Psychiatry Research: Neuroimaging
Volume 155, Issue 3 , Pages 265-269 , 15 August 2007

Influence of comorbid depression on fear in posttraumatic stress disorder: An fMRI study

  • Andrew H. Kemp

      Affiliations

    • Brain Dynamics Centre, Westmead Hospital and Western Clinical, School University of Sydney, Sydney, NSW, Australia
    • Corresponding Author InformationCorresponding author. The Brain Dynamics Centre, Acacia House, Hawkesbury Road, Westmead Hospital, Westmead NSW 2145, Australia. Tel.: +61 2 9845 6835; fax: +61 2 96357734.
    • ,
  • Kim Felmingham

      Affiliations

    • Brain Dynamics Centre, Westmead Hospital and Western Clinical, School University of Sydney, Sydney, NSW, Australia
    • ,
  • Pritha Das

      Affiliations

    • Brain Dynamics Centre, Westmead Hospital and Western Clinical, School University of Sydney, Sydney, NSW, Australia
    • Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, NSW, Australia
    • ,
  • Gerard Hughes

      Affiliations

    • Department of Radiology, Westmead Hospital, Sydney, NSW, Australia
    • ,
  • Anthony S. Peduto

      Affiliations

    • Brain Dynamics Centre, Westmead Hospital and Western Clinical, School University of Sydney, Sydney, NSW, Australia
    • Department of Radiology, Westmead Hospital, Sydney, NSW, Australia
    • ,
  • Richard A. Bryant

      Affiliations

    • Brain Dynamics Centre, Westmead Hospital and Western Clinical, School University of Sydney, Sydney, NSW, Australia
    • School of Psychology, University of New South Wales, Sydney, NSW, Australia
    • ,
  • Leanne M. Williams

      Affiliations

    • Brain Dynamics Centre, Westmead Hospital and Western Clinical, School University of Sydney, Sydney, NSW, Australia

Received 13 July 2006 ,Revised 9 January 2007 ,Accepted 28 January 2007.

References 

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  3. Davidson RJ, Pizzagalli D, Nitschke JB, Putnam K. Depression: perspectives from affective neuroscience. Annual Review of Psychology. 2002;53:545–574
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  5. Gilboa A, Shalev AY, Laor L, Lester H, Louzoun Y, Chisin R, et al. Functional connectivity of the prefrontal cortex and the amygdala in posttraumatic stress disorder. Biological Psychiatry. 2004;55:263–272
  6. Gur RC, Sara R, Hagendoorn M, Maron O, Hughgett P, Macy L, et al. A method for obtaining 3-dimensional facial expressions and its standardization for use in neurocognitive studies. Journal of Neuroscience Methods. 2002;115:137–143
  7. Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, et al. Reciprocal limbic–cortical function and negative mood: converging PET findings in depression and normal sadness. American Journal of Psychiatry. 1999;156:675–682
  8. Phan KL, Britton JC, Taylor SF, Fig LM, Liberzon I. Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder. Archives of General Psychiatry. 2006;63:184–192
  9. Sheline YI, Barch DM, Donnelly JM, Ollinger JM, Snyder AZ, Mintun MA. Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biological Psychiatry. 2001;50:651–658
  10. Shin LM, Wright CI, Cannistraro PA, Wedig MM, McMullin K, Martis B, et al. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Archives of General Psychiatry. 2005;62:273–281
  11. Shin LM, Rauch SL, Pitman RK. Amygdala, medial prefrontal cortex, and hippocampal function in PTSD. Annals of the New York Academy of Sciences. 2006;1071:67–79
  12. Thomas KM, Drevets WC, Dahl RE, Ryan ND, Birmaher B, Eccard CH, et al. Amygdala response to fearful faces in anxious and depressed children. Archives of General Psychiatry. 2001;58:1057–1063
  13. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. NeuroImage. 2002;15:273–289
  14. Williams LM, Kemp AH, Felmingham K, Barton M, Olivieri G, Peduto A, et al. Trauma modulates amygdala and medial prefrontal responses to consciously attended fear. NeuroImage. 2006;29:347–357

PII: S0925-4927(07)00034-0

doi: 10.1016/j.pscychresns.2007.01.010

Psychiatry Research: Neuroimaging
Volume 155, Issue 3 , Pages 265-269 , 15 August 2007

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