Psychiatry Research: Neuroimaging
Volume 148, Issue 2 , Pages 185-193 , 1 December 2006

A PET study of 5-HT1A receptors at different phases of the menstrual cycle in women with premenstrual dysphoria

  • Hristina Jovanovic

      Affiliations

    • Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    • ,
  • Åsta Cerin

      Affiliations

    • Karolinska Institutet, Department of Woman and Child Health, Stockholm, Sweden
    • ,
  • Per Karlsson

      Affiliations

    • Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    • ,
  • Johan Lundberg

      Affiliations

    • Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    • ,
  • Christer Halldin

      Affiliations

    • Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    • ,
  • Anna-Lena Nordström

      Affiliations

    • Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    • Corresponding Author InformationCorresponding author. Department of Clinical Neuroscience, Psychiatry Section, Karolinska Psychiatric Center, Karolinska Hospital, SE-171 76 Stockholm, Sweden. Tel.: +46 8 517 744 65; fax: +46 8 517 717 53.

Received 24 January 2006 ,Revised 19 April 2006 ,Accepted 5 May 2006.

References 

  1. American Psychiatric Association . Premenstrual dysphoric disorder. In: Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: APA; 1994;
  2. Angst J, Sellaro R, Merikangas KR, Endicott J. The epidemiology of perimenstrual psychological symptoms. Acta Psychiatrica Scandinavica. 2001;104:110–116
  3. Ashby CR, Carr LA, Cook CL, Steptoe MM, Franks DD. Alteration of 5-HT uptake by plasma fractions in the premenstrual syndrome. Journal of Neural Transmission. General Section. 1990;79:41–50
  4. Backstrom T, Sanders D, Leask R, Davidson D, Warner P, Bancroft J. Mood, sexuality, hormones, and the menstrual cycle: II. Hormone levels and their relationship to the premenstrual syndrome. Psychosomatic Medicine. 1983;45:503–507
  5. Bancroft J, Cook A, Davidson D, Bennie J, Goodwin G. Blunting of neuroendocrine responses to infusion of l-tryptophan in women with perimenstrual mood change. Psychological Medicine. 1991;21:305–312
  6. Baumann B, Bielau H, Krell D, Agelink MW, Diekmann S, Wurthmann C, et al. Circumscribed numerical deficit of dorsal raphe neurons in mood disorders. Psychological Medicine. 2002;32:93–103
  7. Bergstrom M, Boethius J, Eriksson L, Greitz T, Ribbe T, Widen L. Head fixation device for reproducible position alignment in transmission CT and positron emission tomography. Journal of Computer Assisted Tomography. 1981;5:136–141
  8. Biegon A, Bercovitz H, Samuel D. Serotonin receptor concentration during the estrous cycle of the rat. Brain Research. 1980;187:221–225
  9. Cleare AJ, Bond AJ. Ipsapirone challenge in aggressive men shows an inverse correlation between 5-HT1A receptor function and aggression. Psychopharmacology (Berl). 2000;148:344–349
  10. Coccaro EF, Gabriel S, Siever LJ. Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans. Psychopharmacology Bulletin. 1990;26:393–405
  11. Coccaro EF, Kavoussi RJ, Hauger RL. Physiological responses to d-fenfluramine and ipsapirone challenge correlate with indices of aggression in males with personality disorder. International Clinical Psychopharmacology. 1995;10:177–179
  12. Davidson RJ, Lewis DA, Alloy LB, Amaral DG, Bush G, Cohen JD, et al. Neural and behavioral substrates of mood and mood regulation. Biological Psychiatry. 2002;52:478–502
  13. Dimmock PW, Wyatt KM, Jones PW, O'Brien PM. Efficacy of selective serotonin-reuptake inhibitors in premenstrual syndrome: a systematic review. Lancet. 2000;356:1131–1136
  14. Drevets WC, Frank E, Price JC, Kupfer DJ, Holt D, Greer PJ, et al. PET imaging of serotonin 1A receptor binding in depression. Biological Psychiatry. 1999;46:1375–1387
  15. Eriksson E, Hedberg MA, Andersch B, Sundblad C. The serotonin reuptake inhibitor paroxetin is superior to the noradrenaline reuptake inhibitor maprotiline in the treatment of premenstrual syndrome. Neuropsychopharmacology. 1995;12:167–176
  16. Farde L, Ito H, Swahn CG, Pike VW, Halldin C. Quantitative analyses of carbonyl-carbon-11-WAY-100635 binding to central 5-hydroxytryptamine-1A receptors in man. Journal of Nuclear Medicine. 1998;39:1965–1971
  17. Filicori M, Butler JP, Crowley WF. Neuroendocrine regulation of the corpus luteum in the human. Evidence for pulsatile progesterone secretion. Journal of Clinical Investigation. 1984;73:1638–1647
  18. Filicori M, Santoro N, Merriam GR, Crowley WF. Characterization of the physiological pattern of episodic gonadotropin secretion throughout the human menstrual cycle. Journal of Clinical Endocrinolology and Metabolism. 1986;62:1136–1144
  19. FitzGerald M, Malone KM, Li S, Harrison WM, McBride PA, Endicott J, et al. Blunted serotonin response to fenfluramine challenge in premenstrual dysphoric disorder. American Journal of Psychiatry. 1997;154:556–558
  20. Fludder JM, Tonge SR. Proceedings: variations in the concentrations of monoamines and their metabolites in eight regions of rat brain during the oestrous cycle: a basis for interactions between hormones and psychotropic drugs. Journal of Pharmacy and Pharmacology. 1975;27:(39 pp.)
  21. Flugge G, Pfender D, Rudolph S, Jarry H, Fuchs E. 5HT1A-receptor binding in the brain of cyclic and ovariectomized female rats. Journal of Neuroendocrinology. 1999;11:243–249
  22. Graze KK, Nee J, Endicott J. Premenstrual depression predicts future major depressive disorder. Acta Psychiatrica Scandinavica. 1990;81:201–205
  23. Gundlah C, Simon LD, Auerbach SB. Differences in hypothalamic serotonin between estrous phases and gender: an in vivo microdialysis study. Brain Research. 1998;785:91–96
  24. Gunn RN, Sargent PA, Bench CJ, Rabiner EA, Osman S, Pike VW, et al. Tracer kinetic modeling of the 5-HT1A receptor ligand [carbonyl-11C]WAY-100635 for PET. Neuroimage. 1998;8:426–440
  25. Gur RC, Gunning-Dixon F, Bilker WB, Gur RE. Sex differences in temporo-limbic and frontal brain volumes of healthy adults. Cerebral Cortex. 2002;12:998–1003
  26. Halbreich U. Premenstrual dysphoric disorders, anxiety, and depressions: vulnerability traits or comorbidity. Archive of General Psychiatry. 1995;52:606
  27. Halbreich U, Endicott J. Relationship of dysphoric premenstrual changes to depressive disorders. Acta Psychiatrica Scandinavica. 1985;71:331–338
  28. Hall H, Lundkvist C, Halldin C, Farde L, Pike VW, McCarron JA, et al. Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [3H]WAY-100635 and [11C]way-100635. Brain Research. 1997;745:96–108
  29. Harrison, W.M., Rabkin, J.G., Endicott, J., 1985. Psychiatric evaluation of premenstrual changes. Psychosomatics 26, 789–792, 795, 798–789.
  30. Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage. 1996;4:153–158
  31. Landen M, Eriksson E. How does premenstrual dysphoric disorder relate to depression and anxiety disorders?. Depression and Anxiety. 2003;17:122–129
  32. Maswood S, Truitt W, Hotema M, Caldarola-Pastuszka M, Uphouse L. Estrous cycle modulation of extracellular serotonin in mediobasal hypothalamus: role of the serotonin transporter and terminal autoreceptors. Brain Research. 1999;831:146–154
  33. Meltzer CC, Drevets WC, Price JC, Mathis CA, Lopresti B, Greer PJ, et al. Gender-specific aging effects on the serotonin 1A receptor. Brain Research. 2001;895:9–17
  34. Moses EL, Drevets WC, Smith G, Mathis CA, Kalro BN, Butters MA, et al. Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study. Biological Psychiatry. 2000;48:854–860
  35. Parsey RV, Slifstein M, Hwang DR, Abi-Dargham A, Simpson N, Mawlawi O, et al. Validation and reproducibility of measurement of 5-HT1A receptor parameters with [carbonyl-11C]WAY-100635 in humans: comparison of arterial and reference tissue input functions. Journal of Cerebral Blood Flow and Metabolism. 2000;20:1111–1133
  36. Parsey RV, Oquendo MA, Simpson NR, Ogden RT, Van Heertum R, Arango V, et al. Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635. Brain Research. 2002;954:173–182
  37. Rapkin AJ, Buckman TD, Sutphin MS, Chang LC, Reading AE. Platelet monoamine oxidase B activity in women with premenstrual syndrome. American Journal of Obstetrics and Gynecology. 1988;159:1536–1540
  38. Roland PE, Zilles K. Brain atlases—a new research tool. Trends in Neuroscience. 1994;17:458–467
  39. Rossmanith WG, Laughlin GA, Mortola JF, Johnson ML, Veldhuis JD, Yen SS. Pulsatile cosecretion of estradiol and progesterone by the midluteal phase corpus luteum: temporal link to luteinizing hormone pulses. Journal of Clinical Endocrinology and Metabolism. 1990;70:990–995
  40. Rubinow DR, Hoban MC, Grover GN, Galloway DS, Roy-Byrne P, Andersen R, et al. Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects. American Journal of Obstetrics and Gynecology. 1988;158:5–11
  41. Sargent PA, Kjaer KH, Bench CJ, Rabiner EA, Messa C, Meyer J, et al. Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Archive of General Psychiatry. 2000;57:174–180
  42. Schmidt PJ, Nieman LK, Danaceau MA, Adams LF, Rubinow DR. Differential behavioral effects of gonadal steroids in women with and in those without premenstrual syndrome. New England Journal of Medicine. 1998;338:209–216
  43. Slater P, Doyle CA, Deakin JF. Abnormal persistence of cerebellar serotonin-1A receptors in schizophrenia suggests failure to regress in neonates. Journal of Neural Transmission. 1998;105:305–315
  44. Smith CE, Ware CJ, Cowen PJ. Pindolol decreases prolactin and growth hormone responses to intravenous l-tryptophan. Psychopharmacology. 1991;103:140–142
  45. Steege JF, Stout AL, Knight DL, Nemeroff CB. Reduced platelet tritium-labeled imipramine binding sites in women with premenstrual syndrome. American Journal of Obstetrics and Gynecology. 1992;167:168–172
  46. Stockmeier CA, Shapiro LA, Dilley GE, Kolli TN, Friedman L, Rajkowska G. Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression—postmortem evidence for decreased serotonin activity. Journal of Neuroscience. 1998;18:7394–7401
  47. Wienhard K, Dahlbom M, Eriksson L, Michel C, Bruckbauer T, Pietrzyk U, et al. The ECAT EXACT HR: performance of a new high resolution positron scanner. Journal of Computer Assisted Tomography. 1994;18:110–118
  48. Yatham LN. Is 5HT1A receptor subsensitivity a trait marker for late luteal phase dysphoric disorder? A pilot study. Canadian Journal of Psychiatry. 1993;38:662–664
  49. Yonkers KA, Halbreich U, Freeman E, Brown C, Endicott J, Frank E, et al. Symptomatic improvement of premenstrual dysphoric disorder with sertraline treatment. A randomized controlled trial. Sertraline Premenstrual Dysphoric Collaborative Study Group. Journal of the American Medical Association. 1997;278:983–988

PII: S0925-4927(06)00090-4

doi: 10.1016/j.pscychresns.2006.05.002

Psychiatry Research: Neuroimaging
Volume 148, Issue 2 , Pages 185-193 , 1 December 2006

Article Tools

* Image Usage & Resolution