Psychiatry Research: Neuroimaging
Volume 154, Issue 1 , Pages 31-40 , 15 January 2007

Brain activation patterns during a selective attention test — a functional MRI study in healthy volunteers and unmedicated patients during an acute episode of schizophrenia

  • Elisabeth M. Weiss

      Affiliations

    • Department of General Psychiatry, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +43 512 504 23636; fax: +43 512 504 23628.
  • ,
  • Christian Siedentopf

      Affiliations

    • Department of Magnetic Resonance Imaging, Medical University Innsbruck, Austria
  • ,
  • Stefan Golaszewski

      Affiliations

    • Department of Magnetic Resonance Imaging, Medical University Innsbruck, Austria
  • ,
  • Felix M. Mottaghy

      Affiliations

    • Department of Nuclear Medicine, University of Ulm, Germany
  • ,
  • Alex Hofer

      Affiliations

    • Department of Biological Psychiatry, Medical University Innsbruck, Austria
  • ,
  • Christian Kremser

      Affiliations

    • Department of Magnetic Resonance Imaging, Medical University Innsbruck, Austria
  • ,
  • Stefan Felber

      Affiliations

    • Department of Magnetic Resonance Imaging, Medical University Innsbruck, Austria
  • ,
  • W. Wolfgang Fleischhacker

      Affiliations

    • Department of Biological Psychiatry, Medical University Innsbruck, Austria

Received 2 January 2006 ,Revised 24 March 2006 ,Accepted 22 April 2006.

References 

  1. Barch DM, Carter CS, Perlstein W, Baird J, Cohen JD, Schooler N. Increased Stroop facilitation effects in schizophrenia are not due to increased automatic spreading activation. Schizophrenia Research. 1999;39:51–64
  2. Barch DM, Carter CS, Braver TS, Sabb FW, MacDonald A, Noll DC, et al. Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Archives of General Psychiatry. 2001;58:280–288
  3. Brett M, Christoff R, Cusack J, Lancaster J. Using the Talairach atlas with the MNI template. Neuroimage. 2001;13:85
  4. Callicott JH, Ramsey NF, Tallent K, Bertolino A, Knable MB, Coppola R, et al. Functional magnetic resonance imaging brain mapping in psychiatry: methodological issues illustrated in a study of working memory in schizophrenia. Neuropsychopharmacology. 1998;18:186–196
  5. Callicott JH, Bertolino A, Mattay VS, Langheim FJ, Duyn J, Coppola R, et al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cerebral Cortex. 2000;10:1078–1092
  6. Carter CS, Perlstein W, Ganguli R, Brar J, Mintun M, Cohen JD. Functional hypofrontality and working memory dysfunction in schizophrenia. American Journal of Psychiatry. 1998;155:1285–1287
  7. Cohen JD, Servan S. Context, cortex, and dopamine: a connectionist approach to behavior and biology in schizophrenia. Psychological Review. 1992;99:45–77
  8. Curtis VA, Bullmore ET, Brammer MJ, Wright IC, Williams SC, Morris RG, et al. Attenuated frontal activation during a verbal fluency task in patients with schizophrenia. American Journal of Psychiatry. 1998;155:1056–1063
  9. Fletcher PC, McKenna PJ, Frith C, Grasby PM, Friston KJ, Dolan RJ. Brain activations in schizophrenia during a graded memory task studied with functional neuroimaging. Archives of General Psychiatry. 1998;55:1001–1008
  10. Friston KJ, Ashburner J, Frith C, Poline JB, Heather JD, Frackowiak RSJ. Spatial registration and normalisation of images. Human Brain Mapping. 1995;
  11. Frith CD, Friston KJ, Herold S, Silbersweig D, Fletcher P, Cahill C, et al. Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. British Journal of Psychiatry. 1995;167:343–349
  12. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998;12:426–445
  13. Honey GD, Bullmore ET, Soni W, Varatheesan M, Williams SC, Sharma T. Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical antipsychotic drugs in patients with schizophrenia. In: Proceedings of the National Academy of Sciences of the United States of America. vol. 96:1999;p. 13432–13437
  14. Jones HM, Brammer MJ, O'Toole M, Taylor T, Ohlsen RI, Brown RG, et al. Cortical effects of quetiapine in first episode schizophrenia: a preliminary functional magnetic resonance imaging study. Biological Psychiatry. 2004;56:938–942
  15. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin. 1987;13:261–276
  16. Manoach DS, Press DZ, Thangaraj V, Searl MM, Goff DC, Halpern E, et al. Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biological Psychiatry. 1999;45:1128–1137
  17. Manoach DS, Gollub RL, Benson ES, Searl MM, Goff DC, Halpern E, et al. Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biological Psychiatry. 2000;48:99–109
  18. Manoach DS, Greve DN, Lindgren KA, Dale AM. Identifying regional activity associated with temporally separated components of working memory using event related functional MRI. Neuroimage. 2003;20:1670–1684
  19. Mellers JD, Adachi N, Takei N, Cluckie A, Toone BK, Lishman WA. SPET study of verbal fluency in schizophrenia and epilepsy. British Journal of Psychiatry. 1998;173:69–74
  20. Meltzer HY, McGurk SR. The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia. Schizophrenia Bulletin. 1999;25:233–255
  21. Oldfield RC. The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia. 1971;9:97–113
  22. Perlstein WM, Carter CS, Noll DC, Cohen JD. Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. American Journal of Psychiatry. 2001;158:1105–1113
  23. Poline JB, Worsley KJ, Holmes AP, Frackowiak RS, Friston KJ. Estimating smoothness in statistical parametric maps: variability of p values. Journal of Computer Assisted Tomography. 1995;19:788–796
  24. Price CJ, Friston KJ. Scanning patients with tasks they can perform. Human Brain Mapping. 1999;8:102–108
  25. Ramsey NF, Koning HA, Welles P, Cahn W, Van Der Linden JA, Kahn RS. Excessive recruitment of neural systems subserving logical reasoning in schizophrenia. Brain. 2002;125:1793–1807
  26. Rund BR, Borg NE. Cognitive deficits and cognitive training in schizophrenic patients: a review. Acta Psychiatrica Scandinavica. 1999;100:85–95
  27. Sharma T. Cognitive effects of conventional and atypical antipsychotics in schizophrenia. British Journal of Psychiatry (Suppl.). 1999;38:44–51
  28. Stevens AA, Goldman-Rakic PS, Gore JC, Fulbright RK, Wexler BE. Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging. Archives of General Psychiatry. 1998;55:1097–1103
  29. Talairach J, Tournoux P. A Co-Planar Stereotaxic Atlas of a Human Brain. Stuttgart: Thieme; 1988;
  30. Weinberger DR, Berman KF. Prefrontal function in schizophrenia: confounds and controversies. Philosophical Transactions of the Royal Society of London: B. Biological Sciences. 1996;351:1495–1503
  31. Weinberger DR, Berman KF, Illowsky BP. Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia: III. A new cohort and evidence for a monoaminergic mechanism. Archives of General Psychiatry. 1988;45:609–615
  32. Weinberger DR, Berman KF, Suddath R, Torrey EF. Evidence of dysfunction of a prefrontal–limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins. American Journal of Psychiatry. 1992;149:890–897
  33. Weiss E, Kemmler G, Fleischhacker WW. Improvement of cognitive dysfunction after treatment with second-generation antipsychotics. Archives of General Psychiatry. 2002;59:572–573
  34. Weiss EM, Bilder RM, Fleischhacker WW. The effects of second-generation antipsychotics on cognitive functioning and psychosocial outcome in schizophrenia. Psychopharmacology. 2002;162:11–17
  35. Weiss EM, Golaszewski S, Mottaghy FM, Hofer A, Hausmann A, Kemmler G, et al. Brain activation patterns during a selective attention test—a functional MRI study in healthy volunteers and patients with schizophrenia. Psychiatry Research. Neuroimaging. 2003;123:1–15
  36. Woodruff PW, Wright IC, Bullmore ET, Brammer M, Howard RJ, Williams SC, et al. Auditory hallucinations and the temporal cortical response to speech in schizophrenia: a functional magnetic resonance imaging study. American Journal of Psychiatry. 1997;154:1676–1682
  37. Yurgelun-Todd DA, Waternaux CM, Cohen BM, Gruber SA, English CD, Renshaw PF. Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. American Journal of Psychiatry. 1996;153:200–205

PII: S0925-4927(06)00070-9

doi: 10.1016/j.pscychresns.2006.04.009

Psychiatry Research: Neuroimaging
Volume 154, Issue 1 , Pages 31-40 , 15 January 2007