Psychiatry Research: Neuroimaging
Volume 155, Issue 1 , Pages 83-88, 15 May 2007

A preliminary fMRI study of the effects on cortical activation of the treatment of refractory auditory hallucinations with rTMS

  • Paul B. Fitzgerald

      Affiliations

    • Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Rd, Melbourne, Victoria 3004, Australia
    • Corresponding Author InformationCorresponding author. Alfred Psychiatry Research Centre, First Floor, Old Baker Building, The Alfred, Commercial Rd, Melbourne, Victoria 3004, Australia. Tel.: +61 3 9276 6552; fax: +61 3 9276 6588.
    • ,
  • Anusha Sritharan

      Affiliations

    • Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Rd, Melbourne, Victoria 3004, Australia
    • ,
  • Jessica Benitez

      Affiliations

    • Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Rd, Melbourne, Victoria 3004, Australia
    • ,
  • Z. Jeff Daskalakis

      Affiliations

    • Centre for Addiction and Mental HealthClarke Division, Toronto, Ontario, Canada
    • ,
  • Graeme Jackson

      Affiliations

    • Brain Research Institute, Austin Health and the University of Melbourne, Australia
    • ,
  • Jayashri Kulkarni

      Affiliations

    • Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Rd, Melbourne, Victoria 3004, Australia
    • ,
  • Gary F. Egan

      Affiliations

    • Howard Florey Institute, The University of Melbourne, Victoria, Australia

Received 24 April 2006; received in revised form 25 October 2006; accepted 24 December 2006.

Abstract 

Three patients underwent fMRI during a word generation task before and after successful treatment of auditory hallucinations with rTMS and were compared to four control subjects. There was a significant increase and more normal task related brain activation in brain areas involved in language processing including left temporoparietal cortex after rTMS treatment.

Keywords: Hallucinations, Schizophrenia, Transcranial Magnetic stimulation, Functional magnetic resonance imaging

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PII: S0925-4927(07)00005-4

doi:10.1016/j.pscychresns.2006.12.011

Psychiatry Research: Neuroimaging
Volume 155, Issue 1 , Pages 83-88, 15 May 2007

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