Psychiatry Research: Neuroimaging
Volume 148, Issue 1 , Pages 47-54 , 22 November 2006

Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects: A proton magnetic resonance spectroscopy study at 1.5 Tesla

  • Richard J. Maddock

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA, USA
    • Imaging Research Center, University of California Davis, Sacramento, CA, USA
    • Corresponding Author InformationCorresponding author. Imaging Research Center, UC Davis Medical Center, 4701 X Street, Sacramento, CA 95817, USA. Tel.: +1 916 734 3286; fax: +1 916 734 8750.
  • ,
  • Michael H. Buonocore

      Affiliations

    • Imaging Research Center, University of California Davis, Sacramento, CA, USA
    • Department of Radiology, University of California Davis, Sacramento, CA, USA
  • ,
  • Shawn P. Lavoie

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA, USA
    • Imaging Research Center, University of California Davis, Sacramento, CA, USA
  • ,
  • Linda E. Copeland

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA, USA
    • Imaging Research Center, University of California Davis, Sacramento, CA, USA
  • ,
  • Shawn J. Kile

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA, USA
    • Imaging Research Center, University of California Davis, Sacramento, CA, USA
  • ,
  • Anne L. Richards

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA, USA
    • Imaging Research Center, University of California Davis, Sacramento, CA, USA
  • ,
  • John M. Ryan

      Affiliations

    • Imaging Research Center, University of California Davis, Sacramento, CA, USA
    • Department of Radiology, University of California Davis, Sacramento, CA, USA

Received 30 November 2005 ,Revised 24 January 2006 ,Accepted 20 February 2006.

References 

  1. Abi-Saab WM, Maggs DG, Jones T, Jacob R, Srihari V, Thompson J, et al. Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemia. Journal of Cerebral Blood Flow and Metabolism. 2002;22:271–279
  2. Auer DP, Gossl C, Schirmer T, Czisch M. Improved analysis of 1H-MR spectra in the presence of mobile lipids. Magnetic Resonance in Medicine. 2001;46:615–618
  3. Baynes, J., Dominiczak, M., 2005. Medical Biochemistry. Elsevier Mosby, Philadelphia.
  4. Boucard CC, Mostert JP, Cornelissen FW, DeKeyser J, Oudkerk M, Sijens PE. Visual stimulation, 1H MR spectroscopy and FMRI of the human visual pathways. European Radiology. 2005;15:47–52
  5. Brautbar N, Leibovici H, Massry SG. On the mechanism of hypophosphatemia during acute hyperventilation: evidence for increased muscle glycolysis. Mineral and Electrolyte Metabolism. 1983;9:45–50
  6. Brooks GA. Lactate production under fully aerobic conditions: the lactate shuttle during rest and exercise. Federation Proceedings. 1986;45:2924–2929
  7. Chesler M. Regulation and modulation of pH in the brain. Physiological Reviews. 2003;83:1183–1221
  8. Dager SR, Strauss WL, Marro KI, Richards TL, Metzger GD, Artru AA. Proton magnetic resonance spectroscopy investigation of hyperventilation in subjects with panic disorder and comparison subjects. American Journal of Psychiatry. 1995;152:666–672
  9. Dager SR, Friedman SD, Heide A, Layton ME, Richards T, Artru A, et al. Two-dimensional proton echo-planar spectroscopic imaging of brain metabolic changes during lactate-induced panic. Archives of General Psychiatry. 1999;56:70–77
  10. Ernst T, Chang L. Elimination of artifacts in short echo time 1H MR spectroscopy of the frontal lobe. Magnetic Resonance in Medicine. 1996;36:462–468
  11. Frahm J, Kruger G, Merboldt KD, Kleinschmidt A. Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man. Magnetic Resonance in Medicine. 1996;35:143–148
  12. Gladden LB. Lactate metabolism: a new paradigm for the third millennium. Journal of Physiology. 2004;558:5–30
  13. Hood VL, Tannen RL. Protection of acid–base balance by pH regulation of acid production. New England Journal of Medicine. 1998;339:819–826
  14. Hu Y, Wilson GS. A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor. Journal of Neurochemistry. 1997;69:1484–1490
  15. Itoh Y, Law MJ, Sokoloff L. Effects of the Na(+)/H(+) exchanger monensin on intracellular pH in astroglia. Brain Research. 2000;882:226–229
  16. Kruger G, Kastrup A, Takahashi A, Glover G. Simultaneous monitoring of dynamic changes in cerebral blood flow and oxygenation during sustained activation of the human visual cortex. NeuroReport. 1999;10:2939–2943
  17. Kuwabara T, Watanabe H, Tanaka K, Tsuji S, Ohkubo M, Ito T, et al. Mitochondrial encephalomyopathy: elevated visual cortex lactate unresponsive to photic stimulation—a localized 1H-MRS study. Neurology. 1994;44:557–559
  18. Lundbom NM, Manner T, Komu M, Peltola O, Leino KA, Kirvela OA. Barbiturate anesthesia and brain proton spectroscopy. AJNR American Journal of Neuroradiology. 1999;20:1543–1546
  19. Maddock RJ. The lactic acid response to alkalosis in panic disorder: an integrative review. Journal of Neuropsychiatry and Clinical Neurosciences. 2001;13:22–34
  20. Maddock RJ, Buonocore MH. Elevated lactate response during neural activation in panic disorder. In: Presented at the International Society for Magnetic Resonance in Medicine Workshop on MR Spectroscopy in Neuropsychiatric Disorders (October 2005). Banff, Alberta, Canada: ISMRM; 2005;
  21. Maddock RJ, Mateo-Bermudez J. Elevated serum lactate following hyperventilation during glucose infusion in panic disorder. Biological Psychiatry. 1990;27:411–418
  22. Mangia S, Garreffa G, Bianciardi M, Giove F, DiSalle F, Maraviglia B. The aerobic brain: lactate decrease at the onset of neural activity. Neuroscience. 2003;118:7–10
  23. Merboldt KD, Bruhn H, Hanicke W, Michaelis T, Frahm J. Decrease of glucose in the human visual cortex during photic stimulation. Magnetic Resonance in Medicine. 1992;25:187–194
  24. MRUI, 2003. Magnetic resonance user interface, vol. 2003. Available at http://carbon.uab.es/mrui/mrui_Overview.shtml.
  25. Pellerin L, Pellegri G, Bittar PG, Charnay Y, Bouras C, Martin JL, et al. Evidence supporting the existence of an activity dependent astrocyte-neuron lactate shuttle. Developmental Neuroscience. 1998;20:291–299
  26. Prichard J, Rothman D, Novotny E, Petroff O, Kuwabara T, Avison M, et al. Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation. Proceedings of the National Academy of Sciences of the United States of America. 1991;88:5829–5831
  27. Richards TL, Gates GA, Gardner JC, Merrill T, Hayes CE, Panagiotides H, et al. Functional MR spectroscopy of the auditory cortex in healthy subjects and patients with sudden hearing loss. American Journal of Neuroradiology. 1997;18:611–620
  28. Richards T, Dager SR, Corina D, Serafini S, Heide AC, Steury K, et al. Dyslexic children have abnormal brain lactate response to reading-related language tasks. American Journal of Neuroradiology. 1999;20:1393–1398
  29. Richards TL, Corina D, Serafini S, Steury K, Echelard DR, Dager SR, et al. Effects of a phonologically driven treatment for dyslexia on lactate levels measured by proton MR spectroscopic imaging. American Journal of Neuroradiology. 2000;21:916–922
  30. Sandor PS, Dydak U, Schoenen J, Kollias SS, Hess K, Boesiger P, et al. MR-spectroscopic imaging during visual stimulation in subgroups of migraine with aura. Cephalalgia. 2005;25:507–518
  31. Sappey-Marinier D, Calabrese G, Fein G, Hugg JW, Biggins C, Weiner MW. Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy. Journal of Cerebral Blood Flow and Metabolism. 1992;12:584–592
  32. Schurr A. Lactate: the ultimate cerebral oxidative energy substrate?. Journal of Cerebral Blood Flow and Metabolism. 2005;
  33. Trivedi B, Danforth WH. Effect of pH on the kinetics of frog muscle phosphofructokinase. Journal of Biological Chemistry. 1966;241:4110–4114
  34. Urrila AS, Hakkarainen A, Heikkinen S, Vuori K, Stenberg D, Hakkinen AM, et al. Stimulus-induced brain lactate: effects of aging and prolonged wakefulness. Journal of Sleep Research. 2004;13:111–119

PII: S0925-4927(06)00045-X

doi: 10.1016/j.pscychresns.2006.02.004

Psychiatry Research: Neuroimaging
Volume 148, Issue 1 , Pages 47-54 , 22 November 2006