Psychiatry Research: Neuroimaging
Volume 154, Issue 2 , Pages 191-198 , 28 February 2007

Smaller right hippocampus in war veterans with posttraumatic stress disorder

  • Ladislav Pavić

      Affiliations

    • Radiology Department, University Hospital Dubrava, Avenija Gojka Šuška 6, Zagreb, Croatia
    • Corresponding Author InformationCorresponding author. Tel./fax: +385 1 290 32 55.
  • ,
  • Rudolf Gregurek

      Affiliations

    • Clinic for Psychological Medicine, Medical School of the University of Zagreb, Kispaticeva 12, Zagreb, Croatia
  • ,
  • Marko Radoš

      Affiliations

    • Radiology Department, Medical School of the University of Zagreb, Kišpatićeva 12, Zagreb, Croatia
  • ,
  • Boris Brkljačić

      Affiliations

    • Radiology Department, University Hospital Dubrava, Avenija Gojka Šuška 6, Zagreb, Croatia
  • ,
  • Lovorka Brajković

      Affiliations

    • Clinic for Psychological Medicine, Medical School of the University of Zagreb, Kispaticeva 12, Zagreb, Croatia
  • ,
  • Ivana Šimetin-Pavić

      Affiliations

    • Croatian National Institute of Public Health, Rockefellerova 7, Zagreb, Croatia
  • ,
  • Gordana Ivanac

      Affiliations

    • Radiology Department, University Hospital Dubrava, Avenija Gojka Šuška 6, Zagreb, Croatia
  • ,
  • Goran Pavliša

      Affiliations

    • Radiology Department, Medical School of the University of Zagreb, Kišpatićeva 12, Zagreb, Croatia
  • ,
  • Vladimir Kalousek

      Affiliations

    • Radiology Department, University Hospital “Sisters of Mercy”, Vinogradska ul. 3, Zagreb, Croatia

Received 17 January 2006 ,Revised 14 June 2006 ,Accepted 27 August 2006.

References 

  1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. Ed 4. Washington, DC: APA; 1994;
  2. Bonne O, Brandes D, Gilboa A, Gomori JM, Shenton ME, Pitman RK, et al. Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD. American Journal of Psychiatry. 2001;158:1248–1251
  3. Bremner JD, Randall PR, Scott TM, Bronen RA, Delaney RC, Seibyl JP, et al. MRI-based measurement of hippocampal volume in posttraumatic stress disorder. American Journal of Psychiatry. 1995;152:973–981
  4. Bremner JD, Randall P, Vermetten E, Staib L, Bronen RA, Mazure C, et al. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry. 1997;41:23–32
  5. Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Nazeer A, et al. MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. American Journal of Psychiatry. 2003;160:924–932
  6. Carrion VG, Weems CF, Eliez S, Patwardhan A, Brown W, Ray RD, et al. Attention of frontal asymmetry in pediatric posttraumatic stress disorder. Biological Psychiatry. 2001;50:943–951
  7. De Bellis MD, Keshavan MS, Clark DB, Casey BJ, Giedd JN, Boring AM, et al. Developmental traumatology: Part II. Brain development. Biological Psychiatry. 1999;45:1271–1284
  8. De Bellis MD, Hall J, Boring AM, Frustaci K, Moritz G. A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder. Biological Psychiatry. 2001;50:305–309
  9. De Bellis MD, Keshavan MS, Shifflett H, Iyengar S, Beers SR, Hall J, et al. Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study. Biological Psychiatry. 2002;52:1066–1078
  10. Fennema-Notestine C, Stein MB, Kennedy CM, Archibald SL, Jernigan TL. Brain morphometry in female victims of intimate partner violence with and without posttraumatic stress disorder. Biological Psychiatry. 2002;2:1089–1101
  11. Folstein MF, Folstein SE, McHugh PR. Mini-Mental State: A practical method for grading the state of patients for the clinician. Journal of Psychiatric Research. 1975;12:189–198
  12. Frodl T, Meisenzahl EM, Zetzsche T, Born C, Groll C, Jager M, et al. Hippocampal changes in patients with a first episode of major depression. American Journal of Psychiatry. 2002;159:1112–1118
  13. Gilbertson MW, Shenton ME, Ciszewski A, Kasai K, Lasko NB, Orr SP, et al. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nature Neuroscience. 2002;5:1242–1247
  14. Goldberg J, True WR, Eisen SA, Henderson WG. A twin study of the effects of the Vietnam war on posttraumatic stress disorder. Journal of the American Medical Association. 1990;263:1227–1232
  15. Gregurek R, Pavic L, Vuger-Kovacic H, Potrebica S, Bitar Z, Kovacic D, et al. Increase of frequency of post-traumatic stress disorder in disabled war veterans during prolonged stay in a rehabilitation hospital. Croatian Medical Journal. 2001;42(2):161–164
  16. Gurvits TV, Shenton ME, Hokama H, Ohta H, Lasko NB, Gilbertson MW, et al. Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biological Psychiatry. 1996;40:1091–1099
  17. Hedges DW, Allen S, Tate DF, Thatcher GW, Miller MJ, Rice SA, et al. Reduced hippocampal volume in alcohol and substance naïve Vietnam combat veterans with posttraumatic stress disorder. Cognitive and Behavioral Neurology. 2003;16:219–224
  18. Henigsberg N, Folnegovic-Smalc V, Moro L. Stressor characteristics and post-traumatic stress disorder symptom dimensions in war victims. Croatian Medical Journal. 2001;42(5):543–550
  19. Hull AM. Neuroimaging findings in post-traumatic stress disorder. British Journal of Psychiatry. 2002;181:102–110
  20. Kitayama N, Viola Vaccarino V, Kutner M, Weiss P, Bremner JD. Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: a meta-analysis. Journal of Affective Disorders. 2005;88:79–86
  21. Kozaric-Kovacic D, Bajs M, Vidosic S, Matic A, Alegic-Karin A, Peraica T. Change of diagnosis of post-traumatic stress disorder related to compensation-seeking. Croatian Medical Journal. 2004;45(4):427–433
  22. Laakso MP, Vaurio O, Savolainen L, Repo E, Soininen H, Aronen HJ. A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism. Behavioral Brain Research. 2000;109:177–186
  23. Lang S, Javornik S, Bakalic S, Swedlund S, Ghidi V, Luetic V, et al. “Save Lives” Operation in liberated parts of Croatia in 1995: an emergency public health action to assist abandoned elderly population. Croatian Medical Journal. 1997;38:265–270
  24. Lindauer RJL, Vlieger EJ, Jalinka M, Olff M, Carlier IVE, Majoie CB, et al. Smaller hippocampal volume in Dutch police officers with posttraumatic stress disorder. Biological Psychiatry. 2004;56:356–363
  25. McEwen BS. The neurobiology of stress: from serendipity to clinical relevance. Brain Research. 2000;886:172–189
  26. McNaughton N. Cognitive dysfunction resulting from hippocampal hyperactivity—a possible cause of anxiety disorder. Pharmacology, Biochemistry and Behavior. 1997;56:603–611
  27. Nakano T, Wenner M, Inagaki M, Kugaya A, Akechi T, Matsuoka Y, et al. Relationship between distressing cancer-related recollections and hippocampal volume in cancer survivors. American Journal of Psychiatry. 2002;159:2089–2093
  28. Pederson CL, Maurer SH, Kaminski PL, Zander KA, Peters CM, Strokes-Crowe LA, et al. Hippocampal volume and memory performance in a community-based sample of women with posttraumatic stress disorder secondary to child abuse. Journal of Traumatic Stress. 2004;17:37–40
  29. Pedraza O, Bowers D, Gilmore R. Asymmetry of the hippocampus and amygdala in MRI volumetric measurements of normal adults. Journal of the International Neuropsychological Society. 2004;10:664–678
  30. Rauch SL, Whalen PJ, Shin LM, McInerney SC, Macklin ML, Lasko NB, et al. Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study. Biological Psychiatry. 2000;47(9):769–776
  31. Schuff N, Neylan TC, Lenoci MA, Du AT, Weiss DS, Marmar CR, et al. Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder. Biological Psychiatry. 2001;50:952–959
  32. Sheline YI, Gado MH, Kraemer HC. Untreated depression and hippocampal volume loss. American Journal of Psychiatry. 2003;160:1516–1518
  33. Shin LM, Whalen PJ, Pitman RK, Bush G, Macklin ML, Lasko NB, et al. An fMRI study of anterior cingulate function in posttraumatic stress disorder. Biological Psychiatry. 2001;50:932–942
  34. Shin LM, Shin PS, Heckers S, Krangel TS, Macklin ML, Orr SP, et al. Hippocampal function in posttraumatic stress disorder. Hippocampus. 2004;14:292–300
  35. Smith ME. Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: a meta-analysis of structural MRI studies. Hippocampus. 2005;15:798–807
  36. Stein MB, Koverola C, Hanna C, Torchia MG, McClarty B. Hippocampal volume in women victimized by childhood sexual abuse. Psychological Medicine. 1997;27:951–959
  37. Vermetten E, Vythilingam M, Southwick SM, Charney DS, Bremner JD. Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder. Biological Psychiatry. 2003;54:693–702
  38. Villarreal G, Hamilton DA, Petropoulos H, Driscoll I, Rowland LM, Griego JA, et al. Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder. Biological Psychiatry. 2002;52:119–125
  39. Wignall EL, Dickson JM, Vaughan P, Farrow TF, Wilkinson ID, Hunter MD, et al. Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorder. Biological Psychiatry. 2004;56:832–836
  40. Winter H, Irle E. Hippocampal volume in adult burn patients with and without posttraumatic stress disorder. American Journal of Psychiatry. 2004;161:2194–2200
  41. World Health Organization . International Classification of Diseases, 10th Revision, Research Version. Geneva: WHO; 1993;
  42. Yamasue H, Kasai K, Iwanami A, Ohtani T, Yamada H, Abe O, et al. Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic disorder due to terrorism. Proceedings of the National Academy of Sciences. 2003;100:9039–9043
  43. Yehuda R. Are glucocorticoids responsible for putative hippocampal damage in PTSD? How and when to decide. Hippocampus. 2001;11:85–89(discussion 82–84)
  44. Yehuda R. Post-traumatic stress disorder. New England Journal of Medicine. 2002;346(2):108–114
  45. Yehuda R, Giller EL, Southwick SM, Lowy MT, Mason JW. Hypothalamic–pituitary–adrenal dysfunction in posttraumatic stress disorder. Biological Psychiatry. 1991;30:1031–1048
  46. Yehuda R, Keefe RS, Harvey PD, Levengood RA, Gerber DK, Geni J, et al. Learning and memory in combat veterans with posttraumatic stress disorder. American Journal of Psychiatry. 1995;152:137–139
  47. Yucel K, Hakyemez B, Parlak M, Oygucu H. Morphometry of some elements of limbic system in normal population: a quantitative MRI study. Neuroanatomy. 2002;1:15–21

PII: S0925-4927(06)00129-6

doi: 10.1016/j.pscychresns.2006.08.005

Psychiatry Research: Neuroimaging
Volume 154, Issue 2 , Pages 191-198 , 28 February 2007