Psychiatry Research: Neuroimaging
Volume 156, Issue 3 , Pages 209-215 , 15 December 2007

Corpus callosum abnormalities associated with greater externalizing behaviors in subjects at high risk for alcohol dependence

  • Ganesan Venkatasubramanian

      Affiliations

    • Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029 India
    • Corresponding Author InformationCorresponding author. Tel.: +91 80 26995256; fax: +91 80 26564830.
  • ,
  • George Anthony

      Affiliations

    • Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029 India
  • ,
  • Umesh Srinivasa Reddy

      Affiliations

    • Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India
  • ,
  • Varun Venkatesh Reddy

      Affiliations

    • Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India
  • ,
  • Peruvumba N. Jayakumar

      Affiliations

    • Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India
  • ,
  • Vivek Benegal

      Affiliations

    • Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029 India

Received 5 July 2006 ,Revised 25 October 2006 ,Accepted 25 December 2006.

References 

  1. American Psychiatric Association . DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. 4th ed.. Washington, DC: American Psychiatric Association; 1994;
  2. Annett M. The binomial distribution of right, mixed and left handedness. Quarterly Journal of Experimental Psychology. 1967;19:327–333
  3. Begleiter H, Porjesz B. What is inherited in the predisposition toward alcoholism? A proposed model. Alcoholism: Clinical and Experimental Research. 1999;23:1125–1135
  4. Benegal V, Jain S, Subbakrishna DK, Channabasavanna SM. P300 amplitudes vary inversely with continuum of risk in first degree male relatives of alcoholics. Psychiatric Genetics. 1995;5:149–156
  5. Benegal V, Antony G, Venkatasubramanian G, Jayakumar PN. Gray matter volume abnormalities and externalizing symptoms in subjects at high-risk for alcohol dependence. Addiction Biology. 2007;12:122–132
  6. Buchmann J, Wolters A, Haessler F, Bohne S, Nordbeck R, Kunesch E. Disturbed transcallosally mediated motor inhibition in children with attention deficit hyperactivity disorder (ADHD). Clinical Neurophysiology. 2003;114:2036–2042
  7. Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger JI, et al. A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. Journal of Studies on Alcohol. 1994;55:149–158
  8. Goldstein RZ, Volkow ND. Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. American Journal of Psychiatry. 2002;159:1642–1652
  9. Gorenstein EE, Newman JP. Disinhibitory psychopathology: a new perspective and a model for research. Psychological Review. 1980;87:301–315
  10. Haber JR, Jacob T, Heath AC. Paternal alcoholism and offspring conduct disorder: evidence for the ‘common genes’ hypothesis. Twin Research and Human Genetics. 2005;8:120–131
  11. Hill SY. Trajectories of alcohol use and electrophysiological and morphological indices of brain development: distinguishing causes from consequences. Annals of the New York Academy of Sciences. 2004;1021:245–259
  12. Hill SY, Shen S. Neurodevelopmental patterns of visual P3b in association with familial risk for alcohol dependence and childhood diagnosis. Biological Psychiatry. 2002;51:621–631
  13. Hill SY, De Bellis MD, Keshavan MS, Lowers L, Shen S, Hall J, et al. Right amygdala volume in adolescent/young adult offspring from families at high-risk for developing alcoholism. Biological Psychiatry. 2001;49:894–905
  14. Hoffman LD, Polich J. P300, handedness, and corpus callosal size: gender, modality, and task. International Journal of Psychophysiology. 1999;31:163–174
  15. Karbe H, Herholz K, Halber M, Heiss WD. Collateral inhibition of transcallosal activity facilitates functional brain asymmetry. Journal of Cerebral Blood Flow and Metabolism. 1998;18:1157–1161
  16. Keshavan MS, Anderson S, Beckwith C, Nash K, Pettegrew J, Krishnan KRR. A comparison of stereology and segmentation techniques for volumetric measurements of brain ventricles. Psychiatric Research: Neuroimaging. 1995;61:53–60
  17. Keshavan MS, Diwadkar VA, DeBellis M, Dick E, Kotwal R, Rosenberg DR, et al. Development of the corpus callosum in childhood, adolescence and early adulthood. Life Sciences. 2002;70:1909–1922
  18. Pfefferbaum A, Lim KO, Desmond JE, Sullivan EV. Thinning of the corpus callosum in older alcoholic men: a magnetic resonance imaging study. Alcoholism: Clinical and Experimental Research. 1996;20:752–757
  19. Rohlfing T, Sullivan EV, Pfefferbaum A. Deformation-based brain morphometry to track the course of alcoholism: differences between intra-subject and inter-subject analysis. Psychiatry Research: Neuroimaging. 2006;146:157–170
  20. Schulte T, Pfefferbaum A, Sullivan EV. Parallel interhemispheric processing in aging and alcoholism: relation to corpus callosum size. Neuropsychologia. 2004;42:257–271
  21. Schulte T, Sullivan EV, Muller-Oehring EM, Adalsteinsson E, Pfefferbaum A. Corpus callosal microstructural integrity influences interhemispheric processing: a diffusion tensor imaging study. Cerebral Cortex. 2005;15:1384–1392
  22. Schweinsburg AD, Paulus MP, Barlett VC, Killeen LA, Caldwell LC, Pulido C, et al. An FMRI study of response inhibition in youths with a family history of alcoholism. Annals of the New York Academy of Sciences. 2004;1021:391–394
  23. Seidman LJ, Valera EM, Makris N. Structural brain imaging of attention-deficit/hyperactivity disorder. Biological Psychiatry. 2005;57:1263–1272
  24. Swayze VW, Johnson VP, Hanson JW, Piven J, Sato Y, Giedd JN, et al. Magnetic resonance imaging of brain anomalies in fetal alcohol syndrome. Pediatrics. 1997;99:232–240
  25. Venkatasubramanian G, Jayakumar PN, Gangadhar BN, Janakiramaiah N, Subbakrishna DK, Keshavan MS. Measuring the corpus callosum in schizophrenia: a technique with neuroanatomical and cytoarchitectural basis. Neurology India. 2003;51:189–192
  26. Westerhausen R, Walter C, Kreuder F, Wittling RA, Schweiger E, Wittling E. The influence of handedness and gender on the microstructure of the human corpus callosum: a diffusion-tensor magnetic resonance imaging study. Neuroscience Letters. 2003;351:99–102
  27. Witelson SF. Hand and sex differences in the isthmus and genu of the human corpus callosum. A postmortem morphological study. Brain. 1989;112:799–835
  28. Woodruff P, Pearson G, Geer G, Barta M, Childoat P. A computerized magnetic resonance imaging study of corpus callosum morphology in schizophrenia. Psychological Medicine. 1993;23:45–56

PII: S0925-4927(07)00011-X

doi: 10.1016/j.pscychresns.2006.12.010

Psychiatry Research: Neuroimaging
Volume 156, Issue 3 , Pages 209-215 , 15 December 2007