Psychiatry Research: Neuroimaging
Volume 156, Issue 1 , Pages 69-74 , 15 October 2007

Dopamine D2/D3 receptor binding in the anterior cingulate cortex and executive functioning

  • Ville Lumme

      Affiliations

    • Turku PET Centre, University of Turku, c/o Turku University Central Hospital, PO Box 52, FIN-20521 Turku, Finland
    • Department of Psychiatry, University of Turku, FIN-20520, Turku, Finland
    • ,
  • Sargo Aalto

      Affiliations

    • Department of Psychology, Åbo Akademi University, Turku, Finland
    • Turku PET Centre, University of Turku, c/o Turku University Central Hospital, PO Box 52, FIN-20521 Turku, Finland
    • ,
  • Tuula Ilonen

      Affiliations

    • Department of Psychiatry, University of Turku, FIN-20520, Turku, Finland
    • ,
  • Kjell Någren

      Affiliations

    • Turku PET Centre, University of Turku, c/o Turku University Central Hospital, PO Box 52, FIN-20521 Turku, Finland
    • ,
  • Jarmo Hietala

      Affiliations

    • Turku PET Centre, University of Turku, c/o Turku University Central Hospital, PO Box 52, FIN-20521 Turku, Finland
    • Department of Psychiatry, University of Turku, FIN-20520, Turku, Finland
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, Building 9, FIN-20700 Turku, Finland. Tel.: +358 2 269 2520; fax: +358 2 269 2528.

Received 3 July 2006 ,Revised 22 December 2006 ,Accepted 26 December 2006.

References 

  1. Aalto S, Bruck A, Laine M, Nagren K, Rinne JO. Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: a positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457. Journal of Neuroscience. 2005;25:2471–2477
  2. Buchsbaum BR, Greer S, Chang WL, Berman KF. Meta-analysis of neuroimaging studies of the Wisconsin Card-Sorting Task and component processes. Human Brain Mapping. 2005;25:35–45
  3. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences. 2000;4:215–222
  4. Chou YH, Halldin C, Farde L. Effect of amphetamine on extrastriatal D2 dopamine receptor binding in the primate brain: a PET study. Synapse. 2000;38:138–143
  5. Durstewitz D, Seamans JK. The computational role of dopamine D1 receptors in working memory. Neural Networks. 2002;15:561–572
  6. Everett J, Lavoie K, Gagnon JF, Gosselin N. Performance of patients with schizophrenia on the Wisconsin Card Sorting Test (WCST). Journal of Psychiatry and Neuroscience. 2001;26:123–130
  7. Farde L, Suhara T, Nyberg S, Karlsson P, Nakashima Y, Hietala J, et al. A PET-study of [11C]FLB 457 binding to extrastriatal D2-dopamine receptors in healthy subjects and antipsychotic drug-treated patients. Psychopharmacology. 1997;133:396–404
  8. Friston KJ, Holmes AP, Worsley KJ, Poline J, Frith CD, Frackowiak RSJ. Statistical parametric maps in functional imaging: a general linear approach. Human Brain Mapping. 1994;2:189–210
  9. Glickstein SB, Hof PR, Schmauss C. Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits. Journal of Neuroscience. 2002;22:5619–5629
  10. Goldman-Rakic PS. Regional and cellular fractionation of working memory. Proceedings of the National Academy of Sciences of the United States of America. 1996;93:13473–13480
  11. Goldman-Rakic PS, Muly EC, Williams GV. D1 receptors in prefrontal cells and circuits. Brain Research: Brain Research Reviews. 2000;31:295–301
  12. Gunn RN, Lammertsma AA, Hume SP, Cunningham VJ. Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. NeuroImage. 1997;6:279–287
  13. Hall H, Farde L, Halldin C, Hurd YL, Pauli S, Sedvall G. Autoradiographic localization of extrastriatal D2-dopamine receptors in the human brain using [125I]epidepride. Synapse. 1996;23:115–123
  14. Hall H, Halldin C, Dijkstra D, Wikstrom H, Wise LD, Pugsley TA, et al. Autoradiographic localisation of D3-dopamine receptors in the human brain using the selective D3-dopamine receptor agonist (+)-[3H]PD 128907. Psychopharmacology. 1996;128:240–247
  15. Heaton RK, Chelune GJ, Talley JL, Kay GG, Curtiss G. Wisconsin Card Sorting Test Manual. Odessa, FL: Psychological Assessment Resources; 1993;
  16. Kaasinen V, Nagren K, Hietala J, Farde L, Rinne JO. Sex differences in extrastriatal dopamine D2-like receptors in the human brain. American Journal of Psychiatry. 2001;158:308–311
  17. Kaasinen V, Vilkman H, Hietala J, Nagren K, Helenius H, Olsson H, et al. Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain. Neurobiology of Aging. 2000;21:683–688
  18. Kellendonk C, Simpson EH, Polan HJ, Malleret G, Vronskaya S, Winiger V, et al. Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning. Neuron. 2006;49:603–615
  19. Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. NeuroImage. 1996;4:153–158
  20. Laruelle M. Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review. Journal of Cerebral Blood Flow and Metabolism. 2000;20:423–451
  21. Lie CH, Specht K, Marshall JC, Fink GR. Using fMRI to decompose the neural processes underlying the Wisconsin Card Sorting Test. NeuroImage. 2006;30:1038–1049
  22. MacDonald AW, Cohen JD, Stenger VA, Carter CS. Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science. 2000;288:1835–1838
  23. Muller U, von Cramon DY, Pollmann S. D1- versus D2-receptor modulation of visuospatial working memory in humans. Journal of Neuroscience. 1998;18:2720–2728
  24. Nieoullon A. Dopamine and the regulation of cognition and attention. Progress in Neurobiology. 2002;67:53–83
  25. Olsson H, Halldin C, Farde L. Differentiation of extrastriatal dopamine D2 receptor density and affinity in the human brain using PET. NeuroImage. 2004;22:794–803
  26. Reeves SJ, Grasby PM, Howard RJ, Bantick RA, Asselin MC, Mehta MA. A positron emission tomography (PET) investigation of the role of striatal dopamine (D2) receptor availability in spatial cognition. NeuroImage. 2005;28:216–226
  27. Seamans JK, Yang CR. The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Progress in Neurobiology. 2004;74:1–58
  28. Seamans JK, Gorelova N, Durstewitz D, Yang CR. Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons. Journal of Neuroscience. 2001;21:3628–3638
  29. Sudo Y, Suhara T, Inoue M, Ito H, Suzuki K, Saijo T, et al. Reproducibility of [11C]FLB 457 binding in extrastriatal regions. Nuclear Medicine Communications. 2001;22:1215–1221
  30. Suzuki M, Hurd YL, Sokoloff P, Schwartz JC, Sedvall G. D3 dopamine receptor mRNA is widely expressed in the human brain. Brain Research. 1998;779:58–74
  31. Szekeres G, Keri S, Juhasz A, Rimanoczy A, Szendi I, Czimmer C, et al. Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2004;124:1–5
  32. Tsukada H, Nishiyama S, Fukumoto D, Sato K, Kakiuchi T, Domino EF. Chronic NMDA antagonism impairs working memory, decreases extracellular dopamine, and increases D1 receptor binding in prefrontal cortex of conscious monkeys. Neuropsychopharmacology. 2005;30:1861–1869
  33. Vilkman H, Kajander J, Nagren K, Oikonen V, Syvalahti E, Hietala J. Measurement of extrastriatal D2-like receptor binding with [11C]FLB 457—a test–retest analysis. European Journal of Nuclear Medicine. 2000;27:1666–1673
  34. Volkow ND, Gur RC, Wang GJ, Fowler JS, Moberg PJ, Ding YS, et al. Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals. American Journal of Psychiatry. 1998;155:344–349
  35. Wang M, Vijayraghavan S, Goldman-Rakic PS. Selective D2 receptor actions on the functional circuitry of working memory. Science. 2004;303:853–856

☆ This work was done in the Department of Psychiatry and Turku PET Centre, University of Turku, Turku, Finland.

PII: S0925-4927(07)00010-8

doi: 10.1016/j.pscychresns.2006.12.012

Psychiatry Research: Neuroimaging
Volume 156, Issue 1 , Pages 69-74 , 15 October 2007

Article Tools

* Image Usage & Resolution