Assessment and prevention of head motion during imaging of patients with attention deficit hyperactivity disorder

Epstein, Jeffery N.; Casey, B.J.; Tonev, Simon T.; Davidson, Matthew; Reiss, Allan L.; Garrett, Amy; Hinshaw, Stephen P.; Greenhill, Laurence L.; Vitolo, Alan; Kotler, Lisa A.; Jarrett, Matthew A.; Spicer, Julie

doi:10.1016/j.pscychresns.2006.12.009

« Previous Next »Psychiatry Research: Neuroimaging
Volume 155, Issue 1 , Pages 75-82, 15 May 2007

Assessment and prevention of head motion during imaging of patients with attention deficit hyperactivity disorder

Jeffery N. Epstein
- Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, ML 10006, Cincinnati, OH 45229, United States
- Corresponding author. Tel.: +1 513 636 8296; fax: +1 513 636 0755.
B.J. Casey
- Sackler Institute and Neuroscience Program, Weill Medical College of Cornell University, New York, NY, United States
Simon T. Tonev
- Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States
Matthew Davidson
- Sackler Institute and Neuroscience Program, Weill Medical College of Cornell University, New York, NY, United States
Allan L. Reiss
- Department of Psychiatry, Stanford University Medical Center, Palo Alto, CA, United States
Amy Garrett
- Department of Psychiatry, Stanford University Medical Center, Palo Alto, CA, United States
Stephen P. Hinshaw
- Department of Psychology, University of California, Berkeley, CA, United States
Laurence L. Greenhill
- Division of Child Psychiatry, Columbia University Medical Center/New York State Psychiatric Institute, New York, NY, United States
Alan Vitolo
- Department of Psychology, University of California, Berkeley, CA, United States
Lisa A. Kotler
- Division of Child Psychiatry, Columbia University Medical Center/New York State Psychiatric Institute, New York, NY, United States
Matthew A. Jarrett
- Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States
Julie Spicer
- Sackler Institute and Neuroscience Program, Weill Medical College of Cornell University, New York, NY, United States

Received 29 August 2006; received in revised form 15 December 2006; accepted 26 December 2006.

Abstract

The present study serves to detail the specific procedures for a mock scanner protocol, report on its use in the context of a multi-site study, and make suggestions for improving such protocols based on data acquired during study scanning. Specifically, a mock scanner compliance training protocol was used in a functional imaging study with a group of adolescents and adults with Attention Deficit Hyperactivity Disorder (ADHD) and a matched sample of healthy children and adults. Head motion was measured during mock and actual scanning. Participants across groups exhibited excess motion (>2 mm) on 43% of runs during the mock scanner. During actual scanning, excessive motion was limited to 10% of runs. There was a clear task-correlated head motion during a go/no-go task that occurred even after the compliance training: participants had a tendency to respond with increased head motion immediately after committing an error. This study illustrates the need to (1) report data attrition due to head motion, (2) assess task-related motion, and (3) consider mock scanner training in functional imaging protocols.