Psychiatry Research: Neuroimaging
Volume 155, Issue 2 , Pages 167-171 , 15 July 2007

FDG-PET and CSF phospho-tau for prediction of cognitive decline in mild cognitive impairment

  • Andreas Fellgiebel

      Affiliations

    • Department of Psychiatry, University of Mainz, Mainz, Germany
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, University Hospital of Mainz, Untere Zahlbacher Str. 8, 55131 Mainz, Germany. Tel.: +49 6131 172525; fax: +49 6131 176690.
    • ,
  • Armin Scheurich

      Affiliations

    • Department of Psychiatry, University of Mainz, Mainz, Germany
    • ,
  • Peter Bartenstein

      Affiliations

    • Department of Nuclear Medicine, University of Mainz, Mainz, Germany
    • ,
  • Matthias J Müller

      Affiliations

    • Department of Psychiatry, University of Mainz, Mainz, Germany

Received 7 May 2006 ,Revised 2 October 2006 ,Accepted 6 December 2006.

References 

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  4. De Leon MJ, DeSanti S, Zinkowski R, Mehta PD, Pratico D, Segal S, et al. Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiology of Aging. 2006;27:394–401
  5. Desgranges B, Baron JC, Lalevee C, Giffard B, Viader F, de La Sayette V, et al. The neural substrates of episodic memory impairment in Alzheimer's disease as revealed by FDG-PET: relationship to degree of deterioration. Brain. 2002;125:1116–1124
  6. Drzezga A, Lautenschlager N, Siebner H, Riemenschneider M, Willoch F, Minoshima S, et al. Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study. European Journal of Nuclear Medicine and Molecular Imaging. 2003;30:1104–1113
  7. Fellgiebel A, Siessmeier T, Scheurich A, Winterer G, Bartenstein P, Schmidt LG, et al. Association of elevated phospho-tau levels with Alzheimer-typical 18F-fluoro-2-deoxy-d-glucose positron emission tomography findings in patients with mild cognitive impairment. Biological Psychiatry. 2004;56:279–283
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  9. Herholz K, Salmon E, Perani D, Baron JC, Holthoff V, Frölich L, et al. Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage. 2002;17:302–316
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  12. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Archives of Neurology. 1999;56:303–308
  13. Schönheit B, Zarski R, Ohm TG. Spatial and temporal relationships between plaques and tangles in Alzheimer-pathology. Neurobiology of Aging. 2004;25:697–711
  14. Tabert MH, Manly JJ, Liu X, Pelton GH, Rosenblum S, Jacobs M, et al. Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment. Archives of General Psychiatry. 2006;63:916–924

PII: S0925-4927(06)00227-7

doi: 10.1016/j.pscychresns.2006.12.002

Psychiatry Research: Neuroimaging
Volume 155, Issue 2 , Pages 167-171 , 15 July 2007

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