Psychiatry Research: Neuroimaging
Volume 154, Issue 3 , Pages 199-208 , 15 April 2007

Basal ganglia volumes in drug-naive first-episode schizophrenia patients before and after short-term treatment with either a typical or an atypical antipsychotic drug

  • Andreas Glenthoj

      Affiliations

    • Danish Research Centre for Magnetic Resonance Imaging, University of Copenhagen, Hvidovre Hospital, Denmark
  • ,
  • Birte Y. Glenthoj

      Affiliations

    • Center for Neuropsychiatric Schizophrenia Research, University of Copenhagen, Psychiatric Centre Glostrup, DK-2600, Denmark
    • Corresponding Author InformationCorresponding author. Tel.: +45 43 23 46 39; fax: +45 43 23 46 53.
  • ,
  • Torben Mackeprang

      Affiliations

    • Center for Neuropsychiatric Schizophrenia Research, University of Copenhagen, Department of Psychiatry E, Bispebjerg Hospital, Copenhagen, Denmark
    • Deceased.
  • ,
  • Anne K. Pagsberg

      Affiliations

    • Department of Child and Adolescent Psychiatry F, Bispebjerg Hospital, Copenhagen, Denmark
  • ,
  • Ralf P. Hemmingsen

      Affiliations

    • Center for Neuropsychiatric Schizophrenia Research, University of Copenhagen, Department of Psychiatry E, Bispebjerg Hospital, Copenhagen, Denmark
  • ,
  • Terry L. Jernigan

      Affiliations

    • Danish Research Centre for Magnetic Resonance Imaging, University of Copenhagen, Hvidovre Hospital, Denmark
  • ,
  • William F.C. Baaré

      Affiliations

    • Danish Research Centre for Magnetic Resonance Imaging, University of Copenhagen, Hvidovre Hospital, Denmark

Received 26 April 2006 ,Revised 19 September 2006 ,Accepted 20 October 2006.

References 

  1. Andersson C, Hamer RM, Lawler CP, Mailman RB, Lieberman JA. Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs. Neuropsychopharmacology. 2002;27:143–151
  2. Bracha HS. Etiology of structural asymmetry in schizophrenia: an alternative hypothesis. Schizophrenia Bulletin. 1991;17:551–553
  3. Breier A, Buchanan RW, Elkashef A, Munson RC, Kirkpatrick B, Gellad F. Brain morphology and schizophrenia. A magnetic resonance imaging study of limbic, prefrontal cortex, and caudate structures. Archives of General Psychiatry. 1992;49:921–926
  4. Cahn W, Pol HE, Bongers M, Schnack HG, Mandl RC, Van Haren NE, et al. Brain morphology in antipsychotic-naive schizophrenia: a study of multiple brain structures. British Journal of Psychiatry (Supplement). 2002;43:s66–s72
  5. Chakos MH, Lieberman JA, Bilder RM, Borenstein M, Lerner G, Bogerts B, et al. Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs. American Journal of Psychiatry. 1994;151:1430–1436
  6. Chakos MH, Lieberman JA, Alvir J, Bilder R, Ashtari M. Caudate nuclei volumes in schizophrenic patients treated with typical antipsychotics or clozapine. Lancet. 1995;345(8947):456–457
  7. Choi JS, Kang DH, Kim JJ, Ha TH, Roh KS, Youn T, et al. Decreased caudal anterior cingulate gyrus volume and positive symptoms in schizophrenia. Psychiatry Research: Neuroimaging. 2005;139:239–247
  8. Chouinard G, Ross-Chouinard A. Extrapyramidal Symptom Rating Scale (ESRS). Canada: Montreal; 1979;
  9. Chow EW, Bassett AS, Weksberg R. Velo-cardio-facial syndrome and psychotic disorders: implications for psychiatric genetics. American Journal of Medical Genetics. 1994;54:107–112
  10. Chua SE, McKenna PJ. Schizophrenia—a brain disease? A critical review of structural and functional cerebral abnormality in the disorder. British Journal of Psychiatry. 1995;166:563–582
  11. Corson PW, Nopoulos P, Andreasen NC, Heckel D, Arndt S. Caudate size in first-episode neuroleptic-naive schizophrenic patients measured using an artificial neural network. Biological Psychiatry. 1999;46:712–720
  12. Corson PW, Nopoulos P, Miller DD, Arndt S, Andreasen NC. Change in basal ganglia volume over 2 years in patients with schizophrenia: typical versus atypical neuroleptics. American Journal of Psychiatry. 1999;156:1200–1204
  13. Crow TJ. Schizophrenia as failure of hemispheric dominance for language. Trends in Neurosciences. 1997;20:339–343
  14. DeLisi LE, Hoff AL, Schwartz JE, Shields GW, Halthore SN, Gupta SM, et al. Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study. Biological Psychiatry. 1991;29:159–175
  15. Elkashef AM, Buchanan RW, Gellad F, Munson RC, Breier A. Basal ganglia pathology in schizophrenia and tardive dyskinesia: an MRI quantitative study. American Journal of Psychiatry. 1994;151:752–755
  16. Ettinger U, Kumari V, Chitnis XA, Corr PJ, Crawford TJ, Fannon DG, et al. Volumetric neural correlates of antisaccade eye movements in first-episode psychosis. American Journal of Psychiatry. 2004;161:1918–1921
  17. Fink-Jensen A. Novel pharmacological approaches to the treatment of schizophrenia. Danish Medical Bulletin. 2000;47:151–167
  18. Frazier JA, Giedd JN, Kaysen D, Albus K, Hamburger S, aghband-Rad J, et al. Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment. American Journal of Psychiatry. 1996;153:564–566
  19. Gunduz H, Wu H, Ashtari M, Bogerts B, Crandall D, Robinson DG, et al. Basal ganglia volumes in first-episode schizophrenia and healthy comparison subjects. Biological Psychiatry. 2002;51:801–808
  20. Gur RE, Cowell P, Turetsky BI, Gallacher F, Cannon T, Bilker W, et al. A follow-up magnetic resonance imaging study of schizophrenia. Relationship of neuroanatomical changes to clinical and neurobehavioral measures. Archives of General Psychiatry. 1998;55:145–152
  21. Gur RE, Maany V, Mozley PD, Swanson C, Bilker W, Gur RC. Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia. Archives of General Psychiatry. 1998;155:1711–1717
  22. Hansen EJ. Danskernes levekår, Copenhagen. 1986;
  23. Harrison PJ. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain. 1999;122(4):593–624
  24. Heitmiller DR, Nopoulos PC, Andreasen NC. Changes in caudate volume after exposure to atypical neuroleptics in patients with schizophrenia may be sex-dependent. Schizophrenia Research. 2004;66:137–142
  25. Hokama H, Shenton ME, Nestor PG, Kikinis R, Levitt JJ, Metcalf D, et al. Caudate, putamen, and globus pallidus volume in schizophrenia: a quantitative MRI study. Psychiatry Research: Neuroimaging. 1995;61:209–229
  26. Hulshoff Pol HE, Schnack HG, Mandl RC, Van Haren NE, Koning H, Collins DL, et al. Focal gray matter density changes in schizophrenia. Archives of General Psychiatry. 2001;58:1118–1125
  27. Hynd GW, Hern KL, Novey ES, Eliopulos D, Marshall R, Gonzalez JJ, et al. Attention deficit-hyperactivity disorder and asymmetry of the caudate nucleus. Journal of Child Neurology. 1993;8:339–347
  28. Ifthikharuddin SF, Shrier DA, Numaguchi Y, Tang X, Ning R, Shibata DK, et al. MR volumetric analysis of the human basal ganglia: normative data. Academic Radiology. 2000;7:627–634
  29. Jernigan TL, Zisook S, Heaton RK, Moranville JT, Hesselink JR, Braff DL. Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia. Archives of General Psychiatry. 1991;48:881–890
  30. Kapur S, Remington G. Dopamine D2 receptors and their role in atypical antipsychotic action: still necessary and may even be sufficient. Biological Psychiatry. 2001;50:873–883
  31. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  32. Keshavan MS, Bagwell WW, Haas GL, Sweeney JA, Schooler NR, Pettegrew JW. Changes in caudate volume with neuroleptic treatment. Lancet. 1994;344(8934):1434
  33. Keshavan MS, Rosenberg D, Sweeney JA, Pettegrew JW. Decreased caudate volume in neuroleptic-naive psychotic patients. American Journal of Psychiatry. 1998;155:774–778
  34. Lang DJ, Kopala LC, Vandorpe RA, Rui Q, Smith GN, Goghari VM, et al. An MRI study of basal ganglia volumes in first-episode schizophrenia patients treated with risperidone. American Journal of Psychiatry. 2001;158:625–631
  35. Lieberman J, Chakos M, Wu H, Alvir J, Hoffman E, Robinson D, et al. Longitudinal study of brain morphology in first episode schizophrenia. Biological Psychiatry. 2001;49:487–499
  36. Massana G, Salgado-Pineda P, Junque C, Perez M, Baeza I, Pons A, et al. Volume changes in gray matter in first-episode neuroleptic-naive schizophrenic patients treated with risperidone. Journal of Clinical Psychopharmacology. 2005;25:111–117
  37. McCreadie RG, Thara R, Padmavati R, Srinivasan TN, Jaipurkar SD. Structural brain differences between never-treated patients with schizophrenia, with and without dyskinesia, and normal control subjects: a magnetic resonance imaging study. Archives of General Psychiatry. 2002;59:332–336
  38. Meador-Woodruff JH, Damask SP, Wang J, Haroutunian V, Davis KL, Watson SJ. Dopamine receptor mRNA expression in human striatum and neocortex. Neuropsychopharmacology. 1996;15:17–29
  39. Middleton FA, Strick PL. Basal ganglia output and cognition: evidence from anatomical, behavioral, and clinical studies. Brain and Cognition. 2000;42:183–200
  40. Nyberg S, Eriksson B, Oxenstierna G, Halldin C, Farde L. Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients. American Journal of Psychiatry. 1999;156:869–875
  41. Parent A. Extrinsic connections of the basal ganglia. Trends in Neurosciences. 1990;13:254–258
  42. Peterson BS, Thomas P, Kane MJ, Scahill L, Zhang H, Bronen R, et al. Basal ganglia volumes in patients with Gilles de la Tourette syndrome. Archives of General Psychiatry. 2003;60:415–424
  43. Pruessner JC, Li LM, Serles W, Pruessner M, Collins DL, Kabani N, et al. Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories. Cerebral Cortex. 2000;10:433–442
  44. Raz N, Torres IJ, Acker JD. Age, gender, and hemispheric differences in human striatum: a quantitative review and new data from in vivo MRI morphometry. Neurobiology of Learning and Memory. 1995;63:133–142
  45. Scheepers FE, Gispen de Wied CC, Hulshoff Pol HE, Kahn RS. Effect of clozapine on caudate nucleus volume in relation to symptoms of schizophrenia. American Journal of Psychiatry. 2001;158:644–646
  46. Shenton ME, Dickey CC, Frumin M, McCarley RW. A review of MRI findings in schizophrenia. Schizophrenia Research. 2001;49:1–52
  47. Shihabuddin L, Buchsbaum MS, Hazlett EA, Haznedar MM, Harvey PD, Newman A, et al. Dorsal striatal size, shape, and metabolic rate in never-medicated and previously medicated schizophrenics performing a verbal learning task. Archives of General Psychiatry. 1998;55:235–243
  48. Shihabuddin L, Buchsbaum MS, Hazlett EA, Silverman J, New A, Brickman AM, et al. Striatal size and relative glucose metabolic rate in schizotypal personality disorder and schizophrenia. Archives of General Psychiatry. 2001;58:877–884
  49. Skarsfeldt T. Differential effects of repeated administration of novel antipsychotic drugs on the activity of midbrain dopamine neurons in the rat. European Journal of Pharmacology. 1995;281:289–294
  50. Sled JG, Zijdenbos AP, Evans AC. A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Transactions on Medical Imaging. 1998;17:87–97
  51. Sommer I, Ramsey N, Kahn R, Aleman A, Bouma A. Handedness, language lateralisation and anatomical asymmetry in schizophrenia: meta-analysis. British Journal of Psychiatry. 2001;178:344–351
  52. Staal WG, Hulshoff Pol HE, Schnack HG, Hoogendoorn ML, Jellema K, Kahn RS. Structural brain abnormalities in patients with schizophrenia and their healthy siblings. American Journal of Psychiatry. 2000;157:416–421
  53. Sugama S, Bingham PM, Wang PP, Moss EM, Kobayashi H, Eto Y. Morphometry of the head of the caudate nucleus in patients with velocardiofacial syndrome (del 22q11.2). Acta Paediatrica. 2000;89:546–549
  54. Szabo CA, Lancaster JL, Xiong J, Cook C, Fox P. MR imaging volumetry of subcortical structures and cerebellar hemispheres in normal persons. AJNR. American Journal of Neuroradiology. 2003;24:644–647
  55. Talairach J, Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain. Three-Dimensional Proportional System: An Approach to Cerebral Imaging. New York: Thieme; 1988;
  56. Tauscher-Wisniewski S, Tauscher J, Logan J, Christensen BK, Mikulis DJ, Zipursky RB. Caudate volume changes in first episode psychosis parallel the effects of normal aging: a 5-year follow-up study. Schizophrenia Research. 2002;58:185–188
  57. Taylor S, Christensen JD, Holcomb JM, Garver DL. Volume increases in striatum associated with positive symptom reduction in schizophrenia: a preliminary observation. Psychiatry Research: Neuroimaging. 2005;140:85–89
  58. Watkins KE, Paus T, Lerch JP, Zijdenbos A, Collins DL, Neelin P, et al. Structural asymmetries in the human brain: a voxel-based statistical analysis of 142 MRI scans. Cerebral Cortex. 2001;11:868–877
  59. World Health Organization . The ICD-10 Classification of Mental and Behavioural Disorders. Diagnostic Criteria for Research WHO, Geneva. 1993;
  60. World Health Organization . Schedules for Clinical Assessment in Neuropsychiatry. 2.0 ed.. 1994;WHO, Geneva
  61. Wright IC, Rabe-Hesketh S, Woodruff PW, David AS, Murray RM, Bullmore ET. Meta-analysis of regional brain volumes in schizophrenia. American Journal of Psychiatry. 2000;157:16–25

 Presented in part at the International Congress on Schizophrenia Research, Savannah, Georgia, USA, March–April 2005, and at the World Federation of Societies of Biological Psychiatry 8th World Congress of Biological Psychiatry, June–July 2005.

PII: S0925-4927(06)00187-9

doi: 10.1016/j.pscychresns.2006.10.002

Psychiatry Research: Neuroimaging
Volume 154, Issue 3 , Pages 199-208 , 15 April 2007