Psychiatry Research: Neuroimaging
Volume 155, Issue 1 , Pages 29-44 , 15 May 2007

Fronto-limbic and autonomic disjunctions to negative emotion distinguish schizophrenia subtypes

  • Leanne (Lea) M. Williams

      Affiliations

    • Brain Dynamics Centre, Westmead Hospital, NSW, 2145, Australia
    • Psychological Medicine, University of Sydney, Australia
    • Corresponding Author InformationCorresponding author. Brain Dynamics Centre, Acacia House, Westmead Hospital, Westmead NSW, 2145, Australia.
    • ,
  • Pritha Das

      Affiliations

    • Brain Dynamics Centre, Westmead Hospital, NSW, 2145, Australia
    • Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD), Sydney, Australia
    • ,
  • Belinda J. Liddell

      Affiliations

    • Brain Dynamics Centre, Westmead Hospital, NSW, 2145, Australia
    • Psychological Medicine, University of Sydney, Australia
    • ,
  • Gloria Olivieri

      Affiliations

    • Brain Dynamics Centre, Westmead Hospital, NSW, 2145, Australia
    • MRI Unit, Westmead Hospital, NSW, 2145, Australia
    • ,
  • Anthony S. Peduto

      Affiliations

    • Brain Dynamics Centre, Westmead Hospital, NSW, 2145, Australia
    • MRI Unit, Westmead Hospital, NSW, 2145, Australia
    • ,
  • Anthony S. David

      Affiliations

    • Institute of Psychiatry, Kings College London, SE5 8AF, UK
    • ,
  • Evian Gordon

      Affiliations

    • Brain Dynamics Centre, Westmead Hospital, NSW, 2145, Australia
    • Psychological Medicine, University of Sydney, Australia
    • ,
  • Anthony W.F. Harris

      Affiliations

    • Brain Dynamics Centre, Westmead Hospital, NSW, 2145, Australia
    • Psychological Medicine, University of Sydney, Australia

Received 25 May 2006 ,Revised 8 November 2006 ,Accepted 25 December 2006.

References 

  1. Bernstein AS, Frith CD, Gruzelier JH, Patterson T, Straube E, Venables PH, et al. An analysis of the skin conductance orienting response in samples of American, British and German schizophrenics. Biological Psychology. 1982;14:155–211
  2. In:  Bezchlibnyk-Butler KZ,  Jeffries JJ editor. Clinical Handbook of Psychotropic drugs. 13th edition. Hogrefe & Huber; 2003;
  3. Birchwood M, Smith J, Cochrane R, Wetton S, Copestake S. The Social Functioning Scale. The development and validation of a new scale of social adjustment for use in family intervention programmes with schizophrenic patients. British Journal of Psychiatry. 1990;157:853–859
  4. Blair RJR, Morris JS, Frith CD, Perrett DI, Dolan RJ. Dissociable neural responses to facial expressions of sadness and anger. Brain. 1999;122:883–893
  5. Brammer M, Bullmore ET, Simmons A, Williams SCR, Grasby PM, Howard RJ, et al. Generic brain activation mapping in functional magnetic resonance imaging: a non parametric approach. Magnetic Resonance Imaging. 1997;15:763–770
  6. Bullmore ET, Brammer MJ, Williams SCR, Rabe-Hesketh S, Janot N, David AS, et al. Statistical methods of estimation and inference for functional MR image analysis. Magnetic Resonance in Medicine. 1996;35:261–277
  7. Bullmore ET, Suckling J, Overmeyer S, Rabe-Hesketh S, Taylor E, Brammer MJ. Global, voxel and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain. IEEE Transactions on Medical Imaging. 1999;18:32–42
  8. Bullmore ET, Long C, Suckling J, Fadili J, Calvert GA, Zelaya F, et al. Coloured noise and computational inference in neurophysiological (fMRI) time series analysis: resampling methods in time and wavelet domains. Human Brain Mapping. 2001;12:61–78
  9. Calder AJ, Young A, Rowland D, Perrett D. Computer-enhanced emotion in facial expressions. Proceedings of the Royal Society London. 1997;264B:919–925
  10. Damasio AR. The somatic marker hypothesis and the possible functions of the prefrontal cortex. Philosophical Transactions of the Royal Society London B. 1996;351:1413–1420
  11. Das P., Kemp A.H., Flynn G., Harris A.W.F., Liddell B.J., Whitford T., Peduto A.S., Gordon E., Williams L.M., in press. Functional disconnections in the direct and indirect amygdala pathways for fear processing in schizophrenia. Schizophrenia Research.
  12. David A. Insight and psychosis. British Journal of Psychiatry. 1990;156:798–808
  13. David A, Buchanan A, Reed A, Almeida O. The assessment of insight in psychosis. British Journal of Psychiatry. 1992;161:599–602
  14. Dawson ME, Schell AM. What does electrodermal activity tell us about prognosis in schizophrenia spectrum?. Schizophrenia Research. 2002;54:87–93
  15. Dawson ME, Nuechterlein KH, Schell AM, Gitlin M, Ventura J. Autonomic abnormalities in schizophrenia: state or trait indicator?. Archives of General Psychiatry. 1994;51:813–824
  16. Edwards J, Jackson JH, Pattison PE. Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review. Clinical Psychology Review. 2002;22:789–832
  17. Ekman P, Friesen WV, Ellsworth P. Emotion in the Human Face. New York: Pergamon; 1972;
  18. Fahim C, Stip E, Mancini-Marie A, Mensour B, Boulay LJ, Leroux JM, et al. Brain activity during emotionally negative pictures in schizophrenia with and without flat affect: an fMRI study. Psychiatry Research. 2005;140:1–15
  19. Green MJ, Williams LM, Davidson D. Visual scanpaths and facial affect recognition in delusion-prone individuals: increased sensitivity to threat?. Cognitive Neuropsychiatry. 2003;8:19–41
  20. Gruzelier JH, Venables PH. Skin conductance orienting activity in a heterogenous sample of schizophrenics: possible evidence of limbic dysfunction. Journal of Nervous and Mental Disease. 1972;155:277–287
  21. Gur RE, McGrath C, Chan RM, Lee S, Turner T, Turetsky BI, et al. An fMRI study of facial emotion processing in patients with schizophrenia. American Journal of Psychiatry. 2002;159:1992–1999
  22. Karakula H, Grzywa A. Dimensions of psychopathology in paranoid schizophrenia. European Archives of Psychiatry and Clinical Neuroscience. 1999;249:247–255
  23. Kay SR, Opler LA, Fiszbein A. Positive and Negative Syndrome Scale (PANSS). North Tonawanda, NY: Multi-Health Systems Inc.; 1986;
  24. Keltner D, Kring AM. Emotion, social function, and psychopathology. Review of General Psychology. 1998;2:320–342
  25. Kemp R, David A. Insight and compliance. In:  Blackwell B editors. Compliance and the Treatment Alliance in Serious Mental Illness. Amsterdam: Harwood Academic Publishers; 1997;p. 61–86
  26. Kim KI, Li D, Jiang Z, Cui X, Lin L, Kang JJ, et al. Schizophrenic delusions among Koreans, Korean-Chinese and Chinese: a transcultural study. International Journal of Social Psychiatry. 1993;39:190–199
  27. Koren D, Seidman LJ, Goldsmith M, Harvey PD. Real-world cognitive – and metacognitive – dysfunction in schizophrenia: a new approach for measuring (and remediating) more “right stuff”. Schizophrenia Bulletin. 2006;32:310–326
  28. Kring AM, Neale JM. Do schizophrenics show a disjunctive relationship among expressive, experiential and psychophysiological components of emotion?. Journal of Abnormal Psychology. 1996;105:249–257
  29. Kring, A.M., Earnst, K.S., Germans, M.K. 1999. Microexpressive facial activity and psychophysiological deficits in schizophrenia. Unpublished manuscript, University of California, Berkeley.
  30. Lim CL, Rennie C, Barry JR, Bahramali H, Lazzaro I, Manor B, et al. Decomposing skin conductance into tonic and phasic components. International Journal of Psychophysiology. 1997;25:97–109
  31. Lim CL, Gordon E, Harris AWF, Bahramali H, Li WM, Manor BR, et al. Electrodermal activity in schizophrenia: a quantitative study using a short interstimulus paradigm. Biological Psychiatry. 1999;45:127–135
  32. Loughland CM, Williams LM, Gordon E. Visual scanpaths and facial expressions of emotion in an outpatient schizophrenia sample. Schizophrenia Research. 2002;55:159–170
  33. Mandal MK, Pandey R, Prasad AB. Facial expressions of emotion and schizophrenia: a review. Schizophrenia Bulletin. 1998;24:399–412
  34. Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. American Journal of Psychiatry. 1999;156:675–682
  35. McEvoy JP, Freter S, Everett G, Geller GL, Appelbaum P, Apperson LJ, et al. Insight and the clinical outcome of schizophrenic patients. Journal of Nervous and Mental Disease. 1989;177:48–51
  36. Nelson HE, O'Connell A. Dementia: the estimation of premorbid intelligence levels using the New Adult Reading Test. Cortex. 1978;14:234–244
  37. Öhman A, Öhlund LS, Alm T, Wieselgren LM, Öst LG, Lindström LH. Electrodermal nonresponding, premorbid adjustment, and symptomatology as predictors of long-term social functioning in schizophrenia. Journal of Abnormal Psychology. 1989;98:426–435
  38. Parrish TB, Gitelman DR, LaBar KS, Mesulam M-M. Impact of signal-to-noise on functional MRI. Magnetic Resonance in Medicine. 2000;44:925–932
  39. Phan KL, Wager T, Taylor SF, Liberzon I. Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. NeuroImage. 2002;16:331–348
  40. Phillips ML, Young AW, Senior C, Calder AJ, Rowland D, Brammer M, et al. A specific neural substrate for perceiving facial expression of disgust. Nature. 1997;389:495–498
  41. Phillips ML, Senior C, Fahy T, David AS. Disgust—the forgotten emotion of psychiatry. British Journal of Psychiatry. 1998;172:373–375
  42. Phillips ML, Williams LM, Senior C, Bullmore ET, Brammer MJ, Andrew C, et al. A distinction between paranoid and non-paranoid schizophrenics on the basis of their neural response to negative facial expressions. Psychiatry Research Neuroimaging. 1999;92:11–31
  43. Phillips ML, Senior C, David AS. Perception of threat in schizophrenics with persecutory delusions: an investigation using visual scan paths. Psychological Medicine. 2000;30:157–167
  44. Raine A, Venables PH, Mednick S, Mellingen K. Increased psychophysiological arousal and orienting at ages 3 and 11 years in persistently schizotypal adults. Schizophrenia Research. 2002;54:77–85
  45. Robins LN, Wing J, Wittchen H-U, Helzer JE, Babor TF, Burke J, et al. The Composite International Diagnostic Interview. Archives of General Psychiatry. 1998;45:1069–1077
  46. Schell AM, Dawson ME, Nuechterlein KH, Subotnik K, Ventura J. The temporal stability of electrodermal variables over a one-year period in patients with recent-onset schizophrenia and in normal subjects. Psychophysiology. 2002;39:124–132
  47. Streit M, Wolwer W, Gaebel W. Facial-affect recognition and visual scanning behaviour in the course of schizophrenia. Schizophrenia Research. 1997;24:311–317
  48. Surguladze S, Russell T, Kucharska-Pietura K, Travis MJ, Giampietro V, David AS, et al. A reversal of the normal pattern of parahippocampal response to neutral and fearful faces is associated with reality distortion in schizophrenia. Biological Psychiatry. 2006;60:423–431
  49. Talairach J, Tournoux P. Co-planar Sterotactic Atlas of the Human Brain. Stuttgart: Thieme; 1988;
  50. Wild B, Erb M, Bartels M. Are emotions contagious? Evoked emotions while viewing emotionally expressive faces: quality, quantity, time course and gender differences. Psychiatry Research. 2001;102:109–124
  51. Williams LM, Gordon E, Bahramali H, Wright JJ, Meares RA. Late component ERPs are associated with distinct schizophrenia syndromes. International Journal of Neuroscience. 2000;105:37–52
  52. Williams LM, Phillips ML, Brammer MJ, Skerrett D, Lagopoulos J, Rennie C, et al. Arousal dissociates amygdale and hippocampal fear responses: evidence from simultaneous fMRI and skin conductance recording. NeuroImage. 2001;14:1070–1079
  53. Williams LM, Brown KJ, Das P, Brammer MJ, Boucsein B, Sokolov EN, et al. The dynamics of cortico-amygdala and autonomic activity over the experimental time course of fear perception. Cognitive Brain Research. 2004;21:114–123
  54. Williams LM, Das P, Harris A, Liddell B, Brammer MJ, Olivieri G, et al. Dysregulation of arousal and amygdale-prefrontal systems in paranoid schizophrenia. American Journal of Psychiatry. 2004;161:1–10
  55. Williams LM, Das P, Liddell BJ, Olivieri G, Peduto AS, Brammer MJ, et al. BOLD, sweat and fears: functional BOLD, sweat and fears: fMRI and skin conductance distinguish facial fear signals. NeuroReport. 2005;19(1):49–52
  56. Williams LM, Barton MJ, Kemp AH, Liddell BJ, Peduto AP, Gordon E, et al. Distinct amygdala-autonomic arousal profiles in response to fear signals in healthy males and females. NeuroImage. 2005;28:618–626
  57. Zalewski C, Johnson-Selfridge MT, Ohriner S, Zarrella K, Seltzer JC. A review of neuropsychological differences between paranoid and nonparanoid schizophrenia patients. Schizophrenia Bulletin. 1998;24:127–145
  58. Zureick JL, Meltzer HY. Platelet MAO activity in hallucinating and paranoid schizophrenics: a review and meta-analysis. Biological Psychiatry. 1988;24:63–78

PII: S0925-4927(07)00008-X

doi: 10.1016/j.pscychresns.2006.12.018

Psychiatry Research: Neuroimaging
Volume 155, Issue 1 , Pages 29-44 , 15 May 2007

Article Tools

* Image Usage & Resolution