Psychiatry Research: Neuroimaging
Volume 154, Issue 3 , Pages 275-279 , 15 April 2007

Increased striatal gray matter densities in patients with schizophrenia and substance use disorder: A voxel-based morphometry study

  • Stéphane Potvin

      Affiliations

    • Department of Psychiatry, Fernand-Seguin Research Center, University of Montreal, Canada
    • Department of Psychiatry, Louis-H Lafontaine Hospital, University of Montreal, Canada
    • Biomedical Sciences Program, Faculty of Medicine, University of Montreal, Canada
  • ,
  • Adham Mancini-Marïe

      Affiliations

    • Department of Psychiatry, Fernand-Seguin Research Center, University of Montreal, Canada
    • Department of Psychiatry, Louis-H Lafontaine Hospital, University of Montreal, Canada
    • Biomedical Sciences Program, Faculty of Medicine, University of Montreal, Canada
  • ,
  • Chérine Fahim

      Affiliations

    • Department of Psychiatry, Fernand-Seguin Research Center, University of Montreal, Canada
    • Department of Psychiatry, Louis-H Lafontaine Hospital, University of Montreal, Canada
    • Department of Neurological Sciences, Faculty of Medicine, University of Montreal, Canada
  • ,
  • Boualem Mensour

      Affiliations

    • Department of Radiology, Centre hospitalier de l'Université de Montréal (CHUM), University of Montreal, Canada
  • ,
  • Johanne Lévesque

      Affiliations

    • Department of Psychology, Neuropsychology and Cognition Research Centre, University of Montreal, Canada
  • ,
  • Sherif Karama

      Affiliations

    • Department of Psychiatry, Clinical Research Division, Douglas Hospital Research Center, Mcgill University, Canada
  • ,
  • Mario Beauregard

      Affiliations

    • Department of Radiology, Centre hospitalier de l'Université de Montréal (CHUM), University of Montreal, Canada
    • Department of Neurological Sciences, University of Montreal, Canada
  • ,
  • Pierre-Paul Rompré

      Affiliations

    • Department of Psychiatry, Fernand-Seguin Research Center, University of Montreal, Canada
    • Department of Psychiatry, Louis-H Lafontaine Hospital, University of Montreal, Canada
    • Department of Psychiatry, Faculty of Medicine, University of Montreal, Canada
  • ,
  • Emmanuel Stip

      Affiliations

    • Department of Psychiatry, Fernand-Seguin Research Center, University of Montreal, Canada
    • Department of Psychiatry, Louis-H Lafontaine Hospital, University of Montreal, Canada
    • Department of Psychiatry, Faculty of Medicine, University of Montreal, Canada
    • Corresponding Author InformationCorresponding author. Centre de recherche Fernand-Seguin; 7331 Hochelaga; Montreal, Quebec, Canada H1N 3V2. Tel.: +1 514 251 4015; fax: +1 514 251 2617.

Received 2 June 2006 ,Revised 3 November 2006 ,Accepted 27 November 2006.

References 

  1. Ashburner J, Friston KJ. Voxel-based morphometry—the methods. NeuroImage. 2000;11:805–821
  2. Bertolino A, Caforio G, Petruzzella V, Latorre V, Rubino V, Dimalta S, et al. Prefrontal dysfunction in schizophrenia controlling for COMT Val(158)Met genotype and working memory performance. Psychiatry Research. 2006;147:221–226
  3. Boileau I, Assad JM, Pihl RO, Benkelfat C, Leyton M, Diksic M, et al. Alcohol promotes dopamine release in the human nucleus accumbens. Synapse. 2003;49:226–231
  4. Caspi A, Moffitt TE, Cannon M, McClay J, Murray R, Harrington H, et al. Moderation of the effects of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene × environment interaction. Biological Psychiatry. 2005;57:1110–1127
  5. Chambers RA, Taylor JR. Animal modelling dual diagnosis schizophrenia: sensitization to cocaine in rats with neonatal ventral hippocampal lesions. Biological Psychiatry. 2004;56:308–316
  6. Drake RE, Osher FC, Noordsy DL, Hurlbut SC, Teague GB, Beaudett MS. Diagnosis of alcohol use disorders in schizophrenia. Schizophrenia Bulletin. 1990;16:57–67
  7. Friston KJ, Ashburner J, Poline JB, Frith CD, Heather JD, Frackowiak RSJ. Spatial registration and normalization of images. Human Brain Mapping. 1995;2:165–189
  8. Gardner EL, Vorel SR. Cannabinoid transmission and reward-related events. Neurobiology of Disease. 1998;5:502–533
  9. Giuliani NR, Calhoun VD, Pearlson GD, Francis A, Buchanan RW. Voxel-based morphometry versus region of interest: a comparison of two methods for analyzing gray matter differences in schizophrenia. Schizophrenia Research. 2005;74:135–147
  10. Goldstein RZ, Volkow ND. Drug addiction and its underlying neurobiological basis: neuroimaging evidence of the involvement of the frontal cortex. American Journal of Psychiatry. 2002;159:1642–1652
  11. Ha TH, Youn T, Ha KS, Rho KS, Lee JM, Kim IY, et al. Gray matter abnormalities in paranoid schizophrenia and their clinical correlates. Psychiatry Research Neuroimaging. 2004;132:251–260
  12. Hulshoff Pol HE, Schnack HG, Mandl RC, van Haren NE, Koning H, Collins DL, et al. Focal gray matter density changes in schizophrenia. Archives of General Psychiatry. 2001;58:1118–1125
  13. Hyman SE, Malenka RC. Addiction and the brain: the neurobiology of compulsion and its persistence. Nature Reviews Neuroscience. 2001;2:695–703
  14. Joyal CC, Pennanen C, Tiihonen E, Laakso M, Tiihonen J, Aronen HJ. MRI volumetry of the vermis and the cerebellar hemispheres in men with schizophrenia. Psychiatry Research Neuroimaging. 2004;131:115–124
  15. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  16. Kubicki M, Shenton ME, Salisbury DF, Hirayasu Y, Kasai K, Kikinis R, et al. Voxel-based morphometric analysis of gray matter in first episode schizophrenia. NeuroImage. 2002;17:1711–1719
  17. Laruelle M, Abi-Dargham A. Dopamine as the wind of psychotic fire: new evidence from brain imaging studies. Journal of Psychopharmacology. 1999;13:358–371
  18. Massana G, Salgado-Pineda P, Junque C, Perez M, Baeza I, Pons A, et al. Volume changes in gray matter in first-episode neuroleptic-naïve schizophrenic patients treated with risperidone. Journal of Clinical Psychopharmacology. 2005;25:111–117
  19. Mueser KT, Drake RE, Wallach MA. Dual diagnosis: a review of etiological theories. Addictive Behaviors. 1998;23:717–734
  20. Neckelmann G, Specht K, Lund A, Ersland L, Smievoll AI, Neckelmann D, et al. Mr morphometry analysis of grey matter volume reduction in schizophrenia: association with hallucinations. International Journal of Neuroscience. 2006;116:9–23
  21. Rodriguez de Fonseca F, Del Arco I, Martin-Calderon JL, Gorriti MA, Navarro M. Role of the endogenous cannabinoid system in the regulation of motor activity. Neurobiology of Disease. 1998;6:483–501
  22. Rutter M, Moffitt TE, Caspi A. Gene–environment interplay and psychopathology: multiple varieties but real effects. Journal of Child Psychology and Psychiatry. 2006;47:226–261
  23. Salgado-Pineda P, Junque C, Vendrell P, Baeza I, Bargallo N, Falcon C, et al. Decreased cerebral activation during CPT performance: structural and functional deficits in schizophrenic patients. NeuroImage. 2004;21:840–847
  24. Seeman P. Atypical antipsychotics: mechanism of action. Canadian Journal of Psychiatry. 2002;47:27–38
  25. Sullivan EV, Pfefferbaum A. Neurocircuitry in alcoholism: a substrate of disruption and repair. Psychopharmacology. 2005;180:583–594
  26. Sullivan EV, Deshmukh A, Desmond JE, Mathalon DH, Rosenbloom MJ, Lim KO, et al. Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia. Archives of General Psychiatry. 2000;57:894–902
  27. Sullivan EV, Rosenbloom MJ, Serventi KL, Desmukh A, Pfefferbaum A. Effects of alcohol dependence comorbidity and antipsychotic medication on volumes of the thalamus and pons in schizophrenia. American Journal of Psychiatry. 2003;160:1110–1116
  28. Wise RA. Brain reward circuitry: insights from unsensed incentives. Neuron. 2002;36:229–240
  29. Woods SW. Chlorpromazine equivalent doses for the newer atypical antipsychotics. Journal of Clinical Psychiatry. 2003;64:663–667
  30. Wright IC, McGuire PK, Poline JB, Travere JM, Murray RM, Frith CD, et al. A voxel-based method for the statistical analysis of gray and white matter density applied to schizophrenia. NeuroImage. 1995;2:244–252

PII: S0925-4927(06)00202-2

doi: 10.1016/j.pscychresns.2006.11.009

Psychiatry Research: Neuroimaging
Volume 154, Issue 3 , Pages 275-279 , 15 April 2007