Psychiatry Research: Neuroimaging
Volume 155, Issue 2 , Pages 167-171, 15 July 2007

FDG-PET and CSF phospho-tau for prediction of cognitive decline in mild cognitive impairment

  • Andreas Fellgiebel

      Affiliations

    • Department of Psychiatry, University of Mainz, Mainz, Germany
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, University Hospital of Mainz, Untere Zahlbacher Str. 8, 55131 Mainz, Germany. Tel.: +49 6131 172525; fax: +49 6131 176690.
    • ,
  • Armin Scheurich

      Affiliations

    • Department of Psychiatry, University of Mainz, Mainz, Germany
    • ,
  • Peter Bartenstein

      Affiliations

    • Department of Nuclear Medicine, University of Mainz, Mainz, Germany
    • ,
  • Matthias J Müller

      Affiliations

    • Department of Psychiatry, University of Mainz, Mainz, Germany

Received 7 May 2006; received in revised form 2 October 2006; accepted 6 December 2006.

Abstract 

Specific patterns of cortical glucose metabolism disturbances and increased CSF phospho-tau (p-tau181) concentrations could be demonstrated to predict cognitive decline and shift to dementia in amnestic mild cognitive impairment (MCI). But comparisons of both diagnostic tools have not been undertaken so far. The aim of the study was to compare 18F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) findings and CSF phospho-tau (p-tau181) measurements in the prediction of cognitive deterioration and conversion to dementia in MCI. During follow-up (mean 19 months) eight of 16 patients (50%) showed progressive cognitive decline, and four patients shifted to dementia. Pathological FDG-PET and elevated p-tau181 levels both predicted deterioration. While p-tau181 was highly sensitive for cognitive decline, FDG-PET was superior in predicting conversion to clinical dementia in MCI patients.

Keywords: MCI, Prediction, Conversion to dementia, FDG-PET, Phospho-tau, Cognitive decline

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PII: S0925-4927(06)00227-7

doi:10.1016/j.pscychresns.2006.12.002

Psychiatry Research: Neuroimaging
Volume 155, Issue 2 , Pages 167-171, 15 July 2007

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