Increased striatal gray matter densities in patients with schizophrenia and substance use disorder: A voxel-based morphometry study

Potvin, Stéphane; Mancini-Marïe, Adham; Fahim, Chérine; Mensour, Boualem; Lévesque, Johanne; Karama, Sherif; Beauregard, Mario; Rompré, Pierre-Paul; Stip, Emmanuel

doi:10.1016/j.pscychresns.2006.11.009

« Previous Next »Psychiatry Research: Neuroimaging
Volume 154, Issue 3 , Pages 275-279, 15 April 2007

Increased striatal gray matter densities in patients with schizophrenia and substance use disorder: A voxel-based morphometry study

Stéphane Potvin
- Department of Psychiatry, Fernand-Seguin Research Center, University of Montreal, Canada
- Department of Psychiatry, Louis-H Lafontaine Hospital, University of Montreal, Canada
- Biomedical Sciences Program, Faculty of Medicine, University of Montreal, Canada
Adham Mancini-Marïe
- Department of Psychiatry, Fernand-Seguin Research Center, University of Montreal, Canada
- Department of Psychiatry, Louis-H Lafontaine Hospital, University of Montreal, Canada
- Biomedical Sciences Program, Faculty of Medicine, University of Montreal, Canada
Chérine Fahim
- Department of Psychiatry, Fernand-Seguin Research Center, University of Montreal, Canada
- Department of Psychiatry, Louis-H Lafontaine Hospital, University of Montreal, Canada
- Department of Neurological Sciences, Faculty of Medicine, University of Montreal, Canada
Boualem Mensour
- Department of Radiology, Centre hospitalier de l'Université de Montréal (CHUM), University of Montreal, Canada
Johanne Lévesque
- Department of Psychology, Neuropsychology and Cognition Research Centre, University of Montreal, Canada
Sherif Karama
- Department of Psychiatry, Clinical Research Division, Douglas Hospital Research Center, Mcgill University, Canada
Mario Beauregard
- Department of Radiology, Centre hospitalier de l'Université de Montréal (CHUM), University of Montreal, Canada
- Department of Neurological Sciences, University of Montreal, Canada
Pierre-Paul Rompré
- Department of Psychiatry, Fernand-Seguin Research Center, University of Montreal, Canada
- Department of Psychiatry, Louis-H Lafontaine Hospital, University of Montreal, Canada
- Department of Psychiatry, Faculty of Medicine, University of Montreal, Canada
Emmanuel Stip
- Department of Psychiatry, Fernand-Seguin Research Center, University of Montreal, Canada
- Department of Psychiatry, Louis-H Lafontaine Hospital, University of Montreal, Canada
- Department of Psychiatry, Faculty of Medicine, University of Montreal, Canada
- Corresponding author. Centre de recherche Fernand-Seguin; 7331 Hochelaga; Montreal, Quebec, Canada H1N 3V2. Tel.: +1 514 251 4015; fax: +1 514 251 2617.

Received 2 June 2006; received in revised form 3 November 2006; accepted 27 November 2006.

Abstract

We sought to investigate the link between substance abuse and increased striatal gray matter densities (GMD) in schizophrenia, using voxel-based morphometry (VBM). Increased striatal GMD were found in patients with schizophrenia and substance use disorder (n=12), but not schizophrenia only patients (n=11), compared to healthy volunteers (n=15).