Psychiatry Research: Neuroimaging
Volume 154, Issue 1 , Pages 93-98, 15 January 2007

Amygdala reactivity to emotional faces at high and low intensity in generalized social phobia: A 4-Tesla functional MRI study

Brain Imaging and Emotions Laboratory, Department of Psychiatry, Biological Sciences Division and the Pritzker School of Medicine, and the Center for Cognitive and Social Neuroscience, University of Chicago, Chicago, IL, USA

Received 23 March 2006; received in revised form 6 May 2006; accepted 23 May 2006.

Abstract 

Using functional magnetic resonance imaging, we measured amygdala reactivity to faces varying on emotional intensity in subjects with generalized social phobia (GSP) and matched healthy controls, and observed greater bilateral activation to high (vs. low) intensity expressions in the phobic group, suggesting that more arousing social–emotional cues contribute to limbic hyperactivity in GSP.

Keywords: Functional magnetic resonance imaging, Social phobia, Amygdala

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PII: S0925-4927(06)00096-5

doi:10.1016/j.pscychresns.2006.05.004

Psychiatry Research: Neuroimaging
Volume 154, Issue 1 , Pages 93-98, 15 January 2007

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