Psychiatry Research: Neuroimaging
Volume 154, Issue 2 , Pages 125-131 , 28 February 2007

Reduced midbrain serotonin transporter availability in drug-naïve patients with depression measured by SERT-specific [123I] nor-β-CIT SPECT imaging

  • Mikko Joensuu

      Affiliations

    • Department of Psychiatry, University of Kuopio, Kuopio, Finland
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, Kuopio University Hospital, P.O. Box 1777, FIN-70211 Kuopio, Finland. Tel.: +358 50 3576445; fax: +358 17 172966.
    • ,
  • Tommi Tolmunen

      Affiliations

    • Department of Psychiatry, University of Kuopio, Kuopio, Finland
    • ,
  • Pirjo I. Saarinen

      Affiliations

    • Department of Psychiatry, University of Kuopio, Kuopio, Finland
    • ,
  • Jari Tiihonen

      Affiliations

    • Department of Forensic Psychiatry, Niuvanniemi Hospital, Kuopio, Finland
    • ,
  • Jyrki Kuikka

      Affiliations

    • Department of Clinical Physiology and Nuclear Medicine, University of Kuopio, Kuopio, Finland
    • ,
  • Pasi Ahola

      Affiliations

    • Department of Psychiatry, University of Kuopio, Kuopio, Finland
    • ,
  • Ritva Vanninen

      Affiliations

    • Department of Radiology, University of Kuopio, Kuopio, Finland
    • ,
  • Johannes Lehtonen

      Affiliations

    • Department of Psychiatry, University of Kuopio, Kuopio, Finland

Received 2 September 2005 ,Revised 16 July 2006 ,Accepted 9 August 2006.

References 

  1. Acton PD, Kushner SA, Kung MP, Mozley PC, Plossl K, Kung HF. Simplified reference region model for the kinetic analysis of [99 mTc] TRODAT-1 binding to dopamine transporters in nonhuman primates using single-photon emission tomography. European Journal of Nuclear Medicine. 1990;26:518–526
  2. Annett M. The binomial distribution of right, mixed and left handedness. Quarterly Journal of Experimental Psychology. 1967;19:327–333
  3. Anguelova M, Benkelfat C, Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Molecular Psychiatry. 2003;8:574–591
  4. Barr CS, Newman TK, Shannon C, Parker C, Dvoskin RL, Becker ML, et al. Rearing condition and rh5-HTTLPR interact to influence limbic–hypothalamic–pituitary–adrenal axis response to stress in infant macaques. Biological Psychiatry. 2004;55:733–738
  5. Blakely RD, Ramamoorthy S, Schroeter S, Qian Y, Apparsundaram S, Galli A, et al. Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins. Biological Psychiatry. 1998;44:169–178
  6. Benedetti F, Colombo C, Serretti A, Lorenzi C, Pontiggia A, Barbini B, et al. Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Biological Psychiatry. 2003;54:687–692
  7. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386–389
  8. Dahlstrom M, Ahonen A, Ebeling H, Torniainen P, Heikkila J, Moilanen I. Elevated hypothalamic/midbrain serotonin (monoamine) transporter availability in depressive drug-naïve children and adolescents. Molecular Psychiatry. 2000;5:514–522
  9. Eggers B, Hermann W, Barthel H, Sabri O, Wagner A, Hesse S. The degree of depression in Hamilton rating scale is correlated with the density of presynaptic serotonin transporters in 23 patients with Wilson's disease. Journal of Neurology. 2003;250:576–580
  10. Glatz K, Mössner R, Heils A, Lesch KP. Glucocorticoid-regulated human serotonin transporter expression is modulated by the 5-HTT gene-promoter-linked polymorphic region. Journal of Neurochemistry. 2003;86:1072–1078
  11. Hamilton M. A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry. 1960;23:56–62
  12. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, et al. Serotonin transporter genetic variation and the response of the human amygdala. Science. 2002;5580:400–403
  13. Heinz A, Ragan P, Jones DW, Hommer D, Williams W, Knable MB, et al. Reduced serotonin transporters in alcoholism. American Journal of Psychiatry. 1998;155:1544–1549
  14. Hesse S, Barthel H, Hermann W, Murai T, Kluge R, Wagner A, et al. Regional serotonin transporter availability and depression are correlated in Wilson's disease. Journal of Neural Transmission. 2003;110:923–933
  15. Hesse S, Barthel H, Murai T, Müller U, Müller D, Seese A, et al. Is correction for age necessary in neuroimaging studies of the central serotonin transporter?. European Journal of Nuclear Medicine and Molecular Imaging. 2003;30:427–430
  16. Hiltunen J, Akerman KK, Kuikka JT, Bergstrom KA, Halldin C, Nikula T, et al. Iodine-123 labeled nor-beta-CIT as a potential tracer for serotonin transporter imaging in the human brain with single-photon emission tomography. European Journal of Nuclear Medicine. 1998;25:19–23
  17. Ichimiya T, Suhara T, Sudo Y, Okubo Y, Nakayama K, Nankai M, et al. Serotonin transporter binding in patients with mood disorders: a PET study with [11C](+)McN5652. Biological Psychiatry. 2002;51:715–722
  18. Inoue T, Xiao BL, Abekawa YK, Izumi T, Nakagawa S, Koyama T. Selective serotonin reuptake inhibitor reduces conditioned fear through its effect in the amygdala. European Journal of Pharmacology. 2004;497:311–316
  19. Kugaya A, Sanacora G, Staley JK, Malison RT, Bozkurt A, Khan S, et al. Brain serotonin transporter availability predicts treatment response to selective serotonin reuptake inhibitors. Biological Psychiatry. 2004;56:497–502
  20. Kuikka JT, Tenhunen-Eskelinen M, Jurvelin J, Kiilianen H. Physical performance of the Siemens MultiSPECT 3 gamma camera. Nuclear Medicine Communications. 1993;14:490–497
  21. Kuikka JT, Tammela L, Bergstrom KA, Karhunen L, Uusitupa M, Tiihonen J. Effects of ageing on serotonin transporters in healthy females. European Journal of Nuclear Medicine. 2001;28:911–913
  22. Kuikka JT, Tammela L, Karhunen L, Rissanen A, Bergstrom KA, Naukkarinen H, et al. Reduced serotonin transporter binding in binge eating women. Psychopharmacology. 2001;155:310–314
  23. Laasonen-Balk T, Viinamaki H, Kuikka JT, Husso-Saastamoinen M, Lehtonen J, Tiihonen J. 123I-beta-CIT binding and recovery from depression. A six-month follow-up study. European Archives of Psychiatry Clinical Neuroscience. 2004;254:152–155
  24. Lesch K-P, Bengel D, Heils A, Sabol Sz, Greenberg BD, Petri S, et al. Association of anxiety related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274:1527–1531
  25. Lira A, Zhou M, Castanon N, Ansorge MS, Gordon JA, Francis JH, et al. Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice. Biological Psychiatry. 2003;54:960–971
  26. Malison RT, Price LH, Berman R, van Dyck CH, Pelton GH, Carpenter L, et al. Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane and single photon emission computed tomography. Biological Psychiatry. 1998;44:1090–1098
  27. Montgomery SA, Åsberg M. A new depression scale designed to be sensitive to change. British Journal of Psychiatry. 1978;134:382–389
  28. Neumeister A, Pirker W, Willeit M, Praschak-Rieder N, Asenbaum S, Brücke T, et al. Seasonal variation of availability of serotonin transporter binding sites in healthy female subjects as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography. Biological Psychiatry. 2000;47:158–160
  29. Newberg A, Amsterdam J, Wintering N, Ploessl K, Swanson R, Shults J, et al. 123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study. Journal of Nuclear Medicine. 2005;46:973–977
  30. Pogarell O, Poepperl G, Mulert C, Hamann C, Sadowsky N, Riedel M, et al. SERT and DAT availabilities under citalopram treatment in obsessive–compulsive disorder (OCD). European Neuropsychopharmacology. 2005;15:521–524
  31. Siegle GJ, Steinhauer SR, Thase ME, Stenger VA, Carter CS. Can't shake that feeling: event related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biological Psychiatry. 2002;51:693–707
  32. Spitzer RL, Williams JBW, Gibbon M, First MB. The Structured Clinical Interview for DSM-III-R (SCID): I. History, rationale and description. Archives of General Psychiatry. 1992;49:624–629
  33. Staley JK, Sanacora G, Tamagnan G, Maciejewski PK, Malison RT, Berman RM, et al. Sex differences in diencephalon serotonin transporter availability in major depression. Biological Psychiatry. 2006;59:40–47
  34. Stutzmann GE, McEwen BS, Le Doux JE. Serotonin modulation of sensory inputs to lateral amygdala: dependency on corticosterone. Journal of Neuroscience. 1998;18:9529–9538
  35. Tauscher J, Pirker W, Willeit M, de Zwaan M, Bailer U, Neumeister A, et al. [123I]β-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa. Biological Psychiatry. 2001;49:326–332
  36. Talaraich J, Tournoux P. Referentially Oriented Cerebral MRI Anatomy. New York: Thieme; 1993;
  37. Tolmunen T, Joensuu M, Saarinen PI, Mussalo H, Ahola P, Vanninen R, et al. Elevated midbrain serotonin transporter availability in mixed mania: a case report. BMC Psychiatry. 2004;4:27
  38. van Dyck CH, Malison RT, Seibyl JP, Laruelle M, Klumpp H, Zoghbi SS, et al. Age-related decline in central serotonin transporter availability with [123I]beta-CIT SPECT. Neurobiology of Aging. 2000;21:497–501
  39. Viinamäki H, Kuikka J, Tiihonen J, Lehtonen J. Change in monoamine transporter density related to clinical recovery: a case–control study. Nordic Journal of Psychiatry. 1998;52:39–44
  40. Willeit M, Praschack-Rieder N, Neumeister A, Pirker W, Asenbaum S, Vitouch O, et al. [123I]beta-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug free depressed patients with seasonal affective disorder. Biological Psychiatry. 2000;47:482–489
  41. Yu YW-Y, Tsai S-J, Chen T-J, Lin C-H, Hong C-J. Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorder. Molecular Psychiatry. 2002;7:1115–1119

PII: S0925-4927(06)00125-9

doi: 10.1016/j.pscychresns.2006.08.001

Psychiatry Research: Neuroimaging
Volume 154, Issue 2 , Pages 125-131 , 28 February 2007

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