Reduced ventral anterior cingulate and amygdala volumes in medication-naïve females with major depressive disorder: A voxel-based morphometric magnetic resonance imaging study

Tang, Yanqing; Wang, Fei; Xie, Guangrong; Liu, Jun; Li, Lehua; Su, Linyan; Liu, Ying; Hu, Xian; He, Zhong; Blumberg, Hilary P.

doi:10.1016/j.pscychresns.2007.03.005

« Previous Next »Psychiatry Research: Neuroimaging
Volume 156, Issue 1 , Pages 83-86, 15 October 2007

Reduced ventral anterior cingulate and amygdala volumes in medication-naïve females with major depressive disorder: A voxel-based morphometric magnetic resonance imaging study

Yanqing Tang
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 86, Mid-Renmin Road, Changsha, Hunan 410011, PR China
- Department of Psychiatry, The First Affiliated Hospital, China Medical University, 92, Second-North Road, District Heping, Shenyang, Liaoning 110001, PR China
- Y. Tang and F. Wang co-first authors.
Fei Wang
- Institute of Mental Health, Peking University, 38 Xue Yuan Road, Beijing 100083, PR China
- Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, United States
- Department of Veterans Affairs, West Haven, CT 06516, United States
- Y. Tang and F. Wang co-first authors.
Guangrong Xie
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 86, Mid-Renmin Road, Changsha, Hunan 410011, PR China
- Corresponding author. Tel.: +86 731 529 2160.
Jun Liu
- Department of Radiology, The Second Xiangya Hospital, Central South University, 86, Mid-Renmin Road, Changsha, Hunan 410011, PR China
Lehua Li
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 86, Mid-Renmin Road, Changsha, Hunan 410011, PR China
Linyan Su
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 86, Mid-Renmin Road, Changsha, Hunan 410011, PR China
Ying Liu
- Department of Psychiatry, The First Affiliated Hospital, China Medical University, 92, Second-North Road, District Heping, Shenyang, Liaoning 110001, PR China
Xian Hu
- Department of Psychiatry, The First Affiliated Hospital, China Medical University, 92, Second-North Road, District Heping, Shenyang, Liaoning 110001, PR China
Zhong He
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, 86, Mid-Renmin Road, Changsha, Hunan 410011, PR China
Hilary P. Blumberg
- Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, United States
- Department of Veterans Affairs, West Haven, CT 06516, United States

Received 22 June 2006; received in revised form 26 January 2007; accepted 14 March 2007.

Abstract

High resolution magnetic resonance imaging and voxel-based morphometry were used to compare regional gray matter volumes between 14 medication-naïve female participants with a first episode of major depressive disorder (MDD) and 13 female healthy comparison participants (HC). Volumes of bilateral ventral anterior cingulate cortex (vACC) and right amygdala were significantly smaller in the MDD group than in the HC group. These results suggest that volume reductions in vACC and amygdala in females with MDD are present at illness onset.

Keywords: Major depressive disorder, Magnetic resonance imaging, Voxel-based morphometry