Psychiatry Research: Neuroimaging
Volume 155, Issue 1 , Pages 83-88 , 15 May 2007

A preliminary fMRI study of the effects on cortical activation of the treatment of refractory auditory hallucinations with rTMS

  • Paul B. Fitzgerald

      Affiliations

    • Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Rd, Melbourne, Victoria 3004, Australia
    • Corresponding Author InformationCorresponding author. Alfred Psychiatry Research Centre, First Floor, Old Baker Building, The Alfred, Commercial Rd, Melbourne, Victoria 3004, Australia. Tel.: +61 3 9276 6552; fax: +61 3 9276 6588.
    • ,
  • Anusha Sritharan

      Affiliations

    • Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Rd, Melbourne, Victoria 3004, Australia
    • ,
  • Jessica Benitez

      Affiliations

    • Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Rd, Melbourne, Victoria 3004, Australia
    • ,
  • Z. Jeff Daskalakis

      Affiliations

    • Centre for Addiction and Mental HealthClarke Division, Toronto, Ontario, Canada
    • ,
  • Graeme Jackson

      Affiliations

    • Brain Research Institute, Austin Health and the University of Melbourne, Australia
    • ,
  • Jayashri Kulkarni

      Affiliations

    • Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Rd, Melbourne, Victoria 3004, Australia
    • ,
  • Gary F. Egan

      Affiliations

    • Howard Florey Institute, The University of Melbourne, Victoria, Australia

Received 24 April 2006 ,Revised 25 October 2006 ,Accepted 24 December 2006.

References 

  1. Brunelin J, Poulet E, Bediou B, Kallel L, Dalery J, D'Amato T, et al. Low frequency repetitive transcranial magnetic stimulation improves source monitoring deficit in hallucinating patients with schizophrenia. Schizophrenia Research. 2006;81:41–45
  2. Chen R, Claussen J, Gerloff C. Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology. 1997;48:1398–1403
  3. Copolov DL, Seal ML, Maruff P, Ulusoy R, Wong MT, Tochon-Danguy HJ, et al. Cortical activation associated with the experience of auditory hallucinations and perception of human speech in schizophrenia: a PET correlation study. Psychiatry Research. Neuroimaging. 2003;122:139–152
  4. Cuenod CA, Bookheimer SY, Hertz-Pannier L, Zeffiro TA, Theodore WH, Le Bihan D. Functional MRI during word generation, using conventional equipment: a potential tool for language localization in the clinical environment. Neurology. 1995;45:1821–1827
  5. Fitzgerald PB, Benitez J, Daskalakis JZ, Brown TL, Marston NA, de Castella A, et al. A double-blind sham-controlled trial of repetitive transcranial magnetic stimulation in the treatment of refractory auditory hallucinations. Journal of Clinical Psychopharmacology. 2005;25:358–362
  6. Fitzgerald PB, Benitez J, Oxley T, Daskalakis JZ, de Castella AR, Kulkarni J. A study of the effects of lorazepam and dextromethorphan on the response to cortical 1 Hz repetitive transcranial magnetic stimulation. Neuroreport. 2005;16:1525–1528
  7. Ford JM, Mathalon DH. Corollary discharge dysfunction in schizophrenia: can it explain auditory hallucinations?. International Journal of Psychophysiology. 2005;58:179–189
  8. Friedman L, Kenny JT, Wise AL, Wu D, Stuve TA, Miller DA, et al. Brain activation during silent word generation evaluated with functional MRI. Brain and Language. 1998;64:231–256
  9. Haddock G, McCarron J, Tarrier N, Faragher EB. Scales to measure the dimensions of hallucinations and delusions: the psychotic symptom rating scales (PSYRATS). Psychological Medicine. 1999;29:879–889
  10. Hoffman RE, Rapaport J, Mazure CM, Quinlan DM. Selective speech perception alterations in schizophrenic patients reporting hallucinated “voices”. American Journal of Psychiatry. 1999;156:393–399
  11. Hoffman RE, Hawkins KA, Gueorguieva R, Boutros NN, Rachid F, Carroll K, et al. Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations. Archives of General Psychiatry. 2003;60:49–56
  12. Hoffman RE, Gueorguieva R, Hawkins KA, Varanko M, Boutros NN, Wu YT, et al. Temporoparietal transcranial magnetic stimulation for auditory hallucinations: safety, efficacy and moderators in a fifty patient sample. Biological Psychiatry. 2005;58:97–104
  13. Homan RW, Herman J, Purdy P. Cerebral location of international 10–20 system electrode placement. Electroencephalography and Clinical Neurophysiology. 1987;66:376–382
  14. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  15. Lee SH, Kim W, Chung YC, Jung KH, Bahk WM, Jun TY, et al. A double blind study showing that two weeks of daily repetitive TMS over the left or right temporoparietal cortex reduces symptoms in patients with schizophrenia who are having treatment-refractory auditory hallucinations. Neuroscience Letters. 2005;376:177–181
  16. Li G, Liu HL, Cheung RT, Hung YC, Wong KK, Shen GG, et al. An fMRI study comparing brain activation between word generation and electrical stimulation of language-implicated acupoints. Human Brain Mapping. 2003;18:233–238
  17. Lurito JT, Kareken DA, Lowe MJ, Chen SH, Mathews VP. Comparison of rhyming and word generation with FMRI. Human Brain Mapping. 2000;10:99–106
  18. McIntosh AM, Semple D, Tasker K, Harrison LK, Owens DG, Johnstone EC, et al. Transcranial magnetic stimulation for auditory hallucinations in schizophrenia. Psychiatry Research. Neuroimaging. 2004;127:9–17
  19. Poulet E, Brunelin J, Bediou B, Bation R, Forgeard L, Dalery J, et al. Slow transcranial magnetic stimulation can rapidly reduce resistant auditory hallucinations in schizophrenia. Biological Psychiatry. 2005;57:188–191
  20. Shergill SS, Bullmore E, Simmons A, Murray R, McGuire P. Functional anatomy of auditory verbal imagery in schizophrenic patients with auditory hallucinations. American Journal of Psychiatry. 2000;157:1691–1693
  21. Waters FA, Badcock JC, Maybery MT, Michie PT. Inhibition in schizophrenia: association with auditory hallucinations. Schizophrenia Research. 2003;62:275–280
  22. Woodruff PW, Wright IC, Bullmore ET, Brammer M, Howard RJ, Williams SC, et al. Auditory hallucinations and the temporal cortical response to speech in schizophrenia: a functional magnetic resonance imaging study. American Journal of Psychiatry. 1997;154:1676–1682

PII: S0925-4927(07)00005-4

doi: 10.1016/j.pscychresns.2006.12.011

Psychiatry Research: Neuroimaging
Volume 155, Issue 1 , Pages 83-88 , 15 May 2007

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