JL. Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes. Biological Psychiatry. 2004;55:563–569
  17. Hamilton M. A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry. 1960;23:56–62
  18. Hastings RS, Parsey RV, Oquendo MA, Arango V, Mann JJ. Volumetric analysis of the prefrontal cortex, amygdala, and hippocampus in major depression. Neuropsychopharmacology. 2004;29:952–959
  19. Lange C, Irle E. Enlarged amygdala volume and reduced hippocampal volume in young women with major depression. Psychological Medicine. 2004;34:1059–1064
  20. Ongur D, Drevets WC, Price JL. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proceedings of the National Academy of Sciences of the United States of America. 1998;95:13290–13295
  21. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neuroscience. 2005;8:828–834
  22. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: implications for major psychiatric disorders. Biological Psychiatry. 2003;54:515–528
  23. Rosso IM, Cintron CM, Steingard RJ, Renshaw PF, Young AD, Yurgelun-Todd DA. Amygdala and hippocampus volumes in pediatric major depression. Biological Psychiatry. 2005;57:21–26
  24. Sassi RB, Nicoletti M, Brambilla P, Mallinger AG, Frank E, Kupfer DJ, et al. Increased gray matter volume in lithium-treated bipolar disorder patients. Neuroscience Letters. 2002;329:243–245
  25. Sheline YI, Gado MH, Kraemer HC. Untreated depression and hippocampal volume loss. American Journal of Psychiatry. 2003;160:1516–1518

PII: S0925-4927(07)00061-3

doi: 10.1016/j.pscychresns.2007.03.005

Psychiatry Research: Neuroimaging
Volume 156, Issue 1 , Pages 83-86 , 15 October 2007

Article Tools

* Image Usage & Resolution