Psychiatry Research: Neuroimaging
Volume 154, Issue 1 , Pages 41-48 , 15 January 2007

Normal pituitary volumes in chronic schizophrenia

  • Kalliopi Tournikioti

      Affiliations

    • Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
  • ,
  • Michele Tansella

      Affiliations

    • Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    • Verona-Udine Brain Imaging and Neuropsychology Program, InterUniversity Center for Behavioral Neurosciences, University of Verona, Verona, Italy
  • ,
  • Cinzia Perlini

      Affiliations

    • Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    • Verona-Udine Brain Imaging and Neuropsychology Program, InterUniversity Center for Behavioral Neurosciences, University of Verona, Verona, Italy
  • ,
  • Gianluca Rambaldelli

      Affiliations

    • Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    • Verona-Udine Brain Imaging and Neuropsychology Program, InterUniversity Center for Behavioral Neurosciences, University of Verona, Verona, Italy
  • ,
  • Roberto Cerini

      Affiliations

    • Department of Morphological and Biomedical Sciences, Section of Radiology, University of Verona, Verona, Italy
  • ,
  • Amelia Versace

      Affiliations

    • Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    • Verona-Udine Brain Imaging and Neuropsychology Program, InterUniversity Center for Behavioral Neurosciences, University of Verona, Verona, Italy
  • ,
  • Nicola Andreone

      Affiliations

    • Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    • Verona-Udine Brain Imaging and Neuropsychology Program, InterUniversity Center for Behavioral Neurosciences, University of Verona, Verona, Italy
  • ,
  • Nicola Dusi

      Affiliations

    • Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    • Verona-Udine Brain Imaging and Neuropsychology Program, InterUniversity Center for Behavioral Neurosciences, University of Verona, Verona, Italy
  • ,
  • Matteo Balestrieri

      Affiliations

    • Verona-Udine Brain Imaging and Neuropsychology Program, InterUniversity Center for Behavioral Neurosciences, University of Udine, Udine, Italy
    • Department of Pathology and Clinical and Experimental Medicine, Section of Psychiatry, University of Udine, Udine, Italy
  • ,
  • Roberto Malagò

      Affiliations

    • Department of Morphological and Biomedical Sciences, Section of Radiology, University of Verona, Verona, Italy
  • ,
  • Anna Gasparini

      Affiliations

    • Department of Morphological and Biomedical Sciences, Section of Radiology, University of Verona, Verona, Italy
  • ,
  • Paolo Brambilla

      Affiliations

    • Verona-Udine Brain Imaging and Neuropsychology Program, InterUniversity Center for Behavioral Neurosciences, University of Udine, Udine, Italy
    • Department of Pathology and Clinical and Experimental Medicine, Section of Psychiatry, University of Udine, Udine, Italy
    • Corresponding Author InformationCorresponding author. Dipartimento di Patologia e Medicina Clinica e Sperimentale, Cattedra di Psichiatria, Policlinico Universitario, Via Colugna 50, 33100 Udine, Italy. Tel.: +39 0432 55.9494; fax: +39 0432 54.5526.

Received 2 February 2006 ,Revised 30 March 2006 ,Accepted 2 April 2006.

References 

  1. Amaddeo F, Beecham J, Bonizzato P, Fenyo A, Knapp M, Tansella M. The use of a case register to evaluate the costs of psychiatric care. Acta Psychiatrica Scandinavica. 1997;95:189–198
  2. Banki CM, Bissette G, Arato M, O'Connor L, Nemeroff CB. CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia. American Journal of Psychiatry. 1987;144:873–877
  3. Chen HH, Nicoletti M, Sanches M, Hatch JP, Sassi RB, Axelson D, et al. Normal pituitary volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging study. Depression and Anxiety. 2004;20:182–186
  4. Coryell W, Tsuang D. Hypothalamic–pituitary–adrenal axis hyperactivity and psychosis: recovery during an 8-year follow-up. American Journal of Psychiatry. 1992;149:1033–1039
  5. Cox TD, Elster AD. Normal pituitary gland: changes in shape, size, and signal intensity during the 1st year of life at MR imaging. Radiology. 1991;179:721–724
  6. Dinc H, Esen F, Demirci A, Sari A, Resit Gumele H. Pituitary dimensions and volume measurements in pregnancy and post partum, MR assessment. Acta Radiologica. 1998;39:64–69
  7. Doraiswamy PM, Potts JM, Axelson DA, Husain MM, Lurie SN, Na C, et al. MR assessment of pituitary gland morphology in healthy volunteers: age- and gender-related differences. AJNR American Journal of Neuroradiology. 1992;13:1295–1299
  8. Elster AD. Modern imaging of the pituitary. Radiology. 1993;187:1–14
  9. Elster AD, Chen MY, Williams DW, Key LL. Pituitary gland: MR imaging of physiologic hypertrophy in adolescence. Radiology. 1990;174:681–685
  10. Elster AD, Sanders TG, Vines FS, Chen MY. Size and shape of the pituitary gland during pregnancy and post partum: measurement with MR imaging. Radiology. 1991;181:531–535
  11. Fujisawa I, Asato R, Nishimura K, Togashi K, Itoh K, Nakano Y, et al. Anterior and posterior lobes of the pituitary gland: assessment by 1.5 T MR imaging. Journal of Computer Assisted Tomography. 1987;11:214–220
  12. Fujisawa I, Nishimura K, Asato R, Togashi K, Itoh K, Noma S, et al. Posterior lobe of the pituitary in diabetes insipidus: MR findings. Journal of Computer Assisted Tomography. 1987;11:221–225
  13. Garner B, Pariante CM, Wood SJ, Velakoulis D, Phillips L, Soulsby B, et al. Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosis. Biologial Psychiatry. 2005;58:417–423
  14. Häfner H. Schizophrenia: still Kraepelin's Dementia Praecox?. Epidemiologia e Psichiatria Sociale. 2004;13:99–112
  15. Harrison G. Trajectories of psychosis: towards a new social biology of schizophrenia. Epidemiologia e Psichiatria Sociale. 2004;13:152–157
  16. Herz MI, Fava GA, Molnar G, Edwards L. The dexamethasone suppression test in newly hospitalized schizophrenic patients. American Journal of Psychiatry. 1985;142:127–129
  17. Ismail K, Murray RM, Wheeler MJ, O'Keane V. The dexamethasone suppression test in schizophrenia. Psychological Medicine. 1998;28:311–317
  18. Kapur S, Langlois X, Vinken P, Megens AA, De Coster R, Andrews JS. The differential effects of atypical antipsychotics on prolactin elevation are explained by their differential blood–brain disposition: a pharmacological analysis in rats. Journal of Pharmacology and Experimental Therapeutics. 2002;302:1129–1134
  19. Keshavan MS, Diwadkar VA, Rosenberg DR. Developmental biomarkers in schizophrenia and other psychiatric disorders: common origins, different trajectories?. Epidemiologia e Psichiatria Sociale. 2005;14:188–193
  20. Lammers CH, Garcia-Borreguero D, Schmider J, Gotthardt U, Dettling M, Holsboer F, et al. Combined dexamethasone/corticotropin-releasing hormone test in patients with schizophrenia and in normal controls: II. Biological Psychiatry. 1995;38:803–807
  21. Leucht S, Kane JM, Kissling W, Hamann J, Etschel E, Engel R. Clinical implications of Brief Psychiatric Rating Scale scores. British Journal of Psychiatry. 2005;187:366–371
  22. Lurie SN, Doraiswamy PM, Husain MM, Boyko OB, Ellinwood EH, Figiel GS, et al. In vivo assessment of pituitary gland volume with magnetic resonance imaging: the effect of age. Journal of Clinical Endocrinology and Metabolism. 1990;71:505–508
  23. MacMaster FP, Kusumakar V. MRI study of the pituitary gland in adolescent depression. Journal of Psychiatric Research. 2004;38:231–236
  24. MacMaster FP, Russell A, Mirza Y, Keshavan MS, Banerjee SP, Bhandari R, et al. Pituitary volume in pediatric obsessive-compulsive disorder. Biological Psychiatry. 2006;59:252–257
  25. Meltzer HY. Clinical studies on the mechanism of action of clozapine: the dopamine–serotonin hypothesis of schizophrenia. Psychopharmacology. 1989;99:S18–S27
  26. Munck A, Guyre PM, Holbrook NJ. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocrine Reviews. 1984;5:25–44
  27. Oliveira MC, Messinger HP, Tannhauser M, Barbosa-Coutinho L. Chronic effect of antidopaminergic drugs or estrogen on male Wistar rat lactotrophs and somatotrophs. Brazilian Journal of Medical and Biological Research. 1999;32:1561–1564
  28. Pariante CM, Dazzan P, Danese A, Morgan KD, Brudaglio F, Morgan C, et al. Increased pituitary volume in antipsychotic-free and antipsychotic-treated patients of the AEsop first-onset psychosis study. Neuropsychopharmacology. 2005;30:1923–1931
  29. Pariante CM, Vassilopoulou K, Velakoulis D, Phillips L, Soulsby B, Wood SJ, et al. Pituitary volume in psychosis. British Journal of Psychiatry. 2004;185:5–10
  30. Ryan MC, Collins P, Thakore JH. Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia. American Journal of Psychiatry. 2003;160:284–289
  31. Ryan MC, Sharifi N, Condren R, Thakore JH. Evidence of basal pituitary–adrenal overactivity in first episode, drug naive patients with schizophrenia. Psychoneuroendocrinology. 2004;29:1065–1070
  32. Sachar EJ, Kanter SS, Buie D, Engle R, Mehlman R. Psychoendocrinology of ego disintegration. American Journal of Psychiatry. 1970;126:1067–1078
  33. Sala M, Perez J, Soloff P, Ucelli di Nemi S, Caverzasi E, Soares JC, et al. Stress and hippocampal abnormalities in psychiatric disorders. European Neuropsychopharmacology. 2004;14:393–405
  34. Sassi RB, Nicoletti M, Brambilla P, Harenski K, Mallinger AG, Frank E, et al. Decreased pituitary volume in patients with bipolar disorder. Biological Psychiatry. 2001;50:271–280
  35. Suzuki M, Takashima T, Kadoya M, Konishi H, Kameyama T, Yoshikawa J, et al. Height of normal pituitary gland on MR imaging: age and sex differentiation. Journal of Computer Assisted Tomography. 1990;14:36–39
  36. Takano K, Utsunomiya H, Ono H, Ohfu M, Okazaki M. Normal development of the pituitary gland: assessment with three-dimensional MR volumetry. AJNR American Journal of Neuroradiology. 1999;20:312–315
  37. Tandon R, Halbriech U. The second-generation ‘atypical’ antipsychotics: similar improved efficacy but different neuroendocrine side effects. Psychoneuroendocrinology. 2003;28:1–7Suppl 1
  38. Tandon R, Mazzara C, DeQuardo J, Craig KA, Meador-Woodruff JH, Goldman R, et al. Dexamethasone suppression test in schizophrenia: relationship to symptomatology, ventricular enlargement, and outcome. Biological Psychiatry. 1991;29:953–964
  39. Tansella M, Amaddeo F, Burti L, Lasalvia A, Ruggeri M. Evaluating a community-based mental health service focusing on severe mental illness. The Verona experience. Acta Psychiatrica Scandinavica Supplementum. 2006;429:90–94
  40. Ventura J, Nuechterlein KH, Subotnik KL, Gutkind D, Gilbert EA. Symptom dimensions in recent-onset schizophrenia and mania: a principal components analysis of the 24-item Brief Psychiatric Rating Scale. Psychiatry Research. 2000;97:129–135
  41. Walder DJ, Walker EF, Lewine RJ. Cognitive functioning, cortisol release, and symptom severity in patients with schizophrenia. Biological Psychiatry. 2000;48:1121–1132
  42. Wik G. Effects of neuroleptic treatment on cortisol and 3-methoxy-4-hydroxyphenylethyl glycol levels in blood. Journal of Endocrinology. 1995;144:425–429
  43. Wilson JD, Foster JW, Knonemberg HM, Larsen PR. Willians Textbook of Endocrinology. Philadelphia: W.B. Saunders; 1998;
  44. Wing JK, Babor T, Brugha T, Burke J, Cooper JE, Giel R, et al. SCAN. Schedules for Clinical Assessment in Neuropsychiatry. Archives of General Psychiatry. 1990;47:589–593
  45. World Health Organization . Schedules for Clinical Assessment in Neuropsychiatry. Geneva: WHO; 1992;
  46. World Health Organization . Schede di valutazione clinica in neuropsichiatria. SCAN 2.1.. Roma: Il Pensiero Scientifico Editore; 1996;

PII: S0925-4927(06)00066-7

doi: 10.1016/j.pscychresns.2006.04.004

Psychiatry Research: Neuroimaging
Volume 154, Issue 1 , Pages 41-48 , 15 January 2007