Psychiatry Research: Neuroimaging
Volume 154, Issue 3 , Pages 267-273 , 15 April 2007

In vivo metabolite differences between the basal ganglia and cerebellum of the rat brain detected with proton MRS at 3T

  • Dirk Mayer

      Affiliations

    • Radiology Department Lucas MRS/I Center Stanford University, 1201 Welch Road, P-273, Stanford, California, 94305-5488, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 650 725 8009; fax: +1 650 723 5795.
  • ,
  • Natalie M. Zahr

      Affiliations

    • Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA United States
  • ,
  • Edith V. Sullivan

      Affiliations

    • Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA United States
  • ,
  • Adolf Pfefferbaum

      Affiliations

    • Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA United States
    • Neuroscience Program, SRI International Menlo Park, CA United States

Received 22 June 2006 ,Revised 18 September 2006 ,Accepted 26 November 2006.

References 

  1. Adalsteinsson E, Hurd RE, Mayer D, Sailasuta N, Sullivan EV, Pfefferbaum A. In vivo 2D J-resolved magnetic resonance spectroscopy of rat brain with a 3T clinical human scanner. NeuroImage. 2004;22:381–386
  2. Adalsteinsson, E., Sullivan, E.V., Mayer, D., Pfefferbaum, A. 2006. In vivo quantification of ethanol kinetics in rat brain. Neuropsychopharmacology, Epub ahead of print Janurary 11.
  3. Adalsteinsson E, Sullivan EV, Pfefferbaum A. Biochemical, functional and microstructural magnetic resonance imaging (MRI). In:  Liu Y,  Lovinger DM editor. Methods in Alcohol-Related Neuroscience Research. FL: CRC Press Boca Raton; 2002;p. 345–372
  4. Bendszus M, Weijers HG, Wiesbeck G, Warmuth-Metz M, Bartsch AJ, Engels S, et al. Sequential MR imaging and proton MR spectroscopy in patients who underwent recent detoxification for chronic alcoholism: correlation with clinical and neuropsychological data. American Journal of Neuroradiology. 2001;22:1926–1932
  5. Bottomley PA, Hardy CJ. Rapid, reliable in vivo assays of human phosphate metabolites by nuclear magnetic resonance. Clinical Chemistry. 1989;35:392–395
  6. De Stefano N, Matthews PM, Fu L, Narayanan S, Stanley J, Francis GS, et al. Axonal damage correlates with disability in patients with relapsing–remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study. Brain. 1998;121:1469–1477
  7. Dreher W, Leibfritz D. Detection of homonuclear decoupled in vivo proton NMR spectra using constant time chemical shift encoding: CT-PRESS. Magnetic Resonance Imaging. 1999;17:141–145
  8. Fein G, Meyerhoff D, Di Sclafani V, Ezekiel F, Poole N, MacKay S, et al. 1H magnetic resonance spectroscopic imaging separates neuronal from glial changes in alcohol-related brain atrophy. In:  Lancaster F editors. Alcohol and Glial Cells. NIAAA Research Monograph. vol. 27:MD: US Government Printing Office Bethesda; 1994;p. 227–241
  9. Filippi M, Rovaris M, Pereira C, Comi G. A longitudinal study comparing the sensitivity of CSE and RARE sequences in detecting new multiple sclerosis lesions. Magnetic Resonance Imaging. 1999;17:457–458
  10. Grachev ID, Apkarian AV. Chemical heterogeneity of the living human brain: a proton MR spectroscopy study on the effects of sex, age, and brain region. NeuroImage. 2000;11:554–563
  11. Hoffman PL, Rabe CS, Grant KA, Valverius P, Hudspith M, Tabakoff B. Ethanol and the NMDA receptor. Alcohol. 1990;7:229–231
  12. Hurd R, Sailasuta N, Srinivasan R, Vigneron DB, Pelletier D, Nelson SJ. Measurement of brain glutamate using TE-averaged PRESS at 3T. Magnetic Resonance Medicine. 2004;51:435–440
  13. Jagannathan NR, Desai NG, Raghunathan P. Brain metabolite changes in alcoholism: an in vivo proton magnetic resonance spectroscopy (MRS) study. Magnetic Resonance Imaging. 1996;14:553–557
  14. Jansen JF, Backes WH, Nicolay K, Kooi ME. 1H MR spectroscopy of the brain: absolute quantification of metabolites. Radiology. 2006;240:318–332
  15. Kalivas PW, Volkow N, Seamans J. Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission. Neuron. 2005;45:647–650
  16. Koob GF. The role of the striatopallidal and extended amygdala systems in drug addiction. Annals of the New York Academy of Science. 1999;877:445–460
  17. Lovinger DM. NMDA receptors lose their inhibitions. Nature Neuroscience. 2002;5:614–616
  18. Mann K, Seitz D, Widman U, Grodd W. Proton MR Spectroscopy of the Cerebellum in Detoxified Alcoholics and Healthy Controls (abs). American College of Neuropsychopharmacology; 1998;
  19. Martin PR, Gibbs SJ, Nimmerrichter AA, Riddle WR, Welch LW, Willcott MR. Brain proton magnetic resonance spectroscopy studies in recently abstinent alcoholics. Alcoholism. Clinical and Experimental Research. 1995;19:1078–1082
  20. Mayer D, Spielman DM. Detection of glutamate in the human brain at 3 T using optimized constant time point resolved spectroscopy. Magnetic Resonance Medicine. 2005;54:439–442
  21. Melendez RI, Hicks MP, Cagle SS, Kalivas PW. Ethanol exposure decreases glutamate uptake in the nucleus accumbens. Alcoholism Clinical and Experimental Research. 2005;29:326–333
  22. Miller BL. A review of chemical issues in 1H NMR spectroscopy: N-acetyl-l-aspartate, creatine and choline. NMR in Biomedicine. 1991;4:47–52
  23. Moghaddam B, Bolinao ML. Biphasic effect of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbens. Neuroscience Letters. 1994;178:99–102
  24. Moore GJ, Galloway MP. Magnetic resonance spectroscopy: neurochemistry and treatment effects in affective disorders. Psychopharmacology Bulletin. 2002;36:5–23
  25. Morrisett RA, Martin D, Oetting TA, Lewis DV, Wilson WA, Swartzwelder HS. Ethanol and magnesium ions inhibit N-methyl-d-aspartate-mediated synaptic potentials in an interactive manner. Neuropharmacology. 1991;30:1173–1178
  26. Novak JE, Turner RS, Agranoff BW, Fisher SK. Differentiated human NT2-N neurons possess a high intracellular content of myo-inositol. Journal of Neurochemistry. 1999;72:1431–1440
  27. O'Neill J, Cardenas VA, Meyerhoff DJ. Effects of abstinence on the brain: quantitative magnetic resonance imaging and magnetic resonance spectroscopic imaging in chronic alcohol abuse. Alcoholism, Clinical and Experimental Research. 2001;25:1673–1682
  28. Parks MH, Dawant BM, Riddle WR, Hartmann SL, Dietrich MS, Nickel MK, et al. Longitudinal brain metabolic characterization of chronic alcoholics with proton magnetic resonance spectroscopy. Alcoholism, Clinical and Experimental Research. 2002;26:1368–1380
  29. Paxinos G, Watson C. The rat brain in stereotaxic coordinates — the new coronal set. Fifth Edition. Sydney: Elsevier; 2004;
  30. Peeling J, Shoemaker L, Gauthier T, Benarroch A, Sutherland GR, Minuk GY. Cerebral metabolic and histological effects of thioacetamide-induced liver failure. American Journal of Physiology. 1993;265:G572–G578
  31. Pfefferbaum A, Adalsteinsson E, Spielman D, Sullivan EV, Lim KO. In vivo brain concentrations of N-acetyl compounds, creatine and choline in Alzheimer's disease. Archives of General Psychiatry. 1999;56:185–192
  32. Pfefferbaum A, Adalsteinsson E, Spielman D, Sullivan EV, Lim KO. In vivo spectroscopic quantification of the N-acetyl moiety, creatine and choline from large volumes of gray and white matter: effects of normal aging. Magnetic Resonance in Medicine. 1999;41:276–284
  33. Pfefferbaum A, Adalsteinsson E, Sullivan EV. In vivo structural imaging of the rat brain with a 3T clinical human scanner. Journal of Magnetic Resonance Imaging. 2004;20:779–785
  34. Pfefferbaum, A., Adalsteinsson, E., Bell, R.L., Sullivan, E.V., 2006. Development and resolution of brain lesions caused by pyrithiamine and dietary Induced thiamine deficiency and alcohol exposure in the alcohol-preferring (P) Rat: A longitudinal MR imaging and spectroscopy study. Neuropsychopharmacology, Epub, May 24, 2006
  35. Plock N, Kloft C. Microdialysis-theoretical background and recent implementation in applied life-sciences. European Journal of Pharmaceutical Sciences. 2005;25:1–24
  36. Snell LD, Tabakoff B, Hoffman PL. Radioligand binding to the N-methyl-d-aspartate receptor/ionophore complex: alterations by ethanol in vitro and by chronic in vivo ethanol ingestion. Brain Research. 1993;602:91–98
  37. Sullivan EV. Compromised pontocerebellar and cerebellothalamocortical systems: speculations on their contributions to cognitive and motor impairment in nonamnesic alcoholism. Alcoholism, Clinical and Experimental Research. 2003;27:1409–1419
  38. Sullivan EV, Pfefferbaum A. Neurocircuitry in alcoholism: a substrate of disruption and repair. Psychopharmacology. 2005;180:583–594
  39. Sullivan EV, Harding AJ, Pentney R, Dlugos C, Martin PR, Parks MH, et al Disruption of frontocerebellar circuitry and function in alcoholism. Alcoholism, Clinical and Experimental Research. 2003;27:301–309
  40. Tedeschi G, Bertolino A, Righini A, Campbell G, Raman R, Duyn JH, et al. Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging. Neurology. 1995;45:1384–1391
  41. Tkac I, Henry PG, Andersen P, Keene CD, Low WC, Gruetter R. Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 T. Magnetic Resonance in Medicine. 2004;52:478–484
  42. Tkac I, Rao R, Georgieff MK, Gruetter R. Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy. Magnetic Resonance in Medicine. 2003;50:24–32
  43. Weiss F, Koob GF. Drug addiction: functional neurotoxicity of the brain reward systems. Neurotoxicity Research. 2001;3:145–156

PII: S0925-4927(06)00203-4

doi: 10.1016/j.pscychresns.2006.11.005

Psychiatry Research: Neuroimaging
Volume 154, Issue 3 , Pages 267-273 , 15 April 2007