Association between serotonin transporter availability and hostility scores in healthy volunteers—A single photon emission computed tomography study with [123I] ADAM

Yang, Yen Kuang; Yao, Wei Jen; Yeh, Tzung Lieh; Lee, I Hui; Chen, Kao Ching; Lu, Ru Band

doi:10.1016/j.pscychresns.2006.11.010

« Previous Next »Psychiatry Research: Neuroimaging
Volume 154, Issue 3 , Pages 281-284, 15 April 2007

Association between serotonin transporter availability and hostility scores in healthy volunteers—A single photon emission computed tomography study with [¹²³I] ADAM

Yen Kuang Yang
- Department of Psychiatry, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 70403, Taiwan
- Department of Psychiatry, National Cheng Kung University, Hospital, Tainan, Taiwan
- Corresponding author. Tel.: +886 6 2353535x5213; fax: +886 6 2759259.
Wei Jen Yao
- Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Tzung Lieh Yeh
- Department of Psychiatry, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 70403, Taiwan
- Department of Psychiatry, National Cheng Kung University, Hospital, Tainan, Taiwan
I Hui Lee
- Department of Psychiatry, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 70403, Taiwan
- Department of Psychiatry, National Cheng Kung University, Hospital, Tainan, Taiwan
Kao Ching Chen
- Department of Psychiatry, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 70403, Taiwan
- Department of Psychiatry, National Cheng Kung University, Hospital, Tainan, Taiwan
Ru Band Lu
- Department of Psychiatry, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 70403, Taiwan
- Department of Psychiatry, National Cheng Kung University, Hospital, Tainan, Taiwan
- Institute of Behavior Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Received 3 March 2006; received in revised form 11 August 2006; accepted 26 November 2006.

Abstract

The present study examined the relationship between serotonin transporter (SERT) availability and hostility scores in healthy volunteers. SERT availability was measured by using SPECT with [¹²³I] ADAM in 10 healthy participants. Hostility was measured with the Cook–Medley Hostility Scale. Hostile attribution, but not the other subscales of hostility, was negatively correlated with SERT availability. Central serotoninergic activities may play a role in hostility.

Keywords: SPECT, Hostility scores, Serotonin transporter