Psychiatry Research: Neuroimaging
Volume 155, Issue 3 , Pages 245-256 , 15 August 2007

HPA axis dysfunction in unmedicated major depressive disorder and its normalization by pharmacotherapy correlates with alteration of neural activity in prefrontal cortex and limbic/paralimbic regions

  • Masako Aihara

      Affiliations

    • Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Maebashi, Japan
    • ,
  • Itsuro Ida

      Affiliations

    • Department of Neuropsychiatry, National Takasaki Hospital, 36 Takamatsu-cho, Takasaki, Gunma 370-0829, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 27 322 5901; fax: +81 27 327 1826.
    • ,
  • Naoya Yuuki

      Affiliations

    • Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Maebashi, Japan
    • ,
  • Akihiko Oshima

      Affiliations

    • Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Maebashi, Japan
    • ,
  • Hiroshi Kumano

      Affiliations

    • Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Maebashi, Japan
    • ,
  • Keisuke Takahashi

      Affiliations

    • Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Maebashi, Japan
    • ,
  • Masato Fukuda

      Affiliations

    • Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Maebashi, Japan
    • ,
  • Noboru Oriuchi

      Affiliations

    • Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan
    • ,
  • Keigo Endo

      Affiliations

    • Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan
    • ,
  • Hiroshi Matsuda

      Affiliations

    • Department of Nuclear Medicine, Saitama Medical School Hospital, Iruma, Japan
    • ,
  • Masahiko Mikuni

      Affiliations

    • Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Maebashi, Japan

Received 5 March 2006 ,Revised 7 July 2006 ,Accepted 26 November 2006.

References 

  1. Attar-Levy D, Martinot JL, Blin J, Dao-Castellana MH, Crouzel C, Mazoyer B, et al. The cortical serotonin2 receptors studied with positron-emission tomography and [18F]-setoperone during depressive illness and antidepressant treatment with clomipramine. Biological Psychiatry. 1999;45:180–186
  2. Biver F, Goldman S, Delvenne V, Luxen A, De Maertelaer V, Hubain P, et al. Frontal and parietal metabolic disturbances in unipolar depression. Biological Psychiatry. 1994;36:381–388
  3. Brady LS, Whitfield HJ, Fox RJ, Gold PW, Herkenham M. Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications. Journal of Clinical Investigation. 1991;87:831–837
  4. Brody AL, Saxena S, Silverman DH, Alborzian S, Fairbanks LA, Phelps ME, et al. Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine. Psychiatry Research: Neuroimaging. 1999;91:127–139
  5. Buchsbaum MS, Wu J, Siegel BV, Hacket E, Trenary M, Abel L, et al. Effect of sertraline on regional metabolic rate in patients with affective disorder. Biological Psychiatry. 1997;41:15–22
  6. Carroll BJ, Feinberg M, Greden JF, Tarika J, Albala AA, Haskett RF, et al. A specific laboratory test for the diagnosis of melancholia. Standardization, validation, and clinical utility. Archives of General Psychiatry. 1981;38:15–22
  7. Diorio D, Viau V, Meaney MJ. The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress. Journal of Neuroscience. 1993;13:3839–3847
  8. Drevets WC, Raichle ME. Neuroanatomical circuits in depression: implications for treatment mechanisms. Psychopharmacology Bulletin. 1992;28:261–274
  9. Drevets WC, Videen TO, Price JL, Preskorn SH, Carmichael ST, Raichle ME. A functional anatomical study of unipolar depression. Journal of Neuroscience. 1992;12:3628–3641
  10. Drevets WC, Price JL, Bardgett ME, Reich T, Todd RD, Raichle ME. Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels. Pharmacology, Biochemistry and Behavior. 2002;71:431–447
  11. Drevets WC, Bogers W, Raichle ME. Functional anatomical correlates of antidepressant drug assessed using PET measures of regional glucose metabolism. European Psychopharmacology. 2002;12:527–544
  12. Figueiredo HF, Bodie BL, Tauchi M, Dolgas CM, Herman JP. Stress integration after acute and chronic predator stress: differential activation of central stress circuitry and sensitization of the hypothalamic-pituitary-adrenocortical axis. Endocrinology. 2003;144:5249–5258
  13. Figueiredo HF, Bruestle A, Bodie BL, Dolgas CM, Herman JP. The medial prefrontal cortex differentially regulates stress-induced c-fos expression in the forebrain depending on type of stressor. European Journal of Neuroscience. 2003;18:2357–2364
  14. Gerrits M, Westenbroek C, Fokkema DS, Jongsma ME, Den Boer JA, Ter Horst GJ. Increased stress vulnerability after a prefrontal cortex lesion in female rats. Brain Research Bulletin. 2003;61:627–635
  15. Halbreich U, Asnis GM, Shindledecker R, Zumoff B, Nathan RS. Cortisol secretion in endogenous depression. I. Basal plasma levels. Archives of General Psychiatry. 1985;42:904–908
  16. Herman JP, Schafer MK, Young EA, Thompson R, Douglass J, Akil H, et al. Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis. Journal of Neuroscience. 1989;9:3072–3082
  17. Heuser I, Yassouridis A, Holsboer F. The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. Journal of Psychiatric Research. 1994;28:341–356
  18. Holsboer F, von Bardeleben U, Wiedemann K, Müller OA, Stalla GK. Serial assessment of corticotropin-releasing hormone response after dexamethasone in depression. Implications for pathophysiology of DST non-suppression. Biological Psychiatry. 1987;22:228–234
  19. Holsboer F, Lauer CJ, Schreiber W, Krieg JC. Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders. Neuroendocrinology. 1995;62:340–347
  20. Hurley KM, Herbert H, Moga MM, Saper CB. Efferent projections of the infralimbic cortex of the rat. Journal of Comparative Neurology. 1991;308:249–276
  21. Kennedy SH, Evans KR, Krüger S, Mayberg HS, Meyer JH, McCann S, et al. Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression. American Journal of Psychiatry. 2001;158:899–905
  22. Kunugi H, Ida I, Owashi T, Kimura M, Inoue Y, Nakagawa S, et al. Assessment of the dexamethasone/CRH test as a state-dependent marker for hypothalamic-pituitary-adrenal (HPA) axis abnormalities in major depressive episode: a multicenter study. Neuropsychopharmacology. 2006;31:212–220
  23. Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. American Journal of Psychiatry. 1999;156:675–682
  24. Mayberg HS, Brannan SK, Tekell JL, Silva JA, Mahurin RK, McGinnis S, et al. Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biological Psychiatry. 2000;48:830–843
  25. Mischoulon D, Dougherty DD, Bottonari KA, Gresham RL, Sonawalla SB, Fischman AJ, et al. An open pilot study of nefazodone in depression with anger attacks: relationship between clinical response and receptor binding. Psychiatry Research: Neuroimaging. 2002;116:151–161
  26. Montkowski A, Barden N, Wotjak C, Stec I, Ganster J, Meaney M, et al. Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function. Journal of Neuroendocrinology. 1995;7:841–845
  27. Oshima A, Miyano H, Yamashita S, Owashi T, Suzuki S, Sakano Y, et al. Psychological, autonomic and neuroendocrine responses to acute stressors in the combined dexamethasone/CRH test: a study in healthy subjects. Journal of Psychiatric Research. 2001;35:95–104
  28. Perico CA, Skaf CR, Yamada A, Duran F, Buchpiguel CA, Castro CC, et al. Relationship between regional cerebral blood flow and separate symptom clusters of major depression: a single photon emission computed tomography study using statistical parametric mapping. Neuroscience Letters. 2005;384:265–270
  29. Reul JM, Stec I, Soder M, Holsboer F. Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system. Endocrinology. 1993;133:312–320
  30. Reul JM, Labeur MS, Grigoriadis DE, De Souza EB, Holsboer F. Hypothalamic-pituitary-adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide. Neuroendocrinology. 1994;60:509–519
  31. Sapolsky RM, Krey LC, McEwen BS. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocrine Reviews. 1986;7:284–301
  32. Schuckit MA. Trait (and state) markers of a predisposition to psychopathology. In:  Michels R,  Cavenar JO,  Cooper AM,  Guze SM,  Judd LL,  Klerman GL,  Solnit AJ editor. Psychiatry. vol. 53:Philadelphia, PA: JB Lippincott Co; 1988;p. 1–19
  33. Seckl JR, Fink G. Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo. Neuroendocrinology. 1992;55:621–626
  34. Sesack SR, Deutch AY, Roth RH, Bunney BS. Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. Journal of Comparative Neurology. 1989;290:213–242
  35. Smith GS, Reynolds CF, Pollock B, Derbyshire S, Nofzinger E, Dew MA, et al. Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression. American Journal of Psychiatry. 1999;156:683–689
  36. Stokes PE, Stoll PM, Koslow SH, Maas JW, Davis JM, Swann AC, et al. Pretreatment DST and hypothalamic-pituitary-adrenocortical function in depressed patients and comparison groups. A multicenter study. Archives of General Psychiatry. 1984;41:257–267
  37. Strome EM, Clark CM, Zis AP, Doudet DJ. Electroconvulsive shock decreases binding to 5-HT2 receptors in nonhuman primates: an in vivo positron emission tomography study with [18F]setoperone. Biological Psychiatry. 2005;57:1004–1010
  38. Surguladze S, Brammer MJ, Keedwell P, Giampietro V, Young AW, Travis MJ, et al. A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biological Psychiatry. 2005;57:201–209
  39. Tachiteya BM, Lecours AR, Elie R, Lupien SJ. Impact of a unilateral brain lesion on cortisol secretion and emotional state: anterior/posterior dissociation in humans. Psychoneuroendocrinology. 2003;28:674–686
  40. Videbech P, Ravnkilde B, Pedersen AR, Egander A, Landbo B, Rasmussen NA, et al. The Danish PET/depression project: PET findings in patients with major depression. Psychological Medicine. 2001;31:1147–1158
  41. World Health Organization Collaborative Study . The dexamethasone suppression test in depression. The British Journal of Psychiatry. 1987;150:459–462
  42. Worsley KJ, Evans AC, Marrett S, Neelin P. A three-dimensional statistical analysis for CBF activation studies in human brain. Journal of Cerebral Blood Flow and Metabolism. 1992;12:900–918
  43. Yatham LN, Liddle PF, Dennie J, Shiah IS, Adam MJ, Lane CJ, et al. Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperone. Archives of General Psychiatry. 1999;56:705–711

PII: S0925-4927(06)00206-X

doi: 10.1016/j.pscychresns.2006.11.002

Psychiatry Research: Neuroimaging
Volume 155, Issue 3 , Pages 245-256 , 15 August 2007

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