Psychiatry Research: Neuroimaging
Volume 147, Issue 2 , Pages 135-143 , 30 October 2006

Regional cerebral blood flow changes in depression after electroconvulsive therapy

  • Kazuhisa Segawa

      Affiliations

    • Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
    • ,
  • Hideki Azuma

      Affiliations

    • Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
    • ,
  • Kiyoe Sato

      Affiliations

    • Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
    • ,
  • Toshinobu Yasuda

      Affiliations

    • Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
    • ,
  • Keiko Arahata

      Affiliations

    • Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
    • ,
  • Kazuyuki Otsuki

      Affiliations

    • Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
    • ,
  • Junko Tohyama

      Affiliations

    • Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    • ,
  • Tsutomu Soma

      Affiliations

    • Clinical Application Technology Group, Daiichi Radioisotope Laboratories, Ltd., Tokyo, Japan
    • Osaka University, Medical Department, School of Allied Health Sciences, Health Medical Engineering, Osaka, Japan
    • ,
  • Tetsuya Iidaka

      Affiliations

    • Department of Psychology, Nagoya University Graduate School of Environmental Studies, Nagoya, Japan
    • ,
  • Shutaro Nakaaki

      Affiliations

    • Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
    • ,
  • Toshi A. Furukawa

      Affiliations

    • Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 52 853 8271; fax: +81 52 852 0837.

Received 4 March 2004 ,Revised 19 July 2004 ,Accepted 1 August 2004.

References 

  1. Abou-Saleh MT, Al Suhaili AR, Karim L, Prais V, Hamdi E. Single photon emission tomography with 99mTc-HMPAO in Arab patients with depression. Journal of Affective Disorders. 1999;55:115–123
  2. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 4th edn.. Washington, DC: American Psychiatric Press; 1994;
  3. Austin MP, Dougall N, Ross M, Murray C, O'Carroll RE, Moffoot A, et al. Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum. Journal of Affective Disorders. 1992;26:31–43
  4. Awata S, Konno M, Kawashima R, Suzuki K, Sato T, Matsuoka H, et al. Changes in regional cerebral blood flow abnormalities in late-life depression following response to electroconvulsive therapy. Psychiatry and Clinical Neurosciences. 2002;56:31–40
  5. Bench CJ, Friston KJ, Brown RG, Frackowiak RS, Dolan RJ. Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions. Psychological Medicine. 1993;23:579–590
  6. Bench CJ, Frackowiak RS, Dolan RJ. Changes in regional cerebral blood flow on recovery from depression. Psychological Medicine. 1995;25:247–261
  7. Blumenfeld H, McNally KA, Ostroff RB, Zubal IG. Targeted prefrontal cortical activation with bifrontal ECT. Psychiatry Research: Neuroimaging. 2003;123:165–170
  8. Bonne O, Krausz Y, Shapira B, Bocher M, Karger H, Gorfine M, et al. Increased cerebral blood flow in depressed patients responding to electroconvulsive therapy. Journal of Nuclear Medicine. 1996;37:1075–1080
  9. Bonne O, Louzoun Y, Aharon I, Krausz Y, Karger H, Lerer B, et al. Cerebral blood flow in depressed patients: a methodological comparison of statistical parametric mapping and region of interest analyses. Psychiatry Research: Neuroimaging. 2003;122:49–57
  10. Brody AL, Saxena S, Stoessel P, Gillies LA, Fairbanks LA, Alborzian S, et al. Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings. Archives of General Psychiatry. 2001;58:631–640
  11. Chang LT. A method for attenuation correction in radionuclide computed tomography. IEEE Transaction on Nuclear Science. 1978;25:638–643
  12. Drevets WC. Neuroimaging studies of mood disorders. Biological Psychiatry. 2000;48:813–829
  13. Drevets WC, Videen TO, Price JL, Preskorn SH, Carmichael ST, Raichle ME. A functional anatomical study of unipolar depression. Journal of Neuroscience. 1992;12:3628–3641
  14. Elizagarate E, Cortes J, Gonzalez Pinto A, Gutierrez M, Alonso I, Alcorta P, et al. Study of the influence of electroconvulsive therapy on the regional cerebral blood flow by HMPAO–SPECT. Journal of Affective Disorders. 2001;65:55–59
  15. Friston KJ, Holmes AP, Worsley KJ, Poline JP, Frith CD, Frackowiak RSJ. Statistical parametric maps in functional imaging: a general linear approach. Human Brain Mapping. 1995;2:189–210
  16. Frodl T, Meisenzahl E, Zetzsche T, Bottlender R, Born C, Groll C, et al. Enlargement of the amygdala in patients with a first episode of major depression. Biological Psychiatry. 2002;51:708–714
  17. Frodl T, Meisenzahl EM, Zetzsche T, Born C, Jager M, Groll C, et al. Larger amygdala volumes in first depressive episode as compared to recurrent major depression and healthy control subjects. Biological Psychiatry. 2003;53:338–344
  18. Goldapple K, Segal Z, Garson C, Lau M, Bieling P, Kennedy S, et al. Modulation of cortical–limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy. Archives of General Psychiatry. 2004;61:34–41
  19. Henry ME, Schmidt ME, Matochik JA, Stoddard EP, Potter WZ. The effects of ECT on brain glucose: a pilot FDG PET study. Journal of ECT. 2001;17:33–40
  20. Hornig M, Mozley PD, Amsterdam JD. HMPAO SPECT brain imaging in treatment-resistant depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1997;21:1097–1114
  21. Jensen J, McIntosh AR, Crawley AP, Mikulis DJ, Remington G, Kapur S. Direct activation of the ventral striatum in anticipation of aversive stimuli. Neuron. 2003;40:1251–1257
  22. Kaisti KK, Langsjo JW, Aalto S, Oikonen V, Sipila H, Teras M, et al. Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiology. 2003;99:603–613
  23. Kennedy SH, Evans KR, Kruger S, Mayberg HS, Meyer JH, McCann S, et al. Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression. American Journal of Psychiatry. 2001;158:899–905
  24. Liotti M, Mayberg HS, McGinnis S, Brannan SL, Jerabek P. Unmasking disease-specific cerebral blood flow abnormalities: mood challenge in patients with remitted unipolar depression. American Journal of Psychiatry. 2002;159:1830–1840
  25. MacHale SM, Lawrie SM, Cavanagh JT, Glabus MF, Murray CL, Goodwin GM, et al. Cerebral perfusion in chronic fatigue syndrome and depression. British Journal of Psychiatry. 2000;176:550–556
  26. Maes M, Dierckx R, Meltzer HY, Ingels M, Schotte C, Vandewoude M, et al. Regional cerebral blood flow in unipolar depression measured with Tc-99m-HMPAO single photon emission computed tomography: negative findings. Psychiatry Research: Neuroimaging. 1993;50:77–88
  27. Martinot JL, Hardy P, Feline A, Huret JD, Mazoyer B, Attar-Levy D, et al. Left prefrontal glucose hypometabolism in the depressed state: a confirmation. American Journal of Psychiatry. 1990;147:1313–1317
  28. Mayberg HS. Modulating dysfunctional limbic–cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. British Medical Bulletin. 2003;65:193–207
  29. Mayberg HS, Lewis PJ, Regenold W, Wagner HN. Paralimbic hypoperfusion in unipolar depression. Journal of Nuclear Medicine. 1994;35:929–934
  30. Mayberg HS, Brannan SK, Mahurin RK, McGinnis S, Jerabek PA. Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biological Psychiatry. 2000;48:830–843
  31. Mervaala E, Kononen M, Fohr J, Husso-Saastamoinen M, Valkonen-Korhonen M, Kuikka JT, et al. SPECT and neuropsychological performance in severe depression treated with ECT. Journal of Affective Disorders. 2001;66:47–58
  32. Milo TJ, Kaufman GE, Barnes WE, Konopka LM, Crayton JW, Ringelstein JG, et al. Changes in regional cerebral blood flow after electroconvulsive therapy for depression. Journal of ECT. 2001;17:15–21
  33. Nobler MS, Sackeim HA. Mechanisms of action of electroconvulsive therapy: functional brain imaging studies. Psychiatric Annals. 1998;28:23
  34. Nobler MS, Sackeim HA, Prohovnik I, Moeller JR, Mukherjee S, Schnur DB, et al. Regional cerebral blood flow in mood disorders: III. Treatment and clinical response. Archives of General Psychiatry. 1994;51:884–897
  35. Nobler MS, Oquendo MA, Kegeles LS, Malone KM, Campbell CC, Sackeim HA, et al. Decreased regional brain metabolism after ECT. American Journal of Psychiatry. 2001;158:305–308
  36. Ohnishi T, Matsuda H, Hashimoto T, Kunihiro T, Nishikawa M, Uema T, et al. Abnormal regional cerebral blood flow in childhood autism. Brain. 2000;123(Pt 9):1838–1844
  37. Oshima t, Karasawa F, Okazaki Y, Wada H, Satoh T. Effects of sevoflurane on cerebral blood flow and cerebral metabolic rate of oxygen in human beings: a comparison with isoflurane. European Journal of Anaesthesiology. 2003;20:543–547
  38. Scott AI, Dougall N, Ross M, O'Carroll RE, Riddle W, Ebmeier KP, et al. Short-term effects of electroconvulsive treatment on the uptake of 99mTc-exametazime into brain in major depression shown with single photon emission tomography. Journal of Affective Disorders. 1994;30:27–34
  39. Sheline YI. Neuroimaging studies of mood disorder effects on the brain. Biological Psychiatry. 2003;54:338–352
  40. Siegle GJ, Steinhauer SR, Thase ME, Stenger VA, Carter CS. Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biological Psychiatry. 2002;51:693–707
  41. Silfverskiold P, Gustafson L, Risberg J, Rosen I. Acute and late effects of electroconvulsive therapy. Clinical outcome, regional cerebral blood flow, and electroencephalogram. Annals of the New York Academy of Sciences. 1986;462:236–248
  42. Talairach J, Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain. Germany: Georg Thieme Verlag: Stuttgart; 1988;
  43. Tremblay LK, Naranjo CA, Cardenas L, Herrmann N, Busto UE. Probing brain reward system function in major depressive disorder: altered response to dextroamphetamine. Archives of General Psychiatry. 2002;59:409–416
  44. Tutus A, Simsek A, Sofuoglu S, Nardali M, Kugu N, Karaaslan F, et al. Changes in regional cerebral blood flow demonstrated by single photon emission computed tomography in depressive disorders: comparison of unipolar vs. bipolar subtypes. Psychiatry Research: Neuroimaging. 1998;83:169–177
  45. UK ECT Review Group . Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet. 2003;361:799–808
  46. Vangu MD, Esser JD, Boyd IH, Berk M. Effects of electroconvulsive therapy on regional cerebral blood flow measured by 99mtechnetium HMPAO SPECT. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2003;27:15–19
  47. Videbech P, Ravnkilde B, Pedersen AR, Egander A, Landbo B, Rasmussen NA, et al. The Danish PET/Depression Project: PET findings in patients with major depression. Psychological Medicine. 2001;31:1147–1158
  48. Williams JB. A structured interview guide for the Hamilton depression scale. Archives of General Psychiatry. 1988;45:742–747
  49. Yatham LN, Clark CC, Zis AP. A preliminary study of the effects of electroconvulsive therapy on regional brain glucose metabolism in patients with major depression. Journal of ECT. 2000;16:171–176

PII: S0925-4927(06)00023-0

doi: 10.1016/j.pscychresns.2004.08.006

Psychiatry Research: Neuroimaging
Volume 147, Issue 2 , Pages 135-143 , 30 October 2006

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