Psychiatry Research: Neuroimaging
Volume 147, Issue 2 , Pages 213-220 , 30 October 2006

Orbitofrontal correlates of aggression and impulsivity in psychiatric patients

  • Ami Sheth Antonucci

      Affiliations

    • Department of Psychiatry, Neuropsychology Section, University of Michigan School of Medicine, Ann Arbor, MA, USA
    • Department of Psychology, Suffolk University, Boston, MA, USA
  • ,
  • David A. Gansler

      Affiliations

    • Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA
    • Department of Psychology, Suffolk University, Boston, MA, USA
    • Lemuel Shattuck Hospital, Boston, MA, USA
    • Corresponding Author InformationCorresponding author. Department of Psychology, Suffolk University, 41 Temple Street, Boston, MA 02114, USA. Tel.: +1 617 305 6397; fax: +1 617 367 2924.
  • ,
  • Simon Tan

      Affiliations

    • Beth Israel Deaconess Medical Center, Behavioral Neurology Division, Boston, MA, USA
  • ,
  • Rafeeque Bhadelia

      Affiliations

    • Department of Radiology, Tufts University School of Medicine, Boston, MA, USA
  • ,
  • Sam Patz

      Affiliations

    • Department of Radiology, Tufts University School of Medicine, Boston, MA, USA
  • ,
  • Carl Fulwiler

      Affiliations

    • Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA
    • Lemuel Shattuck Hospital, Boston, MA, USA
    • Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA

Received 12 February 2004 ,Revised 25 February 2005 ,Accepted 12 May 2005.

References 

  1. Aron AR, Robbins TW, Poldrack RA. Inhibition and the right inferior frontal cortex. Trends in Cognitive Sciences. 2004;8(4):170–177
  2. Blair RJR. Neurocognitive models of aggression, the antisocial personality disorders, and psychopathy. Journal of Neurology, Neurosurgery and Psychiatry. 2001;71:727–731
  3. Blatter DD, Bigler ED, Gale SD, Johnson SC, Anderson CV, Burnett BM, et al. Quantitative volumetric analysis of brain MR: normative database spanning 5 decades of life. American Journal of Neuroradiology. 1995;16:241–251
  4. Brower MC, Price BH. Neuropsychiatry of frontal lobe dysfunction in violent and criminal behaviour: a critical review. Journal of Neurology, Neurosurgery and Psychiatry. 2001;71:720–726
  5. Buss AH, Perry M. The Aggression Questionnaire. Journal of Personality and Social Psychology. 1992;63(3):452–459
  6. Coccaro EF, Berman ME, Kavoussi RJ. Assessment of life history of aggression: development and psychometric characteristics. Psychiatry Research. 1997;73:147–157
  7. Crespo-Facorro B, Kim J, Andreasen NC, O'Leary DS, Wiser AK, Bailey JM, et al. Human frontal cortex: an MRI-based parcellation method. NeuroImage. 1999;10:500–519
  8. Davidson RJ, Putnam KM, Larson CL. Dysfunction in the neural circuitry of emotion regulation—a possible prelude to violence. Science. 2000;289:591–594
  9. Dougherty DD, Rauch SL, Deckersbach T, Marci C, Loh R, Shin LM, et al. Ventromedial prefrontal cortex and amygdala dysfunction during an anger induction positron emission tomography study in patients with major depressive disorder with anger attacks. Archives of General Psychiatry. 2004;61(8):795–804
  10. Duvernoy H. The Human Brain Surface, Blood Supply, and Three-dimensional Sectional Anatomy. Wien-New York: Springer-Verlag; 1991;
  11. Eichelman B, Hartwig A. Discussion: biological correlates of aggression. Annals of the New York Academy of Sciences. 1996;794:78–81
  12. Eronen M, Angermeyer MC, Schulze B. The psychiatric epidemiology of violent behaviour. Society of Psychiatry and Psychiatric Epidemiology. 1998;33:s13–s23
  13. Gatzke-Kopp LM, Raine A, Buchsbaum M, LaCasse L. Temporal lobe deficits in murderers: EEG findings undetected by PET. Journal of Neuropsychiatry and Clinical Neurosciences. 2001;13(4):486–491
  14. Giancola PR. Evidence for dorsolateral and orbital prefrontal cortical involvement in the expression of aggressive behavior. Aggressive Behavior. 1995;21:431–450
  15. Giancola PR, Zeichner A. Neuropsychological performance on tests of frontal-lobe functioning and aggressive behavior in men. Journal of Abnormal Psychology. 1994;103(4):832–835
  16. Goel V, Shuren J, Sheesley L, Grafman J. Asymmetrical involvement of frontal lobes in social reasoning. Brain. 2004;127:783–790
  17. Grafman J, Schwab K, Warden D, Pridgen A, Brown HR, Salazar AM. Frontal lobe injuries, violence, and aggression: a report of the Vietnam Head Injury Study. Neurology. 1996;46:1231–1238
  18. Kavoussi R, Armstead P, Coccaro E. The neurobiology of impulsive aggression. Psychiatric Clinics of North America. 1997;20(1):395–403
  19. Medx Users' Guide, 2002. Sensor Systems, Inc.; 2002;
  20. Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt Impulsiveness Scale. Journal of Clinical Psychology. 1995;51:768–774
  21. Pietrini P, Guazzelli M, Basso G, Jaffe K, Grafman J. Neural correlates of imaginal aggressive behavior assessed by positron emission tomography in healthy subjects. American Journal of Psychiatry. 2000;157(11):1772–1779
  22. Raine A, Buchsbaum M, LaCasse L. Brain abnormalities in murderers indicated by positron emission tomography. Biological Psychiatry. 1997;42:495–508
  23. Raine A, Lencz T, Bihrle S, LaCasse L, Colletti P. Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder. Archives of General Psychiatry. 2000;57:119–127
  24. Soderstrom H, Tullberg M, Wikkelso C, Ekholm S, Forsman A. Reduced regional cerebral blood flow in non-psychotic violent offenders. Psychiatry Research: Neuroimaging. 2000;98:29–41
  25. Soyka M. Substance misuse, psychiatric disorder and violent and disturbed behavior. British Journal of Psychiatry. 2000;176:345–350
  26. Tonkonogy J. Violence and temporal lobe lesion: head CT and MRI data. Journal of Neuropsychiatry. 1991;3(2):189–196
  27. Volavka J. The neurobiology of violence: an update. Journal of Neuropsychiatry and Clinical Neurosciences. 1999;11:307–314
  28. Winstanley CA, Theobald DEH, Cardinal RN, Robbins TW. Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice. Journal of Neuroscience. 2004;24(20):4718–4722

PII: S0925-4927(06)00046-1

doi: 10.1016/j.pscychresns.2005.05.016

Psychiatry Research: Neuroimaging
Volume 147, Issue 2 , Pages 213-220 , 30 October 2006